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公开(公告)号：US20230142285A1
公开(公告)日：2023-05-11
申请号：US17604818
申请日：2020-12-17
发明人： Wei CAI , Xuedong DAI , Oliver Alexis Georges QUEROLLE , Johannes Wilhelmus John F. THURING , Yingtao LIU , Lianzhu LIU , Yanping XU , Liqiang FU , Ming LI , Lichao FANG , Xianguin DENG , Qiwu ZHAO , Kangying LI , Alicia Tee Fuay NG , Nicolas Freddy J. DARVILLE , Edward CLEATOR , Gregor Thomas URBANIETZ , William Marc MATON , Vineet PANDA
IPC分类号： C07D487/10 , C07D207/08 , A61P35/00
CPC分类号： C07D487/10 , C07D207/08 , A61P35/00
摘要： The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.
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公开(公告)号：US20230039917A1
公开(公告)日：2023-02-09
申请号：US17734413
申请日：2022-05-02
发明人： Xuedong DAI , Olivier Alexis Georges QUEROLLE , Daniel Jason KROSKY , Wei CAI , Liqiang FU , Linglong KONG , Yingtao LIU , Zhao-Kui WAN , Barbara MORSCHHÄUSER GEB. HERKERT , Vineet PANDE , James Patrick EDWARDS , Aaron Nathaniel PATRICK , Patrick René ANGIBAUD , Virginie Sophie PONCELET
IPC分类号： C07D495/04 , A61P35/00 , C07D519/00
摘要： The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, myelodysplastic syndrome (MDS) and diabetes.
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