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公开(公告)号：US09611259B2
公开(公告)日：2017-04-04
申请号：US14772040
申请日：2014-03-13
申请人： Janssen Pharmaceutica NV , Jie Chen , Matthew Donahue , Heng-Keang Lim , Ronghui Lin , Rhys Salter , Jiejun Wu
发明人： Jie Chen , Matthew Donahue , Heng-Keang Lim , Ronghui Lin , Rhys Salter , Jiejun Wu , Yong Gong
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
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2.发明申请METHOD FOR DETERMINING THE STABILITY OF ORGANIC METHYLENEAMINES IN THE PRESENCE OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE 审中-公开用于确定有机亚甲基氨基甲酸酯在半胱氨酸敏感胺氧化物存在下的稳定性的方法公开(公告)号：US20100028895A1
公开(公告)日：2010-02-04
申请号：US12518318
申请日：2008-01-08
申请人： Adedayo Adedoyin , Michael Angelastro , Julie Bick , Jennifer Cairns , Yongqing Huang , Guyan Liang , Heng-Keang Lim
发明人： Adedayo Adedoyin , Michael Angelastro , Julie Bick , Jennifer Cairns , Yongqing Huang , Guyan Liang , Heng-Keang Lim
CPC分类号： G01N33/5008 , C12Q1/26 , G01N2500/10 , G01N2560/00
摘要： The present invention provides methods for determining the stability of methyleneamine, methyleneamine-like compounds or compounds containing an methyleneamine moiety in the presence of semicarbazide-sensitive amine oxidase (SSAO) or a biological sample containing SSAO activity. The disclosed methods may be configured in an assay format for high throughput screening applications.
摘要翻译： 本发明提供了在存在氨基脲敏感性胺氧化酶（SSAO）或含有SSAO活性的生物样品的情况下测定亚甲基胺，亚甲基胺类化合物或含有亚甲基胺部分的化合物的稳定性的方法。 所公开的方法可以以用于高通量筛选应用的测定形式来配置。
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3.发明申请COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDENT GLUCOSE TRANSPORTER 有权具有抗依赖性葡萄糖输送机的抑制活性的化合物公开(公告)号：US20090029927A1
公开(公告)日：2009-01-29
申请号：US11949236
申请日：2007-12-03
IPC分类号： A61K31/7042 , A61P3/10 , C07H7/06
CPC分类号： C07D409/06
摘要： The invention is directed to compounds of the formula (I) described herein, a pharmaceutically acceptable salt thereof, or a prodrug thereof, and pharmaceutical compositions and methods of treatment.
摘要翻译： 本发明涉及本文所述的式（I）化合物，其药学上可接受的盐或其前药，以及药物组合物和治疗方法。
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4.发明授权Compounds having inhibitory activity against sodium-dependent glucose transporter 有权对钠依赖性葡萄糖转运蛋白具有抑制活性的化合物公开(公告)号：US07666845B2
公开(公告)日：2010-02-23
申请号：US11949236
申请日：2007-12-03
IPC分类号： A61K31/7012 , C07H15/26 , A61P3/10
CPC分类号： C07D409/06
摘要： The invention is directed to compounds of the formula (I) described herein, a pharmaceutically acceptable salt thereof, or a prodrug thereof, and pharmaceutical compositions and methods of treatment.
摘要翻译： 本发明涉及本文所述的式（I）化合物，其药学上可接受的盐或其前药，以及药物组合物和治疗方法。
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公开(公告)号：US10800764B2
公开(公告)日：2020-10-13
申请号：US16102005
申请日：2018-08-13
发明人： Jie Chen , Matthew Donahue , Heng-Keang Lim , Ronghui Lin , Rhys Salter , Jiejun Wu , Yong Gong
IPC分类号： C07D405/14
摘要： The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
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公开(公告)号：US10071991B2
公开(公告)日：2018-09-11
申请号：US15440182
申请日：2017-02-23
发明人： Jie Chen , Matthew Donahue , Heng-Keang Lim , Ronghui Lin , Rhys Salter , Jiejun Wu , Yong Gong
IPC分类号： C07D405/14
摘要： The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
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公开(公告)号：US11214566B2
公开(公告)日：2022-01-04
申请号：US17010132
申请日：2020-09-02
发明人： Jie Chen , Matthew Donahue , Heng-Keang Lim , Ronghui Lin , Rhys Salter , Jiejun Wu , Yong Gong
IPC分类号： C07D405/14
摘要： The present invention is directed to substituted pyridine derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives in the treatment of disorders mediated by c-fms kinase. The present invention is further directed to a process for the preparation of said substituted pyridine derivatives.
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