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公开(公告)号：US07740883B2
公开(公告)日：2010-06-22
申请号：US11091940
申请日：2005-03-28
申请人： Janos Borbely , Magdolna Bodnar
发明人： Janos Borbely , Magdolna Bodnar
IPC分类号： C08B37/08
CPC分类号： C08B37/003 , A61K9/5161 , A61K9/5192 , A61K47/36 , B01J13/14 , B82Y30/00
摘要： Methods are disclosed for preparing crosslinked core and core-shell nanoparticle polymers from chitosan. The final products of the present invention may be used as detergents and as additives for pharmaceutical composition and for drug delivery, and DNA carrier system. The nanoparticles made from biopolymers of the present invention may also be used in controlled release, superabsorbent materials and biomaterials like enzyme immobilization.
摘要翻译： 公开了从壳聚糖制备交联核心和核 - 壳纳米颗粒聚合物的方法。 本发明的最终产品可用作洗涤剂和用作药物组合物和药物递送的添加剂以及DNA载体体系。 由本发明的生物聚合物制成的纳米颗粒也可用于控制释放，超吸收材料和诸如酶固定的生物材料。
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公开(公告)号：US20080237135A1
公开(公告)日：2008-10-02
申请号：US11601384
申请日：2006-11-17
CPC分类号： C02F1/683 , C02F2101/20 , Y10T428/2982
摘要： Methods are disclosed for preparing novel biodegradable nanoparticles based on complexation of poly-gamma-glutamic acid (γ-PGA) or its cross-linked derivatives with bivalent lead ions. The final products are stable in aqueous media at low pH, neutral and mild alkaline conditions. The size of the complexes depends on the pH, concentrations and the ratios of γ-PGA and lead ionsThe γ-PGA nanoparticles made from biodegradable biopolymers with high flocculating and heavy metal binding activity of the present invention may be used for various water treatment applications in aqueous media.
摘要翻译： 公开了基于聚-γ-谷氨酸（γ-PGA）或其交联衍生物与二价铅离子的络合制备新的可生物降解纳米颗粒的方法。 最终产物在低pH，中性和弱碱性条件下在水性介质中是稳定的。 复合物的大小取决于pH，浓度和γ-PGA和铅离子的比例。本发明的具有高絮凝和重金属结合活性的可生物降解的生物聚合物制成的γ-PGA纳米颗粒可用于各种水处理应用 在水性介质中。
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公开(公告)号：US09352988B2
公开(公告)日：2016-05-31
申请号：US11601384
申请日：2006-11-17
IPC分类号： C02F1/68 , C02F101/20
CPC分类号： C02F1/683 , C02F2101/20 , Y10T428/2982
摘要： Methods are disclosed for preparing novel biodegradable nanoparticles based on complexation of poly-gamma-glutamic acid (γ-PGA) or its cross-linked derivatives with bivalent lead ions. The final products are stable in aqueous media at low pH, neutral and mild alkaline conditions. The size of the complexes depends on the pH, concentrations and the ratios of γ-PGA and lead ionsThe γ-PGA nanoparticles made from biodegradable biopolymers with high flocculating and heavy metal binding activity of the present invention may be used for various water treatment applications in aqueous media.
摘要翻译： 公开了基于聚-γ-谷氨酸（γ-PGA）或其交联衍生物与二价铅离子的络合制备新的可生物降解纳米颗粒的方法。 最终产物在低pH，中性和弱碱性条件下在水性介质中是稳定的。 复合物的大小取决于pH，浓度和γ-PGA和铅离子的比例由本发明的具有高絮凝和重金属结合活性的可生物降解的生物聚合物制成的γ-PGA纳米颗粒可用于各种水处理应用 在水性介质中。
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公开(公告)号：US07879818B2
公开(公告)日：2011-02-01
申请号：US11645094
申请日：2006-12-22
IPC分类号： A61K31/715
CPC分类号： A61K31/728 , A61K9/5161 , A61K9/5192 , C08B37/0072 , C08L5/08 , Y10S977/707 , Y10S977/788 , Y10S977/906
摘要： Methods are disclosed for preparing novel biodegradable cross-linked nanoparticles based on covalently cross-linking modifications of hyaluronic acid. The final products of the present invention are stable in aqueous media, and may be used as detergents and as additives for pharmaceutical compositions for drug delivery, DNA carrier system and other applications. The nanoparticles made from the biopolymers of the present invention may also be used in controlled release applications, super-absorbent materials as well as biomaterials like enzyme immobilization.
摘要翻译： 公开了基于透明质酸的共价交联修饰来制备新的可生物降解的交联纳米颗粒的方法。 本发明的最终产品在水性介质中是稳定的，并且可以用作洗涤剂和用作用于药物递送，DNA载体系统和其它应用的药物组合物的添加剂。 由本发明的生物聚合物制成的纳米颗粒也可用于控制释放应用，超吸收材料以及生物材料如酶固定。
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公开(公告)号：US07976825B2
公开(公告)日：2011-07-12
申请号：US12315951
申请日：2008-12-08
申请人： Janos Borbely , Magdolna Bodnar , John F Hartmann , Istvan Hajdu , Jozsef Kollar , Gyorgy Vamosi
发明人： Janos Borbely , Magdolna Bodnar , John F Hartmann , Istvan Hajdu , Jozsef Kollar , Gyorgy Vamosi
CPC分类号： A61K31/519 , A61K31/7088 , A61K49/1824 , B82Y5/00 , Y10S977/773 , Y10S977/93
摘要： Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular relaxivity of carriers. The synthesis of biomolecular based nanodevices for targeted delivery of MRI contrast agents are described. Nanoparticles (NP) have been constructed by self-assembling of chitosan (CHIT) as polycation and poly-gamma glutamic acids (PGA) as polyanion. NP's are capable of Gd-ion uptake forming a particle with suitable molecular relaxivity. Folic acid (FA) is linked to the NP's to produce NP-FA bioconjugates that can be used for targeted in vitro delivery to a human cancer cell line.
摘要翻译： 描述了用于磁共振成像的大分子造影剂。 生物分子及其修饰的衍生物与顺磁离子形成稳定的络合物，从而增加载体的分子弛豫性。 描述了用于靶向递送MRI造影剂的基于生物分子的纳米装置的合成。 纳米颗粒（NP）已经通过壳聚糖（CHIT）作为聚阳离子和聚-γ谷氨酸（PGA）作为聚阴离子自组装而构建。 NP能够进行Gd离子吸收，形成具有合适分子弛豫性的颗粒。 叶酸（FA）与NP连接以产生可用于靶向体外递送至人癌细胞系的NP-FA生物缀合物。
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公开(公告)号：US20140099266A1
公开(公告)日：2014-04-10
申请号：US13944742
申请日：2013-07-17
IPC分类号： A61K49/18
CPC分类号： A61K49/1881 , A61K49/1833 , A61K49/1863 , A61K49/1872
摘要： Targeting contrast agent for magnetic resonance imaging (MRI). In preferred embodiments, self-assembled polyelectrolytes coated superparamagnetic iron oxide contrast agent particles are provided, which are labeled with targeting moieties, afforded enhanced relaxivity, improved signal-to-noise and targeting ability. Accordingly, the invention relates to a stable targeting contrast nanosystem applicable for magnetic resonance imaging (MRI) having at least one nanoparticle polyelectrolyte polyanion; a targeting agent conjugated to the biopolymer; and a superparamagnetic ligand. In another embodiment the nanosystem according to the invention has at least two biocompatible and biodegradable nanoparticle polyelectrolyte biopolymer. Particularly, the superparamagnetic iron oxide particles are coated by a polyelectrolyte biopolymer and this system self-assembles with the other biopolymer to produce stable nanosystem for magnetic resonance imaging. Targeting moieties are conjugated to a biopolymer or to the self-assembled biopolymers to realize a targeted delivery of contrast agent. Methods for making these targeting MRI contrast agents are also provided.
摘要翻译： 用于磁共振成像（MRI）的靶向造影剂。 在优选的实施方案中，提供了自组装聚电解质涂覆的超顺磁性氧化铁对比剂颗粒，其被靶向部分标记，提供增强的弛豫度，改进的信噪比和靶向能力。 因此，本发明涉及适用于具有至少一种纳米颗粒聚电解质聚阴离子的磁共振成像（MRI）的稳定靶向对比纳米系统; 与生物聚合物缀合的靶向剂; 和超顺磁配体。 在另一个实施方案中，根据本发明的纳米系统具有至少两种生物相容性和可生物降解的纳米粒子聚电解质生物聚合物。 特别地，超顺磁性氧化铁颗粒由聚电解质生物聚合物涂覆，并且该系统与其他生物聚合物自组装，以产生用于磁共振成像的稳定的纳米系统。 靶向部分与生物聚合物或自组装生物聚合物缀合以实现造影剂的靶向递送。 还提供了制备这些靶向MRI造影剂的方法。
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公开(公告)号：US20080193547A1
公开(公告)日：2008-08-14
申请号：US12005643
申请日：2007-12-27
申请人： Janos Borbely , Magdolna Bodnar , Istvan Hajdu , John F. Hartmann
发明人： Janos Borbely , Magdolna Bodnar , Istvan Hajdu , John F. Hartmann
IPC分类号： A61K9/16 , A61K31/7088 , A61K31/519
CPC分类号： A61K31/519 , A61K9/5146 , A61K9/5161 , A61K31/7088 , A61K47/6929 , A61K47/6933 , A61K47/6939 , A61K49/12 , A61K49/146 , A61K49/1818 , A61K49/1878 , B82Y5/00
摘要： The present invention relates to biocompatible and biodegradable, stimuli sensitive, polymeric nanoparticles, which are formed by ion-ion interaction in aqueous media. Synthetic and biological macromolecules with ionizable functional groups are capable of forming nanoparticles whose size and surface properties are sensitive to environmental factors such as pH, temperature and salt concentration. Nanodevices made from these nanoparticles are designed for therapeutic applications included but not limited to use as drug carriers and/or used as contrast agents in MRI diagnosis and the like. The adjustable size of the nanodevices and their stimuli sensitivity allows specific delivery applications. Thus, these nanosystems are potential carrier tools for delivery of active ingredients such as drugs, as well as DNA, RNA, siRNA for cosmetics, pharmaceutical applications, etc.
摘要翻译： 本发明涉及通过在水介质中离子 - 离子相互作用而形成的生物相容性和可生物降解的刺激敏感的聚合物纳米颗粒。 具有可离子化官能团的合成和生物大分子能够形成尺寸和表面性质对环境因素如pH，温度和盐浓度敏感的纳米颗粒。 由这些纳米颗粒制成的纳米装置设计用于治疗应用，包括但不限于用作药物载体和/或用作MRI诊断等中的造影剂。 纳米器件的可调节尺寸及其刺激灵敏度允许特定的输送应用。 因此，这些纳米系统是用于递送活性成分如药物的潜在载体工具，以及用于化妆品的DNA，RNA，siRNA，药物应用等。
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公开(公告)号：US20080160096A1
公开(公告)日：2008-07-03
申请号：US11881831
申请日：2007-07-27
申请人： Janos Berbely , Magdolna Bodnar , Istvan Hajdu , John F. Hartmann , Zsolt Keresztessy , Laszlo Nagy , Gyorgy Vamosi
发明人： Janos Berbely , Magdolna Bodnar , Istvan Hajdu , John F. Hartmann , Zsolt Keresztessy , Laszlo Nagy , Gyorgy Vamosi
IPC分类号： A61K9/50
CPC分类号： A61K9/5138 , A61K9/5015 , A61K9/5026 , A61K9/5036 , A61K9/5146 , A61K9/5161 , A61K9/5192 , C12N15/87
摘要： The present invention relates to biocompatible and biodegradable stimuli-sensitive polymeric nanoparticles, which were formed by ion-ion interaction in aqueous media. Synthetic and biological macromolecules with ionizable functional groups are capable of forming nanoparticles whose size and surface properties are sensitive to environmental influences such as pH, temperature and salt concentration. Nanodevices are designed for therapeutic applications as drug and nucleic acid carriers, and/or for MRI diagnosis as contrast agents. These nanodevices are designed for therapeutic applications as targeted drug carriers. Additionally, they can be used as contrast agents for MRI diagnosis. These nanosystems are also potential carriers for delivery of active ingredients as DNA, RNA, short interfering RNA (siRNA), antisense oligonucleotides (AS-ON), and triple helix forming oligonucleotides (TFO) etc. for pharmaceutical applications. Their adjustable size offers yet another advantage.
摘要翻译： 本发明涉及生物相容性和生物可降解的刺激性敏感的聚合物纳米粒子，其通过在水性介质中的离子 - 离子相互作用而形成。 具有可离子化官能团的合成和生物大分子能够形成尺寸和表面性质对pH，温度和盐浓度等环境影响敏感的纳米颗粒。 纳米设备设计用作药物和核酸载体的治疗应用，和/或作为造影剂的MRI诊断。 这些纳米设备被设计用作靶向药物载体的治疗应用。 此外，它们可以用作MRI诊断的造影剂。 这些纳米系统也是作为药物应用的DNA，RNA，短干扰RNA（siRNA），反义寡核苷酸（AS-ON）和三螺旋形成寡核苷酸（TFO）等递送活性成分的潜在载体。 它们的可调节尺寸提供了另一个优点。
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公开(公告)号：US20090180966A1
公开(公告)日：2009-07-16
申请号：US12315951
申请日：2008-12-08
申请人： Janos Borbely , Magdolna Bodnar , John F. Hartmann , Istvan Hajdu , Jozsef Kollar , Gyorgy Vamosi
发明人： Janos Borbely , Magdolna Bodnar , John F. Hartmann , Istvan Hajdu , Jozsef Kollar , Gyorgy Vamosi
CPC分类号： A61K31/519 , A61K31/7088 , A61K49/1824 , B82Y5/00 , Y10S977/773 , Y10S977/93
摘要： Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular relaxivity of carriers. The synthesis of biomolecular based nanodevices for targeted delivery of MRI contrast agents are described. Nanoparticles (NP) have been constructed by self-assembling of chitosan (CHIT) as polycation and poly-gamma glutamic acids (PGA) as polyanion. NP's are capable of Gd-ion uptake forming a particle with suitable molecular relaxivity. Folic acid (FA) is linked to the NP's to produce NP-FA bioconjugates that can be used for targeted in vitro delivery to a human cancer cell line.
摘要翻译： 描述了用于磁共振成像的大分子造影剂。 生物分子及其修饰的衍生物与顺磁离子形成稳定的络合物，从而增加载体的分子弛豫性。 描述了用于靶向递送MRI造影剂的基于生物分子的纳米装置的合成。 纳米颗粒（NP）已经通过壳聚糖（CHIT）作为聚阳离子和聚-γ谷氨酸（PGA）作为聚阴离子自组装而构建。 NP能够进行Gd离子吸收，形成具有合适分子弛豫性的颗粒。 叶酸（FA）与NP连接以产生可用于靶向体外递送至人癌细胞系的NP-FA生物缀合物。
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公开(公告)号：US20050226938A1
公开(公告)日：2005-10-13
申请号：US11091940
申请日：2005-03-28
申请人： Janos Borbely , Magdolna Bodnar
发明人： Janos Borbely , Magdolna Bodnar
CPC分类号： C08B37/003 , A61K9/5161 , A61K9/5192 , A61K47/36 , B01J13/14 , B82Y30/00
摘要： Methods are disclosed for preparing crosslinked core and core-shell nanoparticle polymers from chitosan. The final products of the present invention may be used as detergents and as additives for pharmaceutical composition and for drug delivery, and DNA carrier system. The nanoparticles made from biopolymers of the present invention may also be used in controlled release, superabsorbent materials and biomaterials like enzyme immobilization.
摘要翻译： 公开了从壳聚糖制备交联核心和核 - 壳纳米颗粒聚合物的方法。 本发明的最终产品可用作洗涤剂和用作药物组合物和药物递送的添加剂以及DNA载体体系。 由本发明的生物聚合物制成的纳米颗粒也可用于控制释放，超吸收材料和诸如酶固定的生物材料。
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