公开(公告)号：US20050202077A1

公开(公告)日：2005-09-15

申请号：US11063391

申请日：2005-02-22

申请人： James Watson ,  J. Murison ,  Murray Grigor ,  Ilkka Havukkala ,  Grant Munro ,  Nevin Abernethy ,  Gill Webster

发明人： James Watson ,  J. Murison ,  Murray Grigor ,  Ilkka Havukkala ,  Grant Munro ,  Nevin Abernethy ,  Gill Webster

IPC分类号： A61K9/127 ,  A61K48/00 ,  C07H21/02 ,  C12N7/01 ,  C12N15/113 ,  C12N15/86 ,  C12Q1/68

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

摘要： Compositions for the treatment and/or prevention of IgE-mediated disorders in a mammal by means of RNA interference are provided, together with methods for the use of such compounds. The inventive compositions comprise a binding agent that specifically binds to a target internalizable antigen that is expressed on the surface of a target cell of interest and a genetic construct that is capable of expressing a small interfering nucleic acid molecule (siNA) that suppresses expression of a target gene within the target cell, whereby, after binding to the target antigen, the binding agent and genetic construct are internalized into the cell, and the genetic construct released.

摘要翻译： 提供了通过RNA干扰治疗和/或预防哺乳动物中IgE介导的紊乱的组合物，以及使用这些化合物的方法。 本发明的组合物包含特异性结合目标细胞表面上表达的靶可内在抗原的结合剂和能够表达抑制表达的小干扰核酸分子（siNA）的遗传构建体 目标基因，由此，在与靶抗原结合之后，将结合剂和遗传构建体内化到细胞中，释放遗传构建体。

公开(公告)号：US20050009750A1

公开(公告)日：2005-01-13

申请号：US10885225

申请日：2004-07-06

申请人： Matthew Sleeman ,  J. Murison ,  Zhihui Cao

发明人： Matthew Sleeman ,  J. Murison ,  Zhihui Cao

IPC分类号： C07H21/04 ,  C07K14/71 ,  A61K38/17

CPC分类号： C07K14/71 ,  C07H21/04

摘要： Isolated fibroblast growth factor receptor 5 (FGFR5) polypeptides are provided, together with polynucleotides encoding such polypeptides. Also provided are modulators of FGFR5 gene expression and binding molecules that specifically bind to, and agonize or antagonize, FGFR5 polypeptide function. Binding molecules include antibodies, and functional fragments thereof, as well as scFv and Camelidae heavy chain IgG that specifically bind to FGFR5 thereby modulating the activity of FGFR5. Such binding agents and modulators of FGFR5 gene expression may be employed for the treatment of disorders including: osteopontin-mediated diseases; autoimmune diseases, such as systemic lupus erythematosus; bone disorders such as osteoporosis and osteopetrosis; and cancers, including cellular carcinomas such as hepatocellular carcinomas.

公开(公告)号：US20070110752A1

公开(公告)日：2007-05-17

申请号：US11591993

申请日：2006-11-01

申请人： J. Murison ,  Zhihui Cao

发明人： J. Murison ,  Zhihui Cao

IPC分类号： A61K39/395 ,  A61K48/00

CPC分类号： C07K14/71 ,  A61K38/00 ,  C12N15/1138 ,  C12N2310/11

摘要： Isolated fibroblast growth factor receptor 5 (FGFR5) polypeptides are provided, together with polynucleotides encoding such polypeptides. Also provided are modulators of FGFR5 gene expression and binding molecules that specifically bind to, and agonize or antagonize, FGFR5 polypeptide finction. Binding molecules include antibodies, and functional fragments thereof, as well as scFv and Camelidae heavy chain IgG that specifically bind to FGFR5 thereby modulating the activity of FGFR5. Such binding agents and modulators of FGFR5 gene expression may be employed for the treatment of disorders including: osteopontin-mediated diseases; autoimmune diseases, such as systemic lupus erythematosus; bone disorders such as osteoporosis and osteopetrosis; and cancers, including cellular carcinomas such as hepatocellular carcinomas.

摘要翻译： 分离的成纤维细胞生长因子受体5（FGFR5）多肽与编码这种多肽的多核苷酸一起提供。 还提供了FGFR5基因表达的调节剂和特异性结合并激动或拮抗FGFR5多肽功能的结合分子。 结合分子包括抗体及其功能片段，以及特异性结合FGFR5的scFv和骆驼科重链IgG，从而调节FGFR5的活性。 FGFR5基因表达的这种结合剂和调节剂可用于治疗疾病，包括：骨桥蛋白介导的疾病; 自身免疫性疾病，如系统性红斑狼疮; 骨质疏松症和骨硬化等骨质疏松症; 和癌症，包括细胞癌如肝细胞癌。

公开(公告)号：US20060115483A1

公开(公告)日：2006-06-01

申请号：US11154977

申请日：2005-06-15

申请人： Matthew Sleeman ,  J. Murison ,  Zhihui Cao

发明人： Matthew Sleeman ,  J. Murison ,  Zhihui Cao

IPC分类号： C07K14/82 ,  C07K16/30 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395

CPC分类号： C07K16/2863 ,  C07K14/71 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/30

摘要： Isolated fibroblast growth factor receptor 5 (FGFR5) polypeptides are provided, together with polynucleotides encoding such polypeptides. Also provided are modulators of FGFR5 gene expression and binding molecules that specifically bind to, and agonize or antagonize, FGFR5 polypeptide function. Binding molecules include antibodies, and functional fragments thereof, as well as scFv and Camelidae heavy chain IgG that specifically bind to FGFR5 thereby modulating the activity of FGFR5. Such binding agents and modulators of FGFR5 gene expression may be employed for the treatment of disorders including: osteopontin-mediated diseases; autoimmune diseases, such as systemic lupus erythematosus; bone disorders such as osteoporosis and osteopetrosis; and cancers, including cellular carcinomas such as hepatocellular carcinomas.

摘要翻译： 分离的成纤维细胞生长因子受体5（FGFR5）多肽与编码这种多肽的多核苷酸一起提供。 还提供了FGFR5基因表达的调节剂和特异性结合并激动或拮抗FGFR5多肽功能的结合分子。 结合分子包括抗体及其功能片段，以及特异性结合FGFR5的scFv和骆驼科重链IgG，从而调节FGFR5的活性。 FGFR5基因表达的这种结合剂和调节剂可用于治疗疾病，包括：骨桥蛋白介导的疾病; 自身免疫性疾病，如系统性红斑狼疮; 骨质疏松症和骨硬化等骨质疏松症; 和癌症，包括细胞癌如肝细胞癌。

公开(公告)号：US20050112642A1

公开(公告)日：2005-05-26

申请号：US10954094

申请日：2004-09-29

申请人： Matthew Sleeman ,  J. Murison ,  Zhihui Cao

发明人： Matthew Sleeman ,  J. Murison ,  Zhihui Cao

IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K14/71 ,  C07K16/28 ,  C12Q1/68

CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/2863 ,  C07K2319/00

摘要： Isolated fibroblast growth factor receptor 5 (FGFR5) polypeptides are provided, together with polynucleotides encoding such polypeptides. Also provided are modulators of FGFR5 gene expression and binding molecules that specifically bind to, and agonize or antagonize, FGFR5 polypeptide function. Binding molecules include antibodies, and functional fragments thereof, as well as scFv and Camelidae heavy chain IgG that specifically bind to FGFR5 thereby modulating the activity of FGFR5. Such binding agents and modulators of FGFR5 gene expression may be employed for the treatment of disorders including: osteopontin-mediated diseases; autoimmune diseases, such as systemic lupus erythematosus; bone disorders such as osteoporosis and osteopetrosis; and cancers, including cellular carcinomas such as hepatocellular carcinomas.

摘要翻译： 分离的成纤维细胞生长因子受体5（FGFR5）多肽与编码这种多肽的多核苷酸一起提供。 还提供了FGFR5基因表达的调节剂和特异性结合并激动或拮抗FGFR5多肽功能的结合分子。 结合分子包括抗体及其功能片段，以及特异性结合FGFR5的scFv和骆驼科重链IgG，从而调节FGFR5的活性。 FGFR5基因表达的这种结合剂和调节剂可用于治疗疾病，包括：骨桥蛋白介导的疾病; 自身免疫性疾病，如系统性红斑狼疮; 骨质疏松症和骨硬化等骨质疏松症; 和癌症，包括细胞癌如肝细胞癌。