公开(公告)号：US20200148736A1

公开(公告)日：2020-05-14

申请号：US16746052

申请日：2020-01-17

Applicant: Janssen Biotech, Inc.

Inventor： Thomas Rutkoski ,  Alexey Teplyakov ,  Nicole Wunderler

IPC: C07K14/535 ,  A61K45/06 ,  A61K38/19

Abstract: GM-CSF variants, polynucleotides encoding them, and methods of making and using the foregoing are useful in treatment of immune-related disorders, such as inflammatory bowel disease (IBD).

公开(公告)号：US10562948B2

公开(公告)日：2020-02-18

申请号：US15616216

申请日：2017-06-07

Applicant: Janssen Biotech, Inc.

Inventor： Thomas Rutkoski ,  Alexey Teplyakov ,  Nicole Wunderler

IPC: C07K14/535 ,  A61K38/19 ,  A61K45/06

Abstract: GM-CSF variants, polynucleotides encoding them, and methods of making and using the foregoing are useful in treatment of immune-related disorders, such as inflammatory bowel disease (IBD).

公开(公告)号：US11833190B2

公开(公告)日：2023-12-05

申请号：US17153229

申请日：2021-01-20

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs ,  Karyn O'Neil ,  Thomas Rutkoski

IPC: C07K14/78 ,  A61K38/39 ,  G01N33/68 ,  A61K47/54 ,  C07K16/18 ,  C07K16/40 ,  A61K39/00

CPC classification number: A61K38/39 ,  A61K47/549 ,  C07K14/78 ,  C07K16/18 ,  C07K16/40 ,  G01N33/68 ,  A61K2039/505 ,  C07K2317/94 ,  C07K2318/20 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/70 ,  G01N2333/765 ,  G01N2333/78

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.

公开(公告)号：US11208450B2

公开(公告)日：2021-12-28

申请号：US16746052

申请日：2020-01-17

Applicant: Janssen Biotech, Inc.

Inventor： Thomas Rutkoski ,  Alexey Teplyakov ,  Nicole Wunderler

IPC: C07K14/535 ,  A61K38/19 ,  C12N15/00 ,  C12N5/00 ,  A61K45/06

Abstract: GM-CSF variants, polynucleotides encoding them, and methods of making and using the foregoing are useful in treatment of immune-related disorders, such as inflammatory bowel disease (IBD).

公开(公告)号：US20240100129A1

公开(公告)日：2024-03-28

申请号：US18496397

申请日：2023-10-27

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs ,  Karyn O'Neil ,  Thomas Rutkoski

IPC: A61K38/39 ,  A61K47/54 ,  C07K14/78 ,  C07K16/18 ,  C07K16/40 ,  G01N33/68

CPC classification number: A61K38/39 ,  A61K47/549 ,  C07K14/78 ,  C07K16/18 ,  C07K16/40 ,  G01N33/68 ,  A61K2039/505 ,  C07K2317/94

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.

公开(公告)号：US20210228688A1

公开(公告)日：2021-07-29

申请号：US17153229

申请日：2021-01-20

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs ,  Karyn O'Neil ,  Thomas Rutkoski

IPC: A61K38/39 ,  A61K47/54 ,  C07K14/78 ,  C07K16/18 ,  C07K16/40

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.

公开(公告)号：US10925932B2

公开(公告)日：2021-02-23

申请号：US15611296

申请日：2017-06-01

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs ,  Karyn O'Neil ,  Thomas Rutkoski

IPC: C07K14/78 ,  A61K38/39 ,  A61K47/54 ,  C07K16/18 ,  C07K16/40 ,  A61K39/00

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.

公开(公告)号：US20170355742A1

公开(公告)日：2017-12-14

申请号：US15616216

申请日：2017-06-07

Applicant: Janssen Biotech, Inc.

Inventor： Thomas Rutkoski ,  Alexey Teplyakov ,  Nicole Wunderler

IPC: C07K14/535 ,  A61K45/06 ,  A61K38/19

Abstract: GM-CSF variants, polynucleotides encoding them, and methods of making and using the foregoing are useful in treatment of immune-related disorders, such as inflammatory bowel disease (IBD).

公开(公告)号：US20170348397A1

公开(公告)日：2017-12-07

申请号：US15611296

申请日：2017-06-01

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs ,  Karyn O'Neil ,  Thomas Rutkoski

IPC: A61K38/39 ,  C07K16/40 ,  C07K14/78 ,  C07K16/18

CPC classification number: A61K38/39 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/78 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/94 ,  C07K2318/20 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/70

Abstract: Fibronectin type III domains (FN3) that specifically bind to serum albumin, related polynucleotides capable of encoding serum albumin-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, detectably labeled FN3 domains and FN3 domains fused to a heterologous moiety are useful in extending the half-life of molecules in diagnostic and therapeutic applications.