公开(公告)号：US20050202077A1

公开(公告)日：2005-09-15

申请号：US11063391

申请日：2005-02-22

申请人： James Watson ,  J. Murison ,  Murray Grigor ,  Ilkka Havukkala ,  Grant Munro ,  Nevin Abernethy ,  Gill Webster

发明人： James Watson ,  J. Murison ,  Murray Grigor ,  Ilkka Havukkala ,  Grant Munro ,  Nevin Abernethy ,  Gill Webster

IPC分类号： A61K9/127 ,  A61K48/00 ,  C07H21/02 ,  C12N7/01 ,  C12N15/113 ,  C12N15/86 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

摘要： Compositions for the treatment and/or prevention of IgE-mediated disorders in a mammal by means of RNA interference are provided, together with methods for the use of such compounds. The inventive compositions comprise a binding agent that specifically binds to a target internalizable antigen that is expressed on the surface of a target cell of interest and a genetic construct that is capable of expressing a small interfering nucleic acid molecule (siNA) that suppresses expression of a target gene within the target cell, whereby, after binding to the target antigen, the binding agent and genetic construct are internalized into the cell, and the genetic construct released.

摘要翻译： 提供了通过RNA干扰治疗和/或预防哺乳动物中IgE介导的紊乱的组合物，以及使用这些化合物的方法。 本发明的组合物包含特异性结合目标细胞表面上表达的靶可内在抗原的结合剂和能够表达抑制表达的小干扰核酸分子（siNA）的遗传构建体 目标基因，由此，在与靶抗原结合之后，将结合剂和遗传构建体内化到细胞中，释放遗传构建体。