公开(公告)号：US20240383954A1

公开(公告)日：2024-11-21

申请号：US18657493

申请日：2024-05-07

Applicant: Janssen Biotech, Inc. ,  Protagonist Therapeutics, Inc.

Inventor： Chengzao SUN ,  Brian Troy FREDERICK ,  Sandeep SOMANI ,  Ashok BHANDARI ,  Raymond PATCH ,  Stephanie BARROS ,  Raffaele INGENITO ,  Roberto COSTANTE ,  Danila BRANCA ,  Elisabetta BIANCHI

IPC: C07K14/47 ,  A61K38/00 ,  A61K47/60

Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.

公开(公告)号：US20240150405A1

公开(公告)日：2024-05-09

申请号：US18492612

申请日：2023-10-23

Applicant: Janssen Biotech, Inc. ,  Protagonist Therapeutics, Inc.

Inventor： Chengzao SUN ,  Brian Troy FREDERICK ,  Sandeep SOMANI ,  Gregory Thomas BOURNE ,  Raymond PATCH ,  Ashok BHANDARI ,  Raffaele INGENITO ,  Roberto COSTANTE ,  Danila BRANCA ,  Elisabetta BIANCHI

IPC: C07K7/64

CPC classification number: C07K7/64 ,  A61K38/00

Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.

公开(公告)号：US20240209024A1

公开(公告)日：2024-06-27

申请号：US18366558

申请日：2023-08-07

Applicant: Protagonist Therapeutics, Inc.

Inventor： Gregory Thomas BOURNE ,  Ashok BHANDARI ,  Brian Troy FREDERICK ,  Jie ZHANG ,  Adam STEPHENSON ,  Mark Leslie SMYTHE ,  Roopa TARANATH ,  David Y. LIU

IPC: C07K7/08 ,  A61K9/00 ,  A61K38/00

CPC classification number: C07K7/08 ,  A61K9/0053 ,  A61K38/00

Abstract: The present invention provides hepcidin analogues with improved in vivo half lives, and related pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20170313754A1

公开(公告)日：2017-11-02

申请号：US15321124

申请日：2015-06-29

Applicant: PROTAGONIST THERAPEUTICS ,INC.

Inventor： Gregory Thomas BOURNE ,  Mark Leslie SMYTHE ,  Brian Troy FREDERICK ,  Simone VINK

IPC: C07K14/575 ,  A61K38/00

CPC classification number: C07K14/575 ,  A61K38/00

Abstract: The present invention provides novel hepcidin analogues, and related methods of using these hepcidin analogues to treat or prevent a variety of diseases and disorders, including iron overload diseases such as hereditary hemochromatosis, iron-loading anemias, and other conditions and disorders described herein.

公开(公告)号：US20230129095A1

公开(公告)日：2023-04-27

申请号：US17792594

申请日：2021-01-14

Applicant: Protagonist Therapeutics, Inc.

Inventor： Ashok BHANDARI ,  Brian Troy FREDERICK ,  Tran Trung TRAN ,  Gregory Thomas BOURNE

IPC: C07K7/08 ,  A61P1/00

Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.

公开(公告)号：US20190300590A1

公开(公告)日：2019-10-03

申请号：US15745371

申请日：2016-07-15

Applicant: Protagonist Therapeutics, Inc.

Inventor： Ashok BHANDARI ,  Gregory BOURNE ,  Xiaoli CHENG ,  Brian Troy FREDERICK ,  Jie ZHANG ,  Dinesh V. PATEL ,  David LIU

IPC: C07K14/47 ,  A61P1/04

Abstract: The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.

公开(公告)号：US20240209026A1

公开(公告)日：2024-06-27

申请号：US18501864

申请日：2023-11-03

Applicant: Protagonist Therapeutics, Inc.

Inventor： Ashok BHANDARI ,  Dinesh V. PATEL ,  Genet ZEMEDE ,  Brian Troy FREDERICK ,  Larry C. MATTHEAKIS ,  David LIU

IPC: C07K7/56 ,  A61K38/00 ,  A61K38/12 ,  A61K47/54 ,  A61K47/60 ,  A61K47/64 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705

CPC classification number: C07K7/56 ,  A61K38/12 ,  A61K47/54 ,  A61K47/545 ,  A61K47/60 ,  A61K47/64 ,  C07K7/06 ,  C07K7/08 ,  C07K14/70546 ,  A61K38/00

Abstract: The invention relates to thioether monomer and dimer peptide molecules which inhibit binding of a4β7 to the mucosal addressing cell adhesion molecule (MAdCAM) in vivo.

公开(公告)号：US20240174726A1

公开(公告)日：2024-05-30

申请号：US18477490

申请日：2023-09-28

Applicant: Protagonist Therapeutics, Inc.

Inventor： Mark Leslie SMYTHE ,  Gregory Thomas BOURNE ,  Simone VINK ,  Brian Troy FREDERICK ,  Praveen MADALA ,  Anne Pernille TOFTENG SHELTON ,  Jacob Ulrik FOG

IPC: C07K14/575

CPC classification number: C07K14/575 ,  A61K38/00

Abstract: The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.

公开(公告)号：US20220348626A1

公开(公告)日：2022-11-03

申请号：US17099308

申请日：2020-11-16

Applicant: PROTAGONIST THERAPEUTICS, INC.

Inventor： Mark Leslie SMYTHE ,  Gregory Thomas BOURNE ,  Simone VINK ,  Brian Troy FREDERICK ,  Praveen MADALA ,  Anne Pernille TOFTENG SHELTON ,  Jacob Ulrik FOG

IPC: C07K14/575

Abstract: The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.

公开(公告)号：US20240199700A1

公开(公告)日：2024-06-20

申请号：US18527006

申请日：2023-12-01

Applicant: Protagonist Therapeutics, Inc.

Inventor： Ashok BHANDARI ,  Gregory Thomas BOURNE ,  Xiaoli CHENG ,  Brian Troy FREDERICK ,  Jie ZHANG ,  Dinesh V. PATEL ,  David LIU

IPC: C07K7/08 ,  A61K38/00 ,  C07K7/02 ,  C07K7/50 ,  C07K7/64 ,  C07K14/54

CPC classification number: C07K7/08 ,  C07K7/02 ,  C07K7/50 ,  C07K7/64 ,  C07K14/54 ,  A61K38/00 ,  G01N2800/065

Abstract: Peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease, are disclosed.