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![Antibacterial cyclopenta[c]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones](/abs-image/US/2018/12/18/US10155759B2/abs.jpg.150x150.jpg)
公开(公告)号：US10155759B2
公开(公告)日：2018-12-18
申请号：US15845854
申请日：2017-12-18
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , A61K31/495 , A61K31/44 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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![Antibacterial cyclopental[C]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones](/abs-image/US/2017/04/11/US09617262B2/abs.jpg.150x150.jpg)
公开(公告)号：US09617262B2
公开(公告)日：2017-04-11
申请号：US15071612
申请日：2016-03-16
发明人： Jerome Emile Georges Guillemont , David Francis Alain Lancois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , A61K31/44 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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3.发明申请公开(公告)号：US20160304531A1
公开(公告)日：2016-10-20
申请号：US14781291
申请日：2014-03-28
发明人： Jean-Francois Bonfanti , Jerome Michel Claude Fortin , Philippe Muller , Frederic Marc Maurice Doublet , Pierre Jean-Marie Bernard Raboisson , Eric Pierre Alexandre Arnoult
IPC分类号： C07D491/18 , C07D471/18 , C07D498/18 , C07D491/22
CPC分类号： C07D491/18 , C07D471/18 , C07D491/22 , C07D498/18 , C07D498/22
摘要： This invention relates to macrocyclic deaza-purinones derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
摘要翻译： 本发明涉及大环脱氮嘌呤酮衍生物，其制备方法，药物组合物及其在治疗病毒感染中的用途。
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公开(公告)号：US10266543B2
公开(公告)日：2019-04-23
申请号：US14781291
申请日：2014-03-28
发明人： Jean-François Bonfanti , Jérôme Michel Claude Fortin , Philippe Muller , Frédéric Marc Maurice Doublet , Pierre Jean-Marie Bernard Raboisson , Eric Pierre Alexandre Arnoult
IPC分类号： C07D491/18 , C07D491/22 , C07D498/18 , C07D498/22 , C07D471/18
摘要： This invention relates to macrocyclic deaza-purinones derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
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![ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES](/abs-image/US/2019/03/21/US20190084982A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190084982A1
公开(公告)日：2019-03-21
申请号：US16194052
申请日：2018-11-16
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , C07D519/00 , C07D487/04
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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![ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES](/abs-image/US/2017/06/22/US20170174683A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170174683A1
公开(公告)日：2017-06-22
申请号：US15454703
申请日：2017-03-09
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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公开(公告)号：US10280180B2
公开(公告)日：2019-05-07
申请号：US14408681
申请日：2013-07-12
发明人： Jean-Francois Bonfanti , Jerome Michel Claude Fortin , Philippe Muller , Frederic Marc Maurice Doublet , Pierre Jean-Marie Bernard Raboisson , Eric Pierre Alexandre Arnoult
IPC分类号： C07D498/22 , C07D487/16 , C07D498/16 , C07D487/22
摘要： This invention relates macrocyclic purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
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![Antibacterial cyclopenta[C]pyrrole substituted 3,4-Dihydro-1H-[1,8]naphthyridinones](/abs-image/US/2018/02/06/US09884864B2/abs.jpg.150x150.jpg)
公开(公告)号：US09884864B2
公开(公告)日：2018-02-06
申请号：US15454703
申请日：2017-03-09
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , A61K31/50 , A61K31/495 , A61K31/44 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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![ANTIBACTERIAL CYCLOPENTAL[C]PYRROLE SUBSTITUTED 3,4 DIHYDRO-1H-[1,8]NAPHTHYRIDINONES](/abs-image/US/2016/07/07/US20160194324A1/abs.jpg.150x150.jpg)
9.发明申请ANTIBACTERIAL CYCLOPENTAL[C]PYRROLE SUBSTITUTED 3,4 DIHYDRO-1H-[1,8]NAPHTHYRIDINONES 有权取代3,4-二氢-1H- [1,8]萘啶酮的抗菌素环[C]吡咯烷公开(公告)号：US20160194324A1
公开(公告)日：2016-07-07
申请号：US15071612
申请日：2016-03-16
发明人： Jerome Emile Georges Guillemont , David Francis Alain Lancois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
摘要翻译： 本发明涉及抑制因此可用于治疗细菌感染的FabI酶的活性的式（I）化合物。 它还涉及包含这些化合物的药物组合物和用于制备这些化合物的化学方法。
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![ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES](/abs-image/US/2018/04/19/US20180105525A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180105525A1
公开(公告)日：2018-04-19
申请号：US15845854
申请日：2017-12-18
发明人： Jerôme Emile Georges Guillemont , David Francis Alain Lançois , Magali Madeleine Simone Motte , Anil Koul , Wendy Mia Albert Balemans , Eric Pierre Alexandre Arnoult
IPC分类号： C07D471/04 , C07D519/00 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of bacterial infections. It further relates to pharmaceutical compositions comprising these compounds, and chemical processes for preparing these compounds.
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