公开(公告)号：US20220362368A1

公开(公告)日：2022-11-17

申请号：US17764434

申请日：2020-10-02

申请人： Janssen Vaccines & Prevention B.V. ,  The University of Chicago

发明人： Jan Theunis POOLMAN ,  Olaf SCHNEEWIND ,  Dominique MISSIAKAS ,  Yan SUN ,  Hwan Keun KIM ,  Miaomiao SHI ,  Xinhai CHEN ,  Jeffrey A. FERNANDEZ

IPC分类号： A61K39/085 ,  A61P31/04

摘要： Provided herein are immunogenic compositions comprising a Staphylococcus aureus protein A (SpA) variant and a mutant staphylococcal leukocidin subunit polypeptide comprising a LukA polypeptide, a LukB polypeptide, and/or a LukAB dimer polypeptide, wherein the LukA polypeptide, the LukB polypeptide, and/or the LukAB dimer polypeptide have one or more amino acid substitutions, deletions, or a combination thereof.

公开(公告)号：US20160074497A1

公开(公告)日：2016-03-17

申请号：US14888873

申请日：2014-05-02

申请人： The University of Chicago

发明人： Fabiana FALUGI ,  Hwan Keun KIM ,  Dominique MISSIAKAS ,  Olaf SCHNEEWIND

IPC分类号： A61K39/085 ,  C07K14/31

CPC分类号： A61K39/085 ,  A61K2039/522 ,  C07K14/31

摘要： Staphylococcus aureus protein A variants, defective in immunoglobulin binding, elicit protective immunity against staphylococcal disease. The present invention includes methods for preventing or ameliorating staphylococcal infections, particularly hospital acquired nosocomial infections. As such, the invention contemplates vaccines for use in both active and passive immunization embodiments. In certain embodiments the vaccine is an isolated recombinant staphylococcal bacteria that expresses a variant Protein A (SpA variant) comprising (a) at least one amino acid substitution that disrupts Fc binding and (b) at least a second amino acid substitution that disrupts VH3 binding variant in at least one of SpA A, B, C, D, and/or E domains.

摘要翻译： 金黄色葡萄球菌蛋白A型变体，免疫球蛋白结合缺陷，引起对葡萄球菌病的保护性免疫。 本发明包括预防或改善葡萄球菌感染，特别是医院获得性医院感染的方法。 因此，本发明设想用于主动和被动免疫实施方案中的疫苗。 在某些实施方案中，疫苗是表达变体蛋白A（SpA变体）的分离的重组葡萄球菌，其包含（a）破坏Fc结合的至少一个氨基酸取代和（b）破坏VH3结合的至少第二氨基酸取代 在SpA A，B，C，D和/或E结构域中的至少一个中的变体。

公开(公告)号：US20220323563A1

公开(公告)日：2022-10-13

申请号：US17595252

申请日：2020-05-13

申请人： The University of Chicago

发明人： Olaf SCHNEEWIND ,  Dominique MISSIAKAS ,  Yan SUN ,  Hwan Keun KIM ,  Miaomiao SHI ,  Xinhai CHEN

IPC分类号： A61K39/085 ,  C07K14/31 ,  A61K47/42

摘要： Embodiments concern methods and composition for preventing or treating a bacterial infection, particularly infection by a Staphylococcus bacterium. The embodiments concern improved non-toxigenic Protein A (SpA) variant.