公开(公告)号：US06337339B2

公开(公告)日：2002-01-08

申请号：US09794006

申请日：2001-02-28

申请人： James W. Young ,  A. K. Gunnar Aberg

发明人： James W. Young ,  A. K. Gunnar Aberg

IPC分类号： A61K3147

CPC分类号： A61K31/47 ,  A61K31/496 ,  Y02A50/475 ,  Y02A50/481

摘要： Methods and compositions are disclosed utilizing the optically pure (S)-isomer of lomefloxacin to treat bacterial infection. In particular, this compound is a potent drug for the treatment of Mycobacteria infection.

摘要翻译： 公开了使用洛美沙星的光学纯（S） - 异构体来治疗细菌感染的方法和组合物。 特别地，该化合物是用于治疗分枝杆菌感染的有效药物。

公开(公告)号：US6083993A

公开(公告)日：2000-07-04

申请号：US466107

申请日：1999-12-17

申请人： Timothy J. Barberich ,  James W. Young

发明人： Timothy J. Barberich ,  James W. Young

IPC分类号： A61K31/135 ,  A61K31/165 ,  A61K31/19 ,  A61K31/60 ,  A61K31/616 ,  A61P11/00 ,  A61P11/08

CPC分类号： A61K31/135

摘要： The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with albuterol.

摘要翻译： 基本上不含S（+）异构体的沙丁胺醇的光学纯的R（ - ）异构体是一种有效的支气管扩张剂，用于缓解个体与哮喘相关的症状。 公开了利用沙丁胺醇的光学纯的R（ - ）异构体治疗哮喘，同时最小化与沙丁胺醇相关的副作用的方法。

公开(公告)号：US5955477A

公开(公告)日：1999-09-21

申请号：US752984

申请日：1996-11-21

申请人： Nancy M. Gray ,  James W. Young

发明人： Nancy M. Gray ,  James W. Young

IPC分类号： C07D211/62 ,  A61K31/445 ,  A61K31/4468 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P1/14

CPC分类号： A61K31/445 ,  A61K31/4468

摘要： The optically pure (-) isomer of cisapride is useful for the treatment of dyspepsia and such other conditions as may be related to the activity of (-) cisapride as a prokinetic agent, such as gastroparesis, constipation, post-operative ileus, and intestinal pseudo-obstruction, without the concomitant liability of adverse effects associated with the racemic mixture of cisapride. The (-) isomer of cisapride also exhibits longer duration of action than does racemic cisapride and is useful for treatment of disorders of the central nervous system.

摘要翻译： 西沙必利的光学纯（ - ）异构体可用于治疗消化不良和其他可能与（ - ）西沙必利作为促动力剂如胃轻瘫，便秘，手术后肠梗阻和肠道活动有关的其他病症 假性梗阻，没有与西沙必利的外消旋混合物有关的副作用的伴随的责任。 西沙必利的（ - ）异构体也表现出比外消旋西沙必利更长的作用时间，并且可用于治疗中枢神经系统疾病。

公开(公告)号：US5708035A

公开(公告)日：1998-01-13

申请号：US446348

申请日：1995-05-22

申请人： James W. Young ,  Timothy J. Barberich ,  Martin H. Teicher

发明人： James W. Young ,  Timothy J. Barberich ,  Martin H. Teicher

IPC分类号： A61K31/138 ,  A61K31/35

CPC分类号： A61K31/138

摘要： A method and composition are disclosed utilizing the pure R(-) isomer of fluoxetine which is a potent antidepressant and appetite suppressant substantially free of adverse effects. In addition, a method and composition are disclosed utilizing the pure R(-) isomer of fluoxetine which is useful to treat migraine headaches, pain, in particular chronic pain, psychoactive substance abuse disorders and obsessive compulsive disorders.

摘要翻译： 公开了使用氟西汀的纯R（ - ）异构体的方法和组合物，其是有效的抗抑郁药和食欲抑制剂，其基本上没有不利影响。 另外，公开了使用氟西汀的纯R（ - ）异构体的方法和组合物，其可用于治疗偏头痛，疼痛，特别是慢性疼痛，精神活性物质滥用障碍和强迫症。

公开(公告)号：US5629329A

公开(公告)日：1997-05-13

申请号：US690242

申请日：1996-07-19

申请人： Nancy M. Gray ,  James W. Young

发明人： Nancy M. Gray ,  James W. Young

IPC分类号： C07D211/62 ,  A61K31/445 ,  A61K31/4468 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P1/14 ,  A61K31/395 ,  C07D409/06

CPC分类号： A61K31/445 ,  A61K31/4468

摘要： Methods are disclosed utilizing the optically pure (+) isomer of cisapride. This compound is a potent drug for the treatment of gastro-esophageal reflux disease while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of cisapride. This compound is also useful in treating or preventing emesis while substantially reducing adverse effects associated with racemic cisapride. The optically pure (+) isomer of cisapride is also useful for the treatment of dyspepsia and such other conditions as may be related to the activity of (+) cisapride as a prokinetic agent, such as gastroparesis, constipation, post-operative ileus, and intestinal pseudo-obstruction, without the concomitant liability of adverse effects associated with the racemic mixture of cisapride. The (+) isomer of cisapride also exhibits longer duration of action than does racemic cisapride and is useful for treatment of disorders of the central nervous system.

摘要翻译： 公开利用西沙必利的光学纯（+）异构体的方法。 该化合物是用于治疗胃食管反流疾病的有效药物，同时显着减少与西沙必利的外消旋混合物相关的副作用的伴随的责任。 该化合物也可用于治疗或预防呕吐，同时显着降低与西西沙必利素有关的不良反应。 西沙必利的光学纯的（+）异构体也可用于治疗消化不良和其它可能与（+）西沙必利作为促动力剂的活性相关的其它病症，例如胃轻瘫，便秘，手术后肠梗阻和 肠假性梗阻，没有与西沙必利的外消旋混合物相关的副作用的伴随的责任。 西沙必利的（+）异构体也表现出比外消旋西沙必利更长的作用时间，并且可用于治疗中枢神经系统疾病。

公开(公告)号：US5547994A

公开(公告)日：1996-08-20

申请号：US335480

申请日：1994-11-07

申请人： Timothy J. Barberich ,  James W. Young

发明人： Timothy J. Barberich ,  James W. Young

IPC分类号： A61K31/135 ,  A61K31/137

CPC分类号： A61K31/137 ,  A61K31/135 ,  Y10S514/826

摘要： The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with albuterol.

摘要翻译： 基本上不含S（+）异构体的沙丁胺醇的光学纯的R（ - ）异构体是一种有效的支气管扩张剂，用于缓解个体与哮喘相关的症状。 公开了利用沙丁胺醇的光学纯的R（ - ）异构体治疗哮喘，同时最小化与沙丁胺醇相关的副作用的方法。

公开(公告)号：US4262759A

公开(公告)日：1981-04-21

申请号：US78366

申请日：1979-09-24

申请人： James W. Young ,  Ricky K. Schpok

发明人： James W. Young ,  Ricky K. Schpok

IPC分类号： E21B10/22 ,  E21B10/25 ,  E21B10/30 ,  F16J15/16 ,  F16J15/32 ,  E21B10/24

CPC分类号： E21B10/25 ,  E21B10/30 ,  F16J15/164 ,  F16J15/3208

摘要： A drill string reamer-stabilizer includes a main body adapted to be connected as an element of a rotary drill string. Individual bearing shafts are mounted axially along the exterior of the main body supporting roller cutters that engage the wall of the borehole. Seal units are positioned around each bearing shaft between each roller cutter and bearing shaft to define a lubricant space. The seal units retain lubricant in the lubricant space and prevent contaminating fluid and materials in the borehole from entering the lubricant space. At least one seal unit comprises an annular cup-shaped elastomer seal member with an annular lip mounted in an annular seal gland in the roller cutter. The seal gland has an inner side adjacent the lubricant space and an outer side exposed to the fluid and materials in the borehole. A ring of compressible filler material fits in the cavity of the cup-shaped elastomer seal member and allows the elastomer seal member to deform so that internal pressure in the lubricant space is vented outward past the annular lip of the seal member but allows external pressure of fluid and materials in the borehole to force the seal member against the inner side of the seal gland creating a fluid tight seal.

摘要翻译： 钻杆铰刀稳定器包括适于作为旋转钻柱的元件连接的主体。 单独的轴承轴沿着与钻孔的壁接合的主体支撑辊切割器的外部轴向安装。 密封单元围绕每个滚子切割器和轴承轴之间的每个轴承轴定位，以限定润滑剂空间。 密封单元在润滑剂空间中保持润滑剂，并防止钻孔中的污染流体和材料进入润滑剂空间。 至少一个密封单元包括环形杯形弹性体密封件，其具有安装在辊切割器中的环形密封压盖中的环形唇缘。 密封压盖具有靠近润滑剂空间的内侧和暴露于流体的外侧和钻孔中的材料。 可压缩的填充材料环装配在杯状弹性体密封件的空腔中，并允许弹性体密封件变形，使得润滑剂空间中的内部压力向外通过密封件的环形唇缘，但允许外部压力 流体和钻孔中的材料，以迫使密封构件抵靠密封压盖的内侧，产生流体密封。

公开(公告)号：US06448275B2

公开(公告)日：2002-09-10

申请号：US09840117

申请日：2001-04-24

申请人： James W. Young

发明人： James W. Young

IPC分类号： A61K3144

CPC分类号： A61K31/44 ,  Y10S514/866 ,  Y10S514/929

摘要： Methods and compositions are disclosed utilizing the optically pure (−) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodipine. The (−) isomer of amlodipine is also useful for the treatment of angina and such other conditions as may be related to the activity of (−) amlodipine as a calcium channel antagonist such as cerebral ischemia, cerebral disorders, arrhythmias, cardiac hypertrophy, coronary vasospasm, myocardial infarction, renal impairment and acute renal failure, without the concomitant liability of adverse effects associated with the racemic mixture of amlodipine.

摘要翻译： 公开利用氨氯地平的光学纯（ - ）异构体的方法和组合物。 该化合物是治疗高血压的有效药物，同时避免与氨氯地平外消旋混合物相关的副作用的伴随责任。 氨氯地平的（ - ）异构体也可用于治疗心绞痛和其他可能与（ - ）氨氯地平作为钙通道拮抗剂如脑缺血，脑障碍，心律失常，心脏肥大，冠状动脉 血管痉挛，心肌梗塞，肾功能衰竭和急性肾功能衰竭，无与氨氯地平外消旋混合物相关的副作用的伴随责任。

公开(公告)号：US06436936B1

公开(公告)日：2002-08-20

申请号：US09121029

申请日：1998-07-22

申请人： James W. Young ,  Steven Brandt

发明人： James W. Young ,  Steven Brandt

IPC分类号： A61K31495

CPC分类号： A61K31/495

摘要： Methods and compositions are disclosed utilizing the optically pure (+) isomer of zopiclone. This compound is a potent drug for the treatment of sleep disorders, such as insomnia, and convulsive disorders, such as epilepsy. Similarly, these novel compositions and methods are useful for the treatment of sleep disorders and convulsive disorders while avoiding the concomitant liability of adverse effects associated with the racemic mixture of zopiclone. The optically pure (+) isomer of zopiclone is also useful for treating disorders that are affected by the binding of agonists to central nervous system or peripheral benzodiazepine receptors. Also described are methods and compositions for treating disorders that are affected by binding of agonists to central nervous system or peripheral benzodiazepine receptors while avoiding the adverse effects associated with the administration of the racemic mixture of zopiclone.

摘要翻译： 公开了使用佐匹克隆的光学纯（+）异构体的方法和组合物。 该化合物是治疗睡眠障碍（例如失眠）和惊厥性疾病如癫痫的有效药物。 类似地，这些新的组合物和方法可用于治疗睡眠障碍和惊厥性疾病，同时避免与佐匹克隆的外消旋混合物相关的副作用的伴随的责任。 佐匹克隆的光学纯（+）异构体也可用于治疗受激动剂与中枢神经系统或外周苯并二氮杂受体结合影响的疾病。 还描述了用于治疗受激动剂与中枢神经系统或外周苯并二氮杂受体的结合影响的疾病的方法和组合物，同时避免与佐匹克隆的外消旋混合物的施用相关的不利影响。

公开(公告)号：US06274595B1

公开(公告)日：2001-08-14

申请号：US09332197

申请日：1999-06-14

申请人： James W. Young ,  A. K. Gunnar Aberg

发明人： James W. Young ,  A. K. Gunnar Aberg

IPC分类号： A61K3147

CPC分类号： A61K31/47 ,  A61K31/496 ,  Y02A50/475 ,  Y02A50/481

摘要： Methods and compositions are disclosed utilizing the optically pure (S)-isomer of lomefloxacin to treat bacterial infection. In particular, this compound is a potent drug for the treatment of Mycobacteria infection.

摘要翻译： 公开了使用洛美沙星的光学纯（S） - 异构体来治疗细菌感染的方法和组合物。 特别地，该化合物是用于治疗分枝杆菌感染的有效药物。