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1.
公开(公告)号:US07265116B2
公开(公告)日:2007-09-04
申请号:US10917801
申请日:2004-08-13
申请人: James P. Beck , Matt A. Curry , Mark A. Smith
发明人: James P. Beck , Matt A. Curry , Mark A. Smith
IPC分类号: A61K31/50
CPC分类号: C07D401/04 , C07D217/04 , C07D405/04 , C07D409/04 , C07D413/04
摘要: Provided herein are compounds of the formula (I): wherein R1-R8 are as described herein, R4 being phthalazinyl, pyrazinyl, pyridazinyl, or quinoxalinyl. Such compounds are particularly useful in the treatment of a disorder which is created by or is dependent upon decreased availability of serotonin, norepinephrine, or dopamine.
摘要翻译: 本文提供了式(I)的化合物:其中R 1 -R 8如本文所述,R 4是酞嗪基,吡嗪基, 哒嗪基或喹喔啉基。 这样的化合物特别可用于治疗由5-羟色胺,去甲肾上腺素或多巴胺的可用性降低而产生或依赖于其的依赖性。
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2.
公开(公告)号:US06579885B2
公开(公告)日:2003-06-17
申请号:US10091949
申请日:2002-03-06
申请人: James P. Beck , Matt A. Curry , Mark A. Smith
发明人: James P. Beck , Matt A. Curry , Mark A. Smith
IPC分类号: C07D21702
CPC分类号: C07D401/04 , C07D217/04 , C07D405/04 , C07D409/04 , C07D413/04
摘要: Provided herein are compounds of the formula (I): wherein R1-R8 are as described herein, R4 being aryl or heteroaryl Such compounds are particularly useful in the treatment of a disorder which is created by or is dependent upon decreased availability of serotonin, norepinephrine or dopamine.
摘要翻译: 本文提供了式(I)的化合物:其中R 1 -R 8如本文所述,R 4是芳基或杂芳基。该化合物特别可用于治疗由5-羟色胺,去甲肾上腺素的可用性降低而产生或依赖于 或多巴胺。
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公开(公告)号:US07612090B2
公开(公告)日:2009-11-03
申请号:US10426097
申请日:2003-04-29
申请人: James P. Beck , Matt A. Curry , Mark A. Smith
发明人: James P. Beck , Matt A. Curry , Mark A. Smith
IPC分类号: C07D217/00 , A61K31/47
CPC分类号: C07D401/04 , C07D217/04 , C07D405/04 , C07D409/04 , C07D413/04
摘要: Provided herein are compounds of the formula (I): wherein R1-R8 are as described herein, R4 being aryl or heteroaryl Such compounds are particularly useful in the treatment of a disorder which is created by or is dependent upon decreased availability of serotonin, norepinephrine or dopamine.
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公开(公告)号:US07163949B1
公开(公告)日:2007-01-16
申请号:US09704306
申请日:2000-11-02
申请人: James P. Beck , Mark A. Smith
发明人: James P. Beck , Mark A. Smith
IPC分类号: A61P25/00 , A61K31/535 , A61K31/47 , C07D413/00 , C07D217/00
CPC分类号: C07D217/14 , C07D217/16 , C07D217/24
摘要: Provided herein are compounds of the formulae IA–IF. These compounds are tetrahydroisoquinolines of the following structure: wherein R1–R8 for compounds of each of the formulae IA, IB, IC, ID, IE and IF are as described herein. Said compounds are particularly useful in the treatment of various neurological and psychiatric disorders, e.g., ADHD.
摘要翻译: 本文提供式IA-IF的化合物。 这些化合物是以下结构的四氢异喹啉:式IA,IB,IC,ID,IE和IF各自化合物的R 1〜R 8如上所述 这里。 所述化合物特别可用于治疗各种神经和精神疾病,例如ADHD。
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公开(公告)号:USPP29152P2
公开(公告)日:2018-03-27
申请号:US15530073
申请日:2016-11-30
IPC分类号: A01H5/02
CPC分类号: A01H5/02 , A01H6/1424
摘要: A new and distinct cultivar of Dendranthema plant named ‘Harvest Igloo’, characterized by its upright, outwardly spreading and uniformly mounded plant habit; freely branching habit; dense and full plant form; uniform and freely flowering habit; decorative-type inflorescences; bronze-colored ray florets; natural season flowering occurs about September 13 to 18 in Pennsylvania; and good garden performance and winter hardiness.
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公开(公告)号:US08757441B2
公开(公告)日:2014-06-24
申请号:US13645315
申请日:2012-10-04
申请人: Mark A. Smith , Carsten Pfromm
发明人: Mark A. Smith , Carsten Pfromm
IPC分类号: B65D35/56
CPC分类号: B67D3/0067 , B67D3/0054 , B67D3/0061 , B67D3/041 , B67D2210/00049 , F16K7/06
摘要: The present invention provides a container assembly for use with a reusable urn or vessel. The assembly includes a (1) flexible pouch, (2) a fitment connected to the pouch and having a flexible flange and a first fluid passageway therethrough in fluid communication with the chamber, (3) a tubing adapter having a first end connected to the fitment and a second end having a member for connecting to a tubing and a second fluid passageway in fluid communication with the first fluid passageway; and (4) wherein the flexible flange is capable of bending to conform to an interior wall of the urn or vessel to place the second fluid passageway in alignment with an axis of a through hole in the urn or vessel.
摘要翻译: 本发明提供一种与可重复使用的瓮或容器一起使用的容器组件。 组件包括(1)柔性袋,(2)连接到袋并具有柔性凸缘和通过其与腔室流体连通的第一流体通道的配件,(3)管接头,其具有连接到 配件和具有用于连接到管道的构件和与第一流体通道流体连通的第二流体通道的第二端; 和(4)其中柔性凸缘能够弯曲以符合瓮或容器的内壁,以将第二流体通道与瓮或容器中的通孔的轴线对准。
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公开(公告)号:USPP24025P2
公开(公告)日:2013-11-12
申请号:US13385260
申请日:2012-02-10
申请人: Mark A. Smith
发明人: Mark A. Smith
IPC分类号: A01H5/00
CPC分类号: A01H6/1424 , A01H5/02
摘要: A new Chrysanthemum plant named ‘CIFZ0021’ particularly distinguished by the small red-purple decorative inflorescences with medium green foliage, compact and mounded plant habit with a mid to late September natural flowering season.
摘要翻译: 一个名为“CIFZ0021”的新菊花植物,特别以中等绿色叶子的小红紫色装饰花序,9月中旬至9月中旬自然开花的季节,紧凑而夯实的植物习性。
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公开(公告)号:US08556399B2
公开(公告)日:2013-10-15
申请号:US13126899
申请日:2008-10-30
申请人: Marjan S. Amesbury , Mark A. Smith
发明人: Marjan S. Amesbury , Mark A. Smith
IPC分类号: B41J2/175
CPC分类号: B41J2/1752 , B41J2/17513 , B41J2/17563
摘要: A fluid interconnect for a fluid ejection system includes a fluid port having a fluid passage formed therethrough, and a filter provided at an end of the fluid port such that fluid passing through the fluid port passes through the filter to the fluid passage, wherein the filter is secured to an end surface and a peripheral surface of the fluid port.
摘要翻译: 用于流体喷射系统的流体互连件包括具有通过其形成的流体通道的流体端口和设置在流体端口的端部处的过滤器,使得流过流体端口的流体通过过滤器到达流体通道,其中过滤器 被固定到流体端口的端面和外周表面。
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公开(公告)号:USPP23909P2
公开(公告)日:2013-09-17
申请号:US13385183
申请日:2012-02-06
申请人: Mark A. Smith
发明人: Mark A. Smith
IPC分类号: A01H5/00
CPC分类号: A01H6/1424 , A01H5/02
摘要: A new Chrysanthemum plant named ‘CIFZ0019’ particularly distinguished by the small light red to orange-red over yellow decorative inflorescences with medium yellow-green foliage, compact and mounded plant habit with a mid to late September natural flowering season.
摘要翻译: 一个名为“CIFZ0019”的新菊花植物,特别区别于中等黄绿色叶子,9月中旬至9月中旬自然开花季节的黄绿色装饰花序中的小红色至橙红色。
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公开(公告)号:USPP23908P2
公开(公告)日:2013-09-17
申请号:US13385223
申请日:2012-02-08
申请人: Mark A. Smith
发明人: Mark A. Smith
IPC分类号: A01H5/00
CPC分类号: A01H6/1424 , A01H5/02
摘要: A new Chrysanthemum plant named ‘CIFZ0024’ particularly distinguished by the small to medium sized decorative inflorescences, darker yellow-green foliage, medium ball-shaped plant habit, with a natural flowering season response of mid-September.
摘要翻译: 一个名为“CIFZ0024”的新菊花植物,特别是中小尺寸装饰花序,深黄绿色叶子,中等球形植物习性,9月中旬开花季节响应。
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