公开(公告)号：US20230142285A1

公开(公告)日：2023-05-11

申请号：US17604818

申请日：2020-12-17

申请人： Janssen Pharmaceutica NV

发明人： Wei CAI ,  Xuedong DAI ,  Oliver Alexis Georges QUEROLLE ,  Johannes Wilhelmus John F. THURING ,  Yingtao LIU ,  Lianzhu LIU ,  Yanping XU ,  Liqiang FU ,  Ming LI ,  Lichao FANG ,  Xianguin DENG ,  Qiwu ZHAO ,  Kangying LI ,  Alicia Tee Fuay NG ,  Nicolas Freddy J. DARVILLE ,  Edward CLEATOR ,  Gregor Thomas URBANIETZ ,  William Marc MATON ,  Vineet PANDA

IPC分类号： C07D487/10 ,  C07D207/08 ,  A61P35/00

CPC分类号： C07D487/10 ,  C07D207/08 ,  A61P35/00

摘要： The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.