公开(公告)号：US20200270611A1

公开(公告)日：2020-08-27

申请号：US16647377

申请日：2018-09-14

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei GRYAZNOV ,  Jin HONG ,  Rajendra K. PANDEY ,  Vivek Kumar RAJWANSHI

IPC: C12N15/113 ,  C07H15/26 ,  C07H15/18 ,  C07H15/04

Abstract: Modified oligonucleotides comprising a GalNAc moiety of the present disclosure along with methods of making and use, e.g., against HBV are disclosed.

公开(公告)号：US20240309040A1

公开(公告)日：2024-09-19

申请号：US18672651

申请日：2024-05-23

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei GRYAZNOV ,  Jin HONG ,  Vivek Kumar RAJWANSHI ,  Leonid BEIGELMAN

IPC: C07H19/10 ,  C07H1/00 ,  C07H19/20

CPC classification number: C07H19/10 ,  C07H1/00 ,  C07H19/20

Abstract: The present disclosure relates to compounds and compositions containing 5′-phosphoramidite nucleoside monomers, and methods of making and use.

公开(公告)号：US20210040483A1

公开(公告)日：2021-02-11

申请号：US17063080

申请日：2020-10-05

Applicant: Janssen Biopharma, Inc.

Inventor： Sergei GRYAZNOV ,  Leonid BEIGELMAN ,  Antitsa Dimitrova STOYCHEVA ,  Saul MARTINEZ MONTERO ,  Jin HONG ,  Rajendra K. PANDEY ,  Vivek Kumar RAJWANSHI ,  Lakshmipathi PANDARINATHAN ,  Yi JIN ,  Bharat BARAL

IPC: C12N15/113 ,  A61K31/7125 ,  A61P31/20 ,  A61K31/712 ,  C07H21/02 ,  A61K47/54 ,  C12N15/11

Abstract: Modified oligonucleotides comprising modifications at the 2′ and/or 3′ position(s) along with methods of making and use, e.g., against HBV are disclosed.

公开(公告)号：US20200255468A1

公开(公告)日：2020-08-13

申请号：US16647236

申请日：2018-09-14

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei GRYAZNOV ,  Jin HONG ,  Vivek Kumar RAJWANSHI

IPC: C07H19/10 ,  C07H19/20 ,  C07H1/00

Abstract: The present disclosure relates to compounds and compositions containing 5′-phosphoramidite nucleoside monomers of formulae (I) and (II), and methods of making and use, wherein the substituents are as defined in the appended claims.