公开(公告)号：US07976825B2

公开(公告)日：2011-07-12

申请号：US12315951

申请日：2008-12-08

申请人： Janos Borbely ,  Magdolna Bodnar ,  John F Hartmann ,  Istvan Hajdu ,  Jozsef Kollar ,  Gyorgy Vamosi

发明人： Janos Borbely ,  Magdolna Bodnar ,  John F Hartmann ,  Istvan Hajdu ,  Jozsef Kollar ,  Gyorgy Vamosi

IPC分类号： A61B5/055 ,  A61B49/04 ,  A61K9/50

CPC分类号： A61K31/519 ,  A61K31/7088 ,  A61K49/1824 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/93

摘要： Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular relaxivity of carriers. The synthesis of biomolecular based nanodevices for targeted delivery of MRI contrast agents are described. Nanoparticles (NP) have been constructed by self-assembling of chitosan (CHIT) as polycation and poly-gamma glutamic acids (PGA) as polyanion. NP's are capable of Gd-ion uptake forming a particle with suitable molecular relaxivity. Folic acid (FA) is linked to the NP's to produce NP-FA bioconjugates that can be used for targeted in vitro delivery to a human cancer cell line.

摘要翻译： 描述了用于磁共振成像的大分子造影剂。 生物分子及其修饰的衍生物与顺磁离子形成稳定的络合物，从而增加载体的分子弛豫性。 描述了用于靶向递送MRI造影剂的基于生物分子的纳米装置的合成。 纳米颗粒（NP）已经通过壳聚糖（CHIT）作为聚阳离子和聚-γ谷氨酸（PGA）作为聚阴离子自组装而构建。 NP能够进行Gd离子吸收，形成具有合适分子弛豫性的颗粒。 叶酸（FA）与NP连接以产生可用于靶向体外递送至人癌细胞系的NP-FA生物缀合物。

公开(公告)号：US20090180966A1

公开(公告)日：2009-07-16

申请号：US12315951

申请日：2008-12-08

申请人： Janos Borbely ,  Magdolna Bodnar ,  John F. Hartmann ,  Istvan Hajdu ,  Jozsef Kollar ,  Gyorgy Vamosi

发明人： Janos Borbely ,  Magdolna Bodnar ,  John F. Hartmann ,  Istvan Hajdu ,  Jozsef Kollar ,  Gyorgy Vamosi

IPC分类号： A61K9/14 ,  A61P43/00

CPC分类号： A61K31/519 ,  A61K31/7088 ,  A61K49/1824 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/93

摘要： Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular relaxivity of carriers. The synthesis of biomolecular based nanodevices for targeted delivery of MRI contrast agents are described. Nanoparticles (NP) have been constructed by self-assembling of chitosan (CHIT) as polycation and poly-gamma glutamic acids (PGA) as polyanion. NP's are capable of Gd-ion uptake forming a particle with suitable molecular relaxivity. Folic acid (FA) is linked to the NP's to produce NP-FA bioconjugates that can be used for targeted in vitro delivery to a human cancer cell line.

摘要翻译： 描述了用于磁共振成像的大分子造影剂。 生物分子及其修饰的衍生物与顺磁离子形成稳定的络合物，从而增加载体的分子弛豫性。 描述了用于靶向递送MRI造影剂的基于生物分子的纳米装置的合成。 纳米颗粒（NP）已经通过壳聚糖（CHIT）作为聚阳离子和聚-γ谷氨酸（PGA）作为聚阴离子自组装而构建。 NP能够进行Gd离子吸收，形成具有合适分子弛豫性的颗粒。 叶酸（FA）与NP连接以产生可用于靶向体外递送至人癌细胞系的NP-FA生物缀合物。