公开(公告)号：US20220064284A1

公开(公告)日：2022-03-03

申请号：US17376874

申请日：2021-07-15

申请人： Janssen Biotech, Inc.

发明人： Ellen CHI ,  Wilson EDWARDS ,  Matt HUSOVSKY ,  Ann LACOMBE ,  Christian MARTINEZ ,  H. Mimi ZHOU ,  John T. LEE

IPC分类号： C07K16/28 ,  G01N33/50

摘要： In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a GP5B83 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include GP5B83.

公开(公告)号：US20220064254A1

公开(公告)日：2022-03-03

申请号：US16936719

申请日：2020-07-23

申请人： Janssen Biotech, Inc.

发明人： Raymond BRITTINGHAM ,  Rajkumar GANESAN ,  Sherry LA PORTE ,  John T. LEE ,  Jinquan LUO ,  Theresa MCDEVITT ,  Fei SHEN ,  Sanjaya SINGH ,  Degang SONG ,  Sathyadevi VENKATARAMANI ,  Fang YI ,  Yonghong ZHAO

IPC分类号： C07K14/725 ,  A61K35/17 ,  C07K16/40 ,  C07K14/705

摘要： The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：US20220064334A1

公开(公告)日：2022-03-03

申请号：US17376830

申请日：2021-07-15

申请人： Janssen Biotech, Inc.

发明人： Zemeda AINEKULU ,  Qiang CHEN ,  Ellen CHI ,  Wilson EDWARDS ,  Matt HUSOVSKY ,  Ann LACOMBE ,  Quynh NGUYEN ,  Paul H. KIM ,  H. Mimi ZHOU ,  John T. LEE

IPC分类号： C07K16/42 ,  G01N33/68 ,  C07K1/22

摘要： In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a KL2B413 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include KL2B413.