公开(公告)号：US20210040483A1

公开(公告)日：2021-02-11

申请号：US17063080

申请日：2020-10-05

Applicant: Janssen Biopharma, Inc.

Inventor： Sergei GRYAZNOV ,  Leonid BEIGELMAN ,  Antitsa Dimitrova STOYCHEVA ,  Saul MARTINEZ MONTERO ,  Jin HONG ,  Rajendra K. PANDEY ,  Vivek Kumar RAJWANSHI ,  Lakshmipathi PANDARINATHAN ,  Yi JIN ,  Bharat BARAL

IPC: C12N15/113 ,  A61K31/7125 ,  A61P31/20 ,  A61K31/712 ,  C07H21/02 ,  A61K47/54 ,  C12N15/11

Abstract: Modified oligonucleotides comprising modifications at the 2′ and/or 3′ position(s) along with methods of making and use, e.g., against HBV are disclosed.