公开(公告)号：US12077757B2

公开(公告)日：2024-09-03

申请号：US17063080

申请日：2020-10-05

Applicant: Janssen Biopharma, Inc.

Inventor： Sergei Gryaznov ,  Leonid Beigelman ,  Antitsa Dimitrova Stoycheva ,  Saul Martinez Montero ,  Jin Hong ,  Rajendra K. Pandey ,  Vivek Kumar Rajwanshi ,  Lakshmipathi Pandarinathan ,  Yi Jin ,  Bharat Baral

IPC: C07H21/02 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/54 ,  A61P31/20 ,  C12N15/11 ,  C12N15/113

CPC classification number: C12N15/1131 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/549 ,  A61P31/20 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/314 ,  C12N2310/3145 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/344 ,  C12N2310/351 ,  C12N2320/32 ,  C12N2310/321 ,  C12N2310/3525

Abstract: Modified oligonucleotides comprising modifications at the 2′ and/or 3′ position(s) along with methods of making and use, e.g., against HBV are disclosed.

公开(公告)号：US20230365608A1

公开(公告)日：2023-11-16

申请号：US17426974

申请日：2020-01-30

Applicant: Janssen BioPharma, Inc.

Inventor： Leonid BEIGELMAN ,  Guangyi WANG ,  Natalia DYATKINA

IPC: C07H7/06 ,  C07H15/04 ,  A61P31/16

CPC classification number: C07H7/06 ,  C07H15/04 ,  A61P31/16

Abstract: Disclosed herein are nucleoside compounds and derivatives thereof, pharmaceutical compositions containing same, and their methods of synthesis. The compounds are useful in treating orthomyxovirus infections, such as influenza infections.

公开(公告)号：US20220363640A1

公开(公告)日：2022-11-17

申请号：US17208964

申请日：2021-03-22

Applicant: Janssen BioPharma, Inc.

Inventor： Guangyi WANG ,  Leonid BEIGELMAN ,  Anh TRUONG ,  Carmela NAPOLITANO ,  Daniele ANDREOTTI ,  Haiying HE ,  Karin Ann STEIN

IPC: C07D213/40 ,  C07D409/04 ,  C07D495/14 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C07D239/34 ,  C07D471/04 ,  C07D213/65 ,  C07D401/12 ,  C07D491/048 ,  C07D233/64 ,  C07D409/14 ,  C07D417/06 ,  C07D413/12 ,  C07D413/06 ,  C07D401/06 ,  C07D405/12 ,  C07D417/12 ,  C07D207/273 ,  C07D491/052 ,  A61K31/4436 ,  A61K31/4418 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/4365 ,  A61K31/422 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/505 ,  A61K31/437 ,  A61K45/06 ,  A61K31/4355 ,  A61K31/444 ,  A61K31/4709

Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

公开(公告)号：US20210196831A1

公开(公告)日：2021-07-01

申请号：US17142192

申请日：2021-01-05

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei GRYAZNOV ,  Leonid BEIGELMAN ,  Theodore YUN

IPC: A61K47/54 ,  A61P31/20 ,  A61P35/00 ,  A61K39/39 ,  A61K47/22 ,  A61K47/26 ,  C12Q1/6876 ,  A61K47/14 ,  A61K9/00 ,  A61K31/7088

Abstract: Oligodeoxynucleotide-based immunostimulatory Toll-Like Receptor 9 (TLR9) agonists are described. Also described are compositions comprising the TLR9 agonists, methods of making the TLR9 agonists, and methods of using the TLR9 agonists to treat immune diseases, disorders or conditions, such as viral infections or cancer.

公开(公告)号：US11021444B2

公开(公告)日：2021-06-01

申请号：US16165865

申请日：2018-10-19

Applicant: Janssen BioPharma, Inc.

Inventor： Guangyi Wang ,  Leonid Beigelman ,  Anh Truong ,  Carmela Napolitano ,  Daniele Andreotti ,  Haiying He ,  Karin Ann Stein

IPC: C07D213/40 ,  A61K45/06 ,  A61K31/4355 ,  A61K31/505 ,  A61K31/427 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/4178 ,  A61K31/4418 ,  A61K31/4436 ,  C07D491/052 ,  C07D207/273 ,  C07D417/12 ,  C07D405/12 ,  C07D401/06 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D409/14 ,  C07D233/64 ,  C07D491/048 ,  C07D401/12 ,  C07D213/65 ,  C07D471/04 ,  C07D239/34 ,  C07D417/04 ,  C07D413/04 ,  C07D401/04 ,  C07D495/14 ,  C07D409/04 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4709

Abstract: Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

公开(公告)号：US20210106604A1

公开(公告)日：2021-04-15

申请号：US17001512

申请日：2020-08-24

Applicant: Janssen BioPharma, Inc.

Inventor： Lawrence M. Blatt ,  Leonid Beigelman ,  Natalia Dyatkina ,  Julian Alexander Symons ,  David Bernard Smith

IPC: A61K31/7068 ,  A61K31/708 ,  A61K31/7072 ,  A61K31/7076

Abstract: Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.

公开(公告)号：US10793859B2

公开(公告)日：2020-10-06

申请号：US15705137

申请日：2017-09-14

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei Gryaznov ,  Leonid Beigelman ,  Antitsa Dimitrova Stoycheva ,  Saul Martinez Montero ,  Jin Hong ,  Rajendra K. Pandey ,  Vivek Kumar Rajwanshi ,  Lakshmipathi Pandarinathan ,  Yi Jin ,  Bharat Baral

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12N15/11 ,  A61K31/712 ,  A61K47/54 ,  A61P31/20 ,  A61K31/7125

Abstract: Modified oligonucleotides comprising modifications at the 2′ and/or 3′ positions(s) along with methods of making and use, e.g., against HBV are disclosed.

公开(公告)号：US20200255468A1

公开(公告)日：2020-08-13

申请号：US16647236

申请日：2018-09-14

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei GRYAZNOV ,  Jin HONG ,  Vivek Kumar RAJWANSHI

IPC: C07H19/10 ,  C07H19/20 ,  C07H1/00

Abstract: The present disclosure relates to compounds and compositions containing 5′-phosphoramidite nucleoside monomers of formulae (I) and (II), and methods of making and use, wherein the substituents are as defined in the appended claims.

公开(公告)号：US20200030328A1

公开(公告)日：2020-01-30

申请号：US16537396

申请日：2019-08-09

Applicant: Janssen BioPharma, Inc.

Inventor： Robert Than Hendricks ,  Leonid Beigelman ,  David Bernard Smith ,  Antitsa Dimitrova Stoycheva

IPC: A61K31/5025 ,  C07D487/04 ,  A61K31/13 ,  A61K31/196 ,  A61K31/215 ,  A61K31/351 ,  A61K31/4965 ,  A61K31/5377 ,  A61K31/7056 ,  A61K38/21 ,  C07B59/00

Abstract: Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.

公开(公告)号：US20190381081A1

公开(公告)日：2019-12-19

申请号：US16449164

申请日：2019-06-21

Applicant: Janssen BioPharma, Inc.

Inventor： Guangyi WANG ,  David Bernard SMITH ,  Leonid BEIGELMAN ,  Jerome DEVAL ,  Marija PRHAVC

IPC: A61K31/708 ,  C07H19/20 ,  C07H19/06 ,  C07H19/16 ,  C07H19/10 ,  C07H19/12 ,  C07H19/207 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/706

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof.