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    Vascular targets for detecting, imaging and treating neoplasia or neovasculature
    1.
    发明授权
    Vascular targets for detecting, imaging and treating neoplasia or neovasculature 有权
    用于检测，成像和治疗肿瘤或新生血管的血管靶

    公开(公告)号：US08715675B2

    公开(公告)日：2014-05-06

    申请号：US12766062

    申请日：2010-04-23

    申请人： Jan E. Schnitzer ,  Philip Oh

    发明人： Jan E. Schnitzer ,  Philip Oh

    IPC分类号： A61K39/395

    CPC分类号： A61K38/1709 ,  A61K2039/505 ,  C07K16/18

    摘要： Methods of delivering an agent in a tissue-specific manner, by targeting annexin A1, a derivative of annexin A1, or a binding partner of annexin A1, are described. The methods can be used for detecting, imaging and/or treating neoplasia, angiogenesis or neovasculature, as well as for diagnostics and methods of assessing treatment efficacy. Antibodies to annexin A1 are also described, as are methods screening for agents altering annexin A1 activity.

    摘要翻译： 描述了通过靶向膜联蛋白A1，膜联蛋白A1的衍生物或膜联蛋白A1的结合配偶体以组织特异性方式递送药剂的方法。 该方法可用于检测，成像和/或治疗瘤形成，血管生成或新血管系统，以及评估治疗功效的诊断和方法。 还描述了膜联蛋白A1的抗体，以及筛选改变膜联蛋白A1活性的药剂的方法。

    Tissue-specific imaging and therapeutic agents targeting proteins expressed on lung endothelial cell surface
    3.
    发明授权
    Tissue-specific imaging and therapeutic agents targeting proteins expressed on lung endothelial cell surface 有权
    针对在内皮细胞表面表达的蛋白质的组织特异性成像和治疗剂

    公开(公告)号：US08815235B2

    公开(公告)日：2014-08-26

    申请号：US11143114

    申请日：2005-06-02

    申请人： Jan E. Schnitzer ,  Philip Oh

    发明人： Jan E. Schnitzer ,  Philip Oh

    IPC分类号： A61K39/395

    CPC分类号： A61K47/6849

    摘要： Methods of delivering an agent in a tissue-specific manner, particularly lung tissue, by targeting a protein expressed on the endothelial cell surface, are described. The methods can be used for detecting, imaging and/or treating pathologies, as well as for diagnostics.

    摘要翻译： 描述了通过靶向内皮细胞表面上表达的蛋白质以组织特异性方式递送药剂的方法，特别是肺组织。 该方法可用于检测，成像和/或治疗病理学以及诊断。

    Immunoisolation of caveolae
    5.
    发明授权
    Immunoisolation of caveolae 失效
    穴状病毒的免疫隔离

    公开(公告)号：US06737516B1

    公开(公告)日：2004-05-18

    申请号：US09208195

    申请日：1998-12-09

    申请人： Jan E. Schnitzer ,  Philip Oh

    发明人： Jan E. Schnitzer ,  Philip Oh

    IPC分类号： A23J100

    CPC分类号： G01N33/5308

    摘要： Method of producing purified caveolae are described, in which a sample of interest comprising plasma membranes is subjected to an immunoisolation method in which the sample of interest is incubated with an antibody that is specific for caveolin and which binds to caveolin in its native (oligomeric) state, preferably for a brief time period, and caveolae that are bound to the antibody are separated from other materials in the sample of interest. Purified caveolae produced by the methods, and uses for the purified caveolae, are also described.

    摘要翻译： 描述了产生纯化的细胞膜穴状病毒的方法，其中将包含质膜的感兴趣的样品进行免疫隔离方法，其中将感兴趣的样品与特异于小窝蛋白的抗体一起孵育，并结合其天然（寡聚）的小窝蛋白， 状态，优选短暂的时间段，并且与抗体结合的小室游离体与感兴趣的样品中的其它物质分离。 还描述了通过该方法产生的净化的穴状病毒，以及用于纯化的小窝穴病毒的用途。

    Vascular targets for detecting, imaging and treating neoplasia or neovasculature
    6.
    发明申请
    Vascular targets for detecting, imaging and treating neoplasia or neovasculature 审中-公开
    用于检测，成像和治疗肿瘤或新生血管的血管靶

    公开(公告)号：US20060024315A1

    公开(公告)日：2006-02-02

    申请号：US11143886

    申请日：2005-06-02

    申请人： Jan Schnitzer ,  Philip Oh

    发明人： Jan Schnitzer ,  Philip Oh

    IPC分类号： A61K39/395

    CPC分类号： A61K38/1709 ,  A61K2039/505 ,  C07K16/18

    摘要： Methods of delivering an agent in a tissue-specific manner, by targeting annexin A1, a derivative of annexin A1, or a binding partner of annexin A1, are described. The methods can be used for detecting, imaging and/or treating neoplasia, angiogenesis or neovasculature, as well as for diagnostics and methods of assessing treatment efficacy. Antibodies to annexin A1 are also described, as are methods screening for agents altering annexin A1 activity.

    摘要翻译： 描述了通过靶向膜联蛋白A1，膜联蛋白A1的衍生物或膜联蛋白A1的结合配偶体以组织特异性方式递送药剂的方法。 该方法可用于检测，成像和/或治疗瘤形成，血管生成或新血管系统，以及评估治疗功效的诊断和方法。 还描述了膜联蛋白A1的抗体，以及筛选改变膜联蛋白A1活性的药剂的方法。