公开(公告)号：US20220323563A1

公开(公告)日：2022-10-13

申请号：US17595252

申请日：2020-05-13

申请人： The University of Chicago

发明人： Olaf SCHNEEWIND ,  Dominique MISSIAKAS ,  Yan SUN ,  Hwan Keun KIM ,  Miaomiao SHI ,  Xinhai CHEN

IPC分类号： A61K39/085 ,  C07K14/31 ,  A61K47/42

摘要： Embodiments concern methods and composition for preventing or treating a bacterial infection, particularly infection by a Staphylococcus bacterium. The embodiments concern improved non-toxigenic Protein A (SpA) variant.

公开(公告)号：US20220362368A1

公开(公告)日：2022-11-17

申请号：US17764434

申请日：2020-10-02

申请人： Janssen Vaccines & Prevention B.V. ,  The University of Chicago

发明人： Jan Theunis POOLMAN ,  Olaf SCHNEEWIND ,  Dominique MISSIAKAS ,  Yan SUN ,  Hwan Keun KIM ,  Miaomiao SHI ,  Xinhai CHEN ,  Jeffrey A. FERNANDEZ

IPC分类号： A61K39/085 ,  A61P31/04

摘要： Provided herein are immunogenic compositions comprising a Staphylococcus aureus protein A (SpA) variant and a mutant staphylococcal leukocidin subunit polypeptide comprising a LukA polypeptide, a LukB polypeptide, and/or a LukAB dimer polypeptide, wherein the LukA polypeptide, the LukB polypeptide, and/or the LukAB dimer polypeptide have one or more amino acid substitutions, deletions, or a combination thereof.