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    Use of targeted nitroxide agents in mitigating or treating radiation injury
    1.
    发明授权
    Use of targeted nitroxide agents in mitigating or treating radiation injury 有权
    使用靶向的氮氧化物剂减轻或治疗放射性损伤

    公开(公告)号：US08822541B2

    公开(公告)日：2014-09-02

    申请号：US13006640

    申请日：2011-01-14

    申请人： Peter Wipf ,  Natalia A. Belikova ,  Jianfei Jiang ,  Joshua Pierce ,  Joel Greenberger ,  Michael Epperly ,  Valerian Kagan

    发明人： Peter Wipf ,  Natalia A. Belikova ,  Jianfei Jiang ,  Joshua Pierce ,  Joel Greenberger ,  Michael Epperly ,  Valerian Kagan

    IPC分类号： A61K31/13

    CPC分类号： A61K31/13 ,  A61K31/15

    摘要： Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

    摘要翻译： 本文提供了可用于自由基清除的组合物和相关方法，对线粒体具有特别的选择性。 化合物包含连接到线粒体靶向基团的含氮氧基的基团。 化合物可以交联成二聚体而不损失活性。 本文还提供了用于防止，减轻和治疗由辐射引起的损伤的方法。 该方法包括以有效预防，减轻或治疗由辐射引起的损伤的量和剂量方案将如本文所述的化合物递送至患者。

    CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN
    7.
    发明申请
    CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN 有权
    抑制FTSZ蛋白的CHRYSOPHAENTIN模拟物

    公开(公告)号：US20130331460A1

    公开(公告)日：2013-12-12

    申请号：US14000761

    申请日：2012-02-24

    申请人： Carole A. Bewley ,  Peter Wipf

    发明人： Carole A. Bewley ,  Peter Wipf

    IPC分类号： C07C39/373 ,  A61K45/06 ,  C07C37/14 ,  A61K31/055

    CPC分类号： C07C37/14 ,  A61K31/055 ,  A61K31/085 ,  A61K45/06 ,  C07C39/373 ,  C07C43/23 ,  C07D321/00 ,  Y02A50/473

    摘要： Embodiments of antimicrobial chrysophaentin compounds, pharmaceutical compositions including the chrysophaentin compounds, methods for using the chrysophaentin compounds, and methods for synthesizing the chrysophaentin compounds are disclosed. Certain embodiments of the chrysophaentin compounds inhibit FtsZ protein, thereby inhibiting the growth of clinically relevant bacteria, including drug-resistant strains.

    摘要翻译： 公开了抗微生物菌素化合物的实施方案，包括辣椒素化合物的药物组合物，使用辣椒素化合物的方法，以及合成辣椒素化合物的方法。 辣椒素化合物的某些实施方案抑制FtsZ蛋白，从而抑制临床相关细菌（包括耐药菌株）的生长。

    Targeted nitroxide agents
    8.
    发明授权
    Targeted nitroxide agents 有权
    目标氮氧化物

    公开(公告)号：US08288551B2

    公开(公告)日：2012-10-16

    申请号：US12505294

    申请日：2009-07-17

    申请人： Peter Wipf ,  Marie Celine Frantz

    发明人： Peter Wipf ,  Marie Celine Frantz

    IPC分类号： C07D211/00 ,  A61K31/445

    CPC分类号： C07K5/08 ,  A61K31/454 ,  A61K47/64 ,  C07C237/16 ,  C07D209/44 ,  C07D209/46 ,  C07D211/58 ,  C07D211/94 ,  C07D221/22 ,  C07D279/06 ,  C07D401/12 ,  C07D417/12 ,  C07D471/08

    摘要： Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

    摘要翻译： 本文提供了可用于自由基清除的组合物和相关方法，对线粒体具有特别的选择性。 化合物包含连接到线粒体靶向基团的含氮氧基的基团。 化合物可以交联成二聚体而不损失活性。 本文还提供了用于防止，减轻和治疗由辐射引起的损伤的方法。 该方法包括以有效预防，减轻或治疗由辐射引起的损伤的量和剂量方案将如本文所述的化合物递送至患者。

    SELECTIVE TARGETING AGENTS FOR MITOCHONDRIA
    10.
    发明申请
    SELECTIVE TARGETING AGENTS FOR MITOCHONDRIA 有权
    MITOCHONDRIA的选择性目标代理

    公开(公告)号：US20070161573A1

    公开(公告)日：2007-07-12

    申请号：US11465162

    申请日：2006-08-17

    申请人： Peter Wipf ,  Jingbo Xiao ,  Mitchell P. Fink ,  Valerian E. Kagan ,  Yulia Y. Tyurina

    发明人： Peter Wipf ,  Jingbo Xiao ,  Mitchell P. Fink ,  Valerian E. Kagan ,  Yulia Y. Tyurina

    IPC分类号： A61K38/06 ,  A61K38/05 ,  A61K31/445

    CPC分类号： A61K31/445 ,  A61K47/55 ,  A61K47/64

    摘要： Compositions and methods are disclosed for treating an illness that is caused or associated with cellular damage or dysfunction which is caused by excessive mitochondrial production of reaction oxygen species (ROS). Compositions which act as mitochondria-selective targeting agents using specific structural signaling features recognizable by cells as mitochondrial targeting sequences are discussed. A method for delivering these agents effectively into cells and mitochondria where they act as electron scavengers by way of certain targeting sequences is also disclosed. Mitochondria dysfunction and cell death by way of apoptosis is inhibited as a result of the ROS-scavenging activity, thereby increasing the survival rate of the patient. In a preferred embodiment, the compositions and methods may be administered therapeutically in the field to patients with profound hemorrhagic shock so that survival could be prolonged until it is feasible to obtain surgical control of the bleeding vessels.

    摘要翻译： 公开了用于治疗由反应氧物质（ROS）的过量线粒体产生引起的与细胞损伤或功能障碍相关的疾病的组合物和方法。 讨论了使用细胞可被线粒体靶向序列识别的特异性结构信号特征作为线粒体选择性靶向剂的组合物。 还公开了一种将这些试剂有效地递送到细胞和线粒体中的方法，其中它们通过某些靶向序列作为电子清除剂。 由于ROS清除活性，线粒体功能障碍和凋亡细胞死亡被抑制，从而增加患者的存活率。 在优选的实施方案中，组合物和方法可以在现场给予具有严重出血性休克的患者的治疗上，使得可以延长存活直到获得出血血管的手术控制。