公开(公告)号：US20220064284A1

公开(公告)日：2022-03-03

申请号：US17376874

申请日：2021-07-15

Applicant: Janssen Biotech, Inc.

Inventor： Ellen CHI ,  Wilson EDWARDS ,  Matt HUSOVSKY ,  Ann LACOMBE ,  Christian MARTINEZ ,  H. Mimi ZHOU ,  John T. LEE

IPC: C07K16/28 ,  G01N33/50

Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a GP5B83 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include GP5B83.

公开(公告)号：US20240218083A1

公开(公告)日：2024-07-04

申请号：US18555924

申请日：2022-04-18

Applicant: Janssen Biotech, Inc.

Inventor： Sanjaya SINGH ,  Ellen CHI ,  Martin CASE ,  Hong Mimi ZHOU ,  Linus HYUN ,  Jennifer FURMAN ,  Ann LACOMBE

IPC: C07K16/46 ,  A61K39/00 ,  C40B40/10

CPC classification number: C07K16/468 ,  C40B40/10 ,  A61K2039/505 ,  C07K2317/515 ,  C07K2317/522 ,  C07K2317/55

Abstract: A binding molecule comprising (i) a first polypeptide comprising a heavy chain variable region (VH) and a region derived from the first constant region of an antibody heavy chain (CH1), and (ii) a second polypeptide comprising a light chain variable region (VL) and a region derived from the constant region of an antibody light chain (CL), wherein the region derived from the CH1 region and/or the region derived from the CL region comprises one or more antigen binding loop(s).

公开(公告)号：US20220064334A1

公开(公告)日：2022-03-03

申请号：US17376830

申请日：2021-07-15

Applicant: Janssen Biotech, Inc.

Inventor： Zemeda AINEKULU ,  Qiang CHEN ,  Ellen CHI ,  Wilson EDWARDS ,  Matt HUSOVSKY ,  Ann LACOMBE ,  Quynh NGUYEN ,  Paul H. KIM ,  H. Mimi ZHOU ,  John T. LEE

IPC: C07K16/42 ,  G01N33/68 ,  C07K1/22

Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a KL2B413 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include KL2B413.