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公开(公告)号：US07740883B2
公开(公告)日：2010-06-22
申请号：US11091940
申请日：2005-03-28
申请人： Janos Borbely , Magdolna Bodnar
发明人： Janos Borbely , Magdolna Bodnar
IPC分类号： C08B37/08
CPC分类号： C08B37/003 , A61K9/5161 , A61K9/5192 , A61K47/36 , B01J13/14 , B82Y30/00
摘要： Methods are disclosed for preparing crosslinked core and core-shell nanoparticle polymers from chitosan. The final products of the present invention may be used as detergents and as additives for pharmaceutical composition and for drug delivery, and DNA carrier system. The nanoparticles made from biopolymers of the present invention may also be used in controlled release, superabsorbent materials and biomaterials like enzyme immobilization.
摘要翻译： 公开了从壳聚糖制备交联核心和核 - 壳纳米颗粒聚合物的方法。 本发明的最终产品可用作洗涤剂和用作药物组合物和药物递送的添加剂以及DNA载体体系。 由本发明的生物聚合物制成的纳米颗粒也可用于控制释放，超吸收材料和诸如酶固定的生物材料。
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公开(公告)号：US20080237135A1
公开(公告)日：2008-10-02
申请号：US11601384
申请日：2006-11-17
CPC分类号： C02F1/683 , C02F2101/20 , Y10T428/2982
摘要： Methods are disclosed for preparing novel biodegradable nanoparticles based on complexation of poly-gamma-glutamic acid (γ-PGA) or its cross-linked derivatives with bivalent lead ions. The final products are stable in aqueous media at low pH, neutral and mild alkaline conditions. The size of the complexes depends on the pH, concentrations and the ratios of γ-PGA and lead ionsThe γ-PGA nanoparticles made from biodegradable biopolymers with high flocculating and heavy metal binding activity of the present invention may be used for various water treatment applications in aqueous media.
摘要翻译： 公开了基于聚-γ-谷氨酸（γ-PGA）或其交联衍生物与二价铅离子的络合制备新的可生物降解纳米颗粒的方法。 最终产物在低pH，中性和弱碱性条件下在水性介质中是稳定的。 复合物的大小取决于pH，浓度和γ-PGA和铅离子的比例。本发明的具有高絮凝和重金属结合活性的可生物降解的生物聚合物制成的γ-PGA纳米颗粒可用于各种水处理应用 在水性介质中。
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公开(公告)号：US07976825B2
公开(公告)日：2011-07-12
申请号：US12315951
申请日：2008-12-08
申请人： Janos Borbely , Magdolna Bodnar , John F Hartmann , Istvan Hajdu , Jozsef Kollar , Gyorgy Vamosi
发明人： Janos Borbely , Magdolna Bodnar , John F Hartmann , Istvan Hajdu , Jozsef Kollar , Gyorgy Vamosi
CPC分类号： A61K31/519 , A61K31/7088 , A61K49/1824 , B82Y5/00 , Y10S977/773 , Y10S977/93
摘要： Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular relaxivity of carriers. The synthesis of biomolecular based nanodevices for targeted delivery of MRI contrast agents are described. Nanoparticles (NP) have been constructed by self-assembling of chitosan (CHIT) as polycation and poly-gamma glutamic acids (PGA) as polyanion. NP's are capable of Gd-ion uptake forming a particle with suitable molecular relaxivity. Folic acid (FA) is linked to the NP's to produce NP-FA bioconjugates that can be used for targeted in vitro delivery to a human cancer cell line.
摘要翻译： 描述了用于磁共振成像的大分子造影剂。 生物分子及其修饰的衍生物与顺磁离子形成稳定的络合物，从而增加载体的分子弛豫性。 描述了用于靶向递送MRI造影剂的基于生物分子的纳米装置的合成。 纳米颗粒（NP）已经通过壳聚糖（CHIT）作为聚阳离子和聚-γ谷氨酸（PGA）作为聚阴离子自组装而构建。 NP能够进行Gd离子吸收，形成具有合适分子弛豫性的颗粒。 叶酸（FA）与NP连接以产生可用于靶向体外递送至人癌细胞系的NP-FA生物缀合物。
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公开(公告)号：US20080004402A1
公开(公告)日：2008-01-03
申请号：US11900191
申请日：2007-09-10
申请人： Janos Borbely , Andrea Uveges , Mihaly Szatmatri
发明人： Janos Borbely , Andrea Uveges , Mihaly Szatmatri
IPC分类号： C08F297/02
CPC分类号： C08F285/00 , C08F8/32 , C08F257/02 , C08F265/04 , C08F265/06 , C08F2800/20 , C08F2810/20
摘要： The present invention relates to core/shell vinyl polymers wherein an at least partially crosslinked core is formed from a monovinyl monomer and/or a di/tri/ or higher multivinyl monomer wherein the degree of crosslinking in the core ranges from slight to high depending on the ratio of monovinyl and/or di/tri/ or higher multivinyl monomers, and wherein the outer shell is formed from a monovinyl and/or a di/tri/ or higher multi-vinyl monomer that optionally may be crosslinked, and wherein the outer shell has on its surface linear or branched C.sub.3-C.sub.30 alkyl chains formed from substituted vinyl monomers.
摘要翻译： 本发明涉及核/壳乙烯基聚合物，其中至少部分交联的芯由单乙烯基单体和/或二/三或更高的多乙烯基单体形成，其中芯的交联度范围从轻到高，取决于 单乙烯基和/或二/三个或更多个多乙烯基单体的比例，并且其中外壳由任选地可以交联的单乙烯基和/或二/三或更高的多乙烯基单体形成，并且其中外层 壳在其表面上具有由取代的乙烯基单体形成的直链或支链C 3 -C 30烷基链。
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公开(公告)号：US20060246096A1
公开(公告)日：2006-11-02
申请号：US11406208
申请日：2004-12-29
申请人： Levente Novak , Eva Fleischer , Janos Borbely
发明人： Levente Novak , Eva Fleischer , Janos Borbely
CPC分类号： A61K9/5146 , A61K9/19 , A61K47/34
摘要： Methods are disclosed for preparing core-shell polymers of poly-γ-glutamic acid. The final products of the present invention are useful as drug delivery systems, for gene therapy, magnetic resonance imaging as well as in encapsulation technology. A method of forming a poly-γ-glutamic acid (PGA) useful in the formation of core shell polymers is disclosed. According to the method a PGA is prepared by fermentation with a suitable microorganism, capable of producing PGA in a suitable fermentation medium, under conditions and time appropriate for the microorganism used. The resulting culture medium is treated with centrifugation, to separate the cells from the PGA. Acetone is used to treat the resulting cell-free liquid to obtain the PGA from the fermentation medium. The obtained PGA is purified by dialysis and freeze drying the PGA. A method of forming a core shell polymer of a poly-γ-glutamic acid (PGA) is also disclosed. The core is formed by partially amidating a poly-γ-glutamic acid (PGA) by reaction with a diamino compound to at least partially cross-link the PGA. The outer shell of the core shell polymer is formed from a hydrophilic or a hydrophobic polymer.
摘要翻译： 公开了制备聚-γ-谷氨酸的核 - 壳聚合物的方法。 本发明的最终产品可用作药物递送系统，用于基因治疗，磁共振成像以及封装技术。 公开了一种形成用于形成核壳聚合物的聚-γ-谷氨酸（PGA）的方法。 根据该方法，通过在合适的微生物发酵能够在合适的发酵培养基中生产PGA，在适合所用微生物的条件和时间下制备PGA。 通过离心处理所得培养基，将细胞与PGA分离。 丙酮用于处理所得到的无细胞液体，从发酵培养基中获得PGA。 所得到的PGA通过透析纯化并冷冻干燥PGA。 还公开了形成聚-γ-谷氨酸（PGA）的核壳聚合物的方法。 通过与二氨基化合物反应部分酰化聚-γ-谷氨酸（PGA）以至少部分地交联PGA而形成核心。 芯壳聚合物的外壳由亲水或疏水聚合物形成。
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公开(公告)号：US20140099266A1
公开(公告)日：2014-04-10
申请号：US13944742
申请日：2013-07-17
IPC分类号： A61K49/18
CPC分类号： A61K49/1881 , A61K49/1833 , A61K49/1863 , A61K49/1872
摘要： Targeting contrast agent for magnetic resonance imaging (MRI). In preferred embodiments, self-assembled polyelectrolytes coated superparamagnetic iron oxide contrast agent particles are provided, which are labeled with targeting moieties, afforded enhanced relaxivity, improved signal-to-noise and targeting ability. Accordingly, the invention relates to a stable targeting contrast nanosystem applicable for magnetic resonance imaging (MRI) having at least one nanoparticle polyelectrolyte polyanion; a targeting agent conjugated to the biopolymer; and a superparamagnetic ligand. In another embodiment the nanosystem according to the invention has at least two biocompatible and biodegradable nanoparticle polyelectrolyte biopolymer. Particularly, the superparamagnetic iron oxide particles are coated by a polyelectrolyte biopolymer and this system self-assembles with the other biopolymer to produce stable nanosystem for magnetic resonance imaging. Targeting moieties are conjugated to a biopolymer or to the self-assembled biopolymers to realize a targeted delivery of contrast agent. Methods for making these targeting MRI contrast agents are also provided.
摘要翻译： 用于磁共振成像（MRI）的靶向造影剂。 在优选的实施方案中，提供了自组装聚电解质涂覆的超顺磁性氧化铁对比剂颗粒，其被靶向部分标记，提供增强的弛豫度，改进的信噪比和靶向能力。 因此，本发明涉及适用于具有至少一种纳米颗粒聚电解质聚阴离子的磁共振成像（MRI）的稳定靶向对比纳米系统; 与生物聚合物缀合的靶向剂; 和超顺磁配体。 在另一个实施方案中，根据本发明的纳米系统具有至少两种生物相容性和可生物降解的纳米粒子聚电解质生物聚合物。 特别地，超顺磁性氧化铁颗粒由聚电解质生物聚合物涂覆，并且该系统与其他生物聚合物自组装，以产生用于磁共振成像的稳定的纳米系统。 靶向部分与生物聚合物或自组装生物聚合物缀合以实现造影剂的靶向递送。 还提供了制备这些靶向MRI造影剂的方法。
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公开(公告)号：US20080193547A1
公开(公告)日：2008-08-14
申请号：US12005643
申请日：2007-12-27
申请人： Janos Borbely , Magdolna Bodnar , Istvan Hajdu , John F. Hartmann
发明人： Janos Borbely , Magdolna Bodnar , Istvan Hajdu , John F. Hartmann
IPC分类号： A61K9/16 , A61K31/7088 , A61K31/519
CPC分类号： A61K31/519 , A61K9/5146 , A61K9/5161 , A61K31/7088 , A61K47/6929 , A61K47/6933 , A61K47/6939 , A61K49/12 , A61K49/146 , A61K49/1818 , A61K49/1878 , B82Y5/00
摘要： The present invention relates to biocompatible and biodegradable, stimuli sensitive, polymeric nanoparticles, which are formed by ion-ion interaction in aqueous media. Synthetic and biological macromolecules with ionizable functional groups are capable of forming nanoparticles whose size and surface properties are sensitive to environmental factors such as pH, temperature and salt concentration. Nanodevices made from these nanoparticles are designed for therapeutic applications included but not limited to use as drug carriers and/or used as contrast agents in MRI diagnosis and the like. The adjustable size of the nanodevices and their stimuli sensitivity allows specific delivery applications. Thus, these nanosystems are potential carrier tools for delivery of active ingredients such as drugs, as well as DNA, RNA, siRNA for cosmetics, pharmaceutical applications, etc.
摘要翻译： 本发明涉及通过在水介质中离子 - 离子相互作用而形成的生物相容性和可生物降解的刺激敏感的聚合物纳米颗粒。 具有可离子化官能团的合成和生物大分子能够形成尺寸和表面性质对环境因素如pH，温度和盐浓度敏感的纳米颗粒。 由这些纳米颗粒制成的纳米装置设计用于治疗应用，包括但不限于用作药物载体和/或用作MRI诊断等中的造影剂。 纳米器件的可调节尺寸及其刺激灵敏度允许特定的输送应用。 因此，这些纳米系统是用于递送活性成分如药物的潜在载体工具，以及用于化妆品的DNA，RNA，siRNA，药物应用等。
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公开(公告)号：US09352988B2
公开(公告)日：2016-05-31
申请号：US11601384
申请日：2006-11-17
IPC分类号： C02F1/68 , C02F101/20
CPC分类号： C02F1/683 , C02F2101/20 , Y10T428/2982
摘要： Methods are disclosed for preparing novel biodegradable nanoparticles based on complexation of poly-gamma-glutamic acid (γ-PGA) or its cross-linked derivatives with bivalent lead ions. The final products are stable in aqueous media at low pH, neutral and mild alkaline conditions. The size of the complexes depends on the pH, concentrations and the ratios of γ-PGA and lead ionsThe γ-PGA nanoparticles made from biodegradable biopolymers with high flocculating and heavy metal binding activity of the present invention may be used for various water treatment applications in aqueous media.
摘要翻译： 公开了基于聚-γ-谷氨酸（γ-PGA）或其交联衍生物与二价铅离子的络合制备新的可生物降解纳米颗粒的方法。 最终产物在低pH，中性和弱碱性条件下在水性介质中是稳定的。 复合物的大小取决于pH，浓度和γ-PGA和铅离子的比例由本发明的具有高絮凝和重金属结合活性的可生物降解的生物聚合物制成的γ-PGA纳米颗粒可用于各种水处理应用 在水性介质中。
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公开(公告)号：US07879818B2
公开(公告)日：2011-02-01
申请号：US11645094
申请日：2006-12-22
IPC分类号： A61K31/715
CPC分类号： A61K31/728 , A61K9/5161 , A61K9/5192 , C08B37/0072 , C08L5/08 , Y10S977/707 , Y10S977/788 , Y10S977/906
摘要： Methods are disclosed for preparing novel biodegradable cross-linked nanoparticles based on covalently cross-linking modifications of hyaluronic acid. The final products of the present invention are stable in aqueous media, and may be used as detergents and as additives for pharmaceutical compositions for drug delivery, DNA carrier system and other applications. The nanoparticles made from the biopolymers of the present invention may also be used in controlled release applications, super-absorbent materials as well as biomaterials like enzyme immobilization.
摘要翻译： 公开了基于透明质酸的共价交联修饰来制备新的可生物降解的交联纳米颗粒的方法。 本发明的最终产品在水性介质中是稳定的，并且可以用作洗涤剂和用作用于药物递送，DNA载体系统和其它应用的药物组合物的添加剂。 由本发明的生物聚合物制成的纳米颗粒也可用于控制释放应用，超吸收材料以及生物材料如酶固定。
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10.发明申请Reactive polymeric nanoparticles (RPNPS) for restoration materials in dentistry 审中-公开用于牙科修复材料的反应性聚合物纳米粒子（RPNPS）公开(公告)号：US20100144919A1
公开(公告)日：2010-06-10
申请号：US11998154
申请日：2007-11-28
IPC分类号： A61K6/083 , C08F220/06 , C08F4/30 , C08F4/04
CPC分类号： C08F2/22 , A61K6/083 , C08F2/06 , C08F212/08 , C08F220/06 , C08F222/1006 , C08F265/06 , C08F2222/1013 , C08F2222/1026 , C08L33/00 , C08L25/04
摘要： A method is disclosed in which modified and generic dental resins are combined as mixtures with reactive polymeric nanoparticles (RPNPs). Nanoparticles as additives clearly demonstrate that the RPNPs significantly influence the mechanical and shrinkage properties of the matrix and composites.
摘要翻译： 公开了一种方法，其中改性和通用牙科树脂与反应性聚合物纳米颗粒（RPNP）的混合物组合。 纳米颗粒作为添加剂清楚地表明，RPNP显着影响基体和复合材料的机械和收缩性能。
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