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    RED BLOOD CELL MEMBRANE-DERIVED MICROPARTICLES AND THEIR USE FOR THE TREATMENT OF LUNG DISEASE
    1.
    发明申请
    RED BLOOD CELL MEMBRANE-DERIVED MICROPARTICLES AND THEIR USE FOR THE TREATMENT OF LUNG DISEASE 有权
    红血球细胞膜衍生的微生物及其用于治疗肺疾病的用途

    公开(公告)号：US20160263156A1

    公开(公告)日：2016-09-15

    申请号：US15034700

    申请日：2014-11-06

    申请人： Janet S. Lee ,  Timothy E. Corcoran ,  Valerian Kagan

    发明人： Janet S. Lee ,  Timothy E. Corcoran ,  Valerian Kagan

    IPC分类号： A61K35/18 ,  A61K9/14 ,  A61K9/127 ,  A61K9/00

    CPC分类号： A61K35/18 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/127 ,  A61K9/14 ,  A61K2035/124 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907

    摘要： Cell-based therapies show considerable potential as an immunomodulatory strategy for a variety of lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis, acute lung injury, lung allograft rejection (acute or chronic), pulmonary fibrosis. Described herein is the development of red blood cell membrane-derived microparticles (RBC MPs), which are depleted of hemoglobin (Hb) and express phosphatidylserine on their surface, for the treatment of lung disease. Administration of RBC MPs to the lung via inhalation promotes the production of immunoregulatory cytokines (such as IL-10), and reduces inflammation and injury in the lung.

    摘要翻译： 基于细胞的疗法作为各种肺部疾病（包括慢性阻塞性肺疾病（COPD），哮喘，细支气管炎，急性肺损伤，肺同种异体移植排斥（急性或慢性）），肺纤维化的免疫调节策略具有显着的潜力。 本文描述的是红细胞膜衍生的微粒（RBC MPs）的发展，其在其表面上耗尽血红蛋白（Hb）并表达磷脂酰丝氨酸用于治疗肺部疾病。 通过吸入将RBC MPs给予肺促进免疫调节细胞因子（例如IL-10）的产生，并减少肺中的炎症和损伤。

    RADIOPROTECTIVE AGENTS
    2.
    发明申请
    RADIOPROTECTIVE AGENTS 有权
    放射防护剂

    公开(公告)号：US20110288178A1

    公开(公告)日：2011-11-24

    申请号：US13124924

    申请日：2009-10-21

    申请人： Michael Epperly ,  Joel Greenberger ,  Jianfei Jiang ,  Valerian Kagan ,  John Lazo ,  Peter McDonald

    发明人： Michael Epperly ,  Joel Greenberger ,  Jianfei Jiang ,  Valerian Kagan ,  John Lazo ,  Peter McDonald

    IPC分类号： A61K31/17 ,  A61P39/00

    CPC分类号： A61K31/64

    摘要： Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate apoptosis. The compounds comprise glyburide or other sulfonylurea hypoglycemic compounds or potassium channel inhibitors.

    摘要翻译： 本文提供了减少，预防，减轻和治疗由辐射引起的损害的方法。 所述方法包括以有效预防，减轻或治疗由辐射引起的损伤或减轻细胞凋亡的量和剂量方案向患者递送本文所述的化合物。 化合物包括格列本脲或其他磺酰脲降血糖化合物或钾通道抑制剂。

    Use of targeted nitroxide agents in mitigating or treating radiation injury
    4.
    发明授权
    Use of targeted nitroxide agents in mitigating or treating radiation injury 有权
    使用靶向的氮氧化物剂减轻或治疗放射性损伤

    公开(公告)号：US08822541B2

    公开(公告)日：2014-09-02

    申请号：US13006640

    申请日：2011-01-14

    申请人： Peter Wipf ,  Natalia A. Belikova ,  Jianfei Jiang ,  Joshua Pierce ,  Joel Greenberger ,  Michael Epperly ,  Valerian Kagan

    发明人： Peter Wipf ,  Natalia A. Belikova ,  Jianfei Jiang ,  Joshua Pierce ,  Joel Greenberger ,  Michael Epperly ,  Valerian Kagan

    IPC分类号： A61K31/13

    CPC分类号： A61K31/13 ,  A61K31/15

    摘要： Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

    摘要翻译： 本文提供了可用于自由基清除的组合物和相关方法，对线粒体具有特别的选择性。 化合物包含连接到线粒体靶向基团的含氮氧基的基团。 化合物可以交联成二聚体而不损失活性。 本文还提供了用于防止，减轻和治疗由辐射引起的损伤的方法。 该方法包括以有效预防，减轻或治疗由辐射引起的损伤的量和剂量方案将如本文所述的化合物递送至患者。