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公开(公告)号：US20050208542A1
公开(公告)日：2005-09-22
申请号：US11031531
申请日：2005-01-07
申请人： James Rusling , John Schenkman , Liping Zhou , Jing Yang
发明人： James Rusling , John Schenkman , Liping Zhou , Jing Yang
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/543
CPC分类号： C12Q1/6825 , G01N33/5308 , G01N33/5438
摘要： A biosensor is described comprising an electrode, a protein layer (s), and a double-stranded polynucleotide layer (s). Also included do arrays, kits, and instruments comprise the biosensors. The biosensors may be used to detect double-stranded polynucleotide damage resulting from metabolism of a test compound, such as a drug candidate, by the protein in the protein layer.
摘要翻译： 描述了包括电极，蛋白质层和双链多核苷酸层的生物传感器。 阵列，套件和仪器也包括生物传感器。 生物传感器可以用于检测由蛋白质层中的蛋白质测试化合物（例如候选药物）的代谢产生的双链多核苷酸损伤。
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2.发明申请公开(公告)号：US20060240492A1
公开(公告)日：2006-10-26
申请号：US11272467
申请日：2005-11-11
IPC分类号： G01N33/574
CPC分类号： G01N33/551
摘要： An immunoassay device comprises a plurality of carbon nanotubes having a first end and a second end, wherein the nanotubes are aligned substantially parallel relative to one another; a substrate responsive to an electrochemical signal, the substrate being attached to the first end of at least a portion of the plurality of nanotubes; and a capture antibody attached to at least a portion of the nanotubes not at the first end. An immunoassay method comprises providing the disclosed immunoassay device, contacting the immunoassay with a test sample under conditions suitable for binding of an analyte to the capture antibody, wherein binding of the analyte generates, directly or indirectly, an electrochemical signal and detecting the signal. Methods of making the disclosed immunoassay device are also disclosed.
摘要翻译： 免疫测定装置包括具有第一端和第二端的多个碳纳米管，其中所述纳米管相对于彼此基本平行排列; 响应于电化学信号的衬底，所述衬底附接到所述多个纳米管的至少一部分的第一端; 以及不在第一端附着于纳米管的至少一部分的捕获抗体。 免疫测定方法包括提供所公开的免疫测定装置，在适于将分析物与捕获抗体结合的条件下，将免疫测定与测试样品接触，其中分析物的结合直接或间接产生电化学信号并检测信号。 还公开了制备所公开的免疫测定装置的方法。
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