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1.发明申请公开(公告)号：US20090233929A1
公开(公告)日：2009-09-17
申请号：US12083375
申请日：2006-10-12
申请人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
发明人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
IPC分类号： A61K31/5377 , A61K31/44 , A61K31/415 , C07D413/02 , C07D401/00 , C07D233/02
CPC分类号： C07D233/64 , C07D233/90 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/06 , C07D417/06
摘要： This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新颖的咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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2.发明申请Benzimidazole Derivatives and Their Use for Modulating the GABA-Alpha Receptor Complex 失效苯并咪唑衍生物及其用于调节GABA-α受体复合物的用途公开(公告)号：US20090048321A1
公开(公告)日：2009-02-19
申请号：US12085769
申请日：2006-12-04
IPC分类号： A61K31/4184 , C07D235/06 , A61P25/28 , A61P25/18 , A61P25/22
CPC分类号： C07D235/06
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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3.发明申请BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX 有权苯并咪唑衍生物及其用于调节GABA A受体复合物的用途公开(公告)号：US20110118259A1
公开(公告)日：2011-05-19
申请号：US13009988
申请日：2011-01-20
IPC分类号： A61K31/5377 , C07D401/10 , A61K31/4439 , C07D403/10 , A61K31/4184 , A61K31/506 , C07D413/10 , A61K31/496 , A61P25/00 , A61P29/00 , A61P3/00
CPC分类号： C07D235/06 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D413/04
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗对调节GABA A受体复合物有反应的中枢神经系统疾病和病症，特别是用于对抗焦虑和相关疾病。
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4.发明申请IMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA ALPHA RECEPTOR COMPLEX 失效咪唑衍生物及其用于调节GABA ALPHA受体复合物的用途公开(公告)号：US20090209597A1
公开(公告)日：2009-08-20
申请号：US12089883
申请日：2006-10-12
申请人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
发明人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
IPC分类号： A61K31/4439 , C07D233/90 , A61K31/4164 , C07D401/12 , A61P25/00
CPC分类号： C07D233/90 , C07D401/10 , C07D401/12 , C07D403/12
摘要： This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新颖的咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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5.发明申请Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex 审中-公开苯并咪唑衍生物及其用于调节gaba-α受体复合物的用途公开(公告)号：US20090062304A1
公开(公告)日：2009-03-05
申请号：US11918681
申请日：2006-04-18
IPC分类号： C07D403/10 , A61K31/496 , A61P25/00 , A61P25/18 , A61P25/30 , A61P25/28 , A61P25/06
CPC分类号： C07D235/06
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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6.发明申请Benzimidazole Derivatives and Their Use for Modulating the GABA Alpha Receptor Complex 失效苯并咪唑衍生物及其用于调节GABAα受体复合物的用途公开(公告)号：US20090036493A1
公开(公告)日：2009-02-05
申请号：US11887780
申请日：2006-04-07
IPC分类号： A61K31/4439 , C07D403/02 , C07D277/20 , C07D401/02 , A61P25/18 , A61P25/24 , A61P25/28 , A61K31/4184 , A61K31/427
CPC分类号： C07D403/10 , C07D401/10 , C07D417/10
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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7.发明申请BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX 有权苯并咪唑衍生物及其用于调节GABA A受体复合物的用途公开(公告)号：US20090036476A1
公开(公告)日：2009-02-05
申请号：US12279511
申请日：2007-03-22
IPC分类号： A61K31/506 , C07D235/06 , C07D403/10 , C07D401/10 , A61P3/10 , A61P25/28 , A61K31/4439 , A61K31/4184
CPC分类号： C07D235/06 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D413/04
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗对调节GABA A受体复合物有反应的中枢神经系统疾病和病症，特别是用于对抗焦虑和相关疾病。
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8.发明申请Benzimidazole derivatives and their use for modulating the gabaalpha receptor complex 失效苯并咪唑衍生物及其用于调节gabaalpha受体复合物的用途公开(公告)号：US20090030018A1
公开(公告)日：2009-01-29
申请号：US11918679
申请日：2006-04-18
IPC分类号： C07D235/12 , A61K31/4184 , A61K31/4439 , C07D401/12 , C07D403/12 , C07D417/12 , A61K31/506 , A61K31/4196 , A61K31/427 , A61P25/00 , A61P25/28 , A61P25/18 , A61P25/24
CPC分类号： C07D235/06 , C07D401/12 , C07D417/12
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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9.发明申请Imidazole Derivatives and Their Use for Modulating the Gabaa Receptor Complex 审中-公开咪唑衍生物及其用于调节Gabaa受体复合物的用途公开(公告)号：US20080312303A1
公开(公告)日：2008-12-18
申请号：US12089859
申请日：2006-10-12
申请人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
发明人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
IPC分类号： A61K31/4184 , A61P25/00 , C07D235/04
CPC分类号： C07D233/64 , C07D233/56
摘要： This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新颖的咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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10.发明授权Benzimidazole derivatives and their use for modulating the GABAA receptor complex 有权苯并咪唑衍生物及其用于调节GABA A受体复合物的用途公开(公告)号：US08288418B2
公开(公告)日：2012-10-16
申请号：US13009988
申请日：2011-01-20
IPC分类号： A61K31/4439 , C07D401/10
CPC分类号： C07D235/06 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D413/04
摘要： Benzimidazole derivatives, pharmaceutical compositions containing them, and methods of treatment therewith involving modulation of the GABAA receptor complex. The compounds have the formula I: wherein the variables are as described in the specification. The compounds are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 苯并咪唑衍生物，含有它们的药物组合物及其涉及调节GABA A受体复合物的方法。 化合物具有式I：其中变量如说明书中所述。 该化合物可用于治疗对调节GABA A受体复合物有反应的中枢神经系统疾病和病症，特别是用于对抗焦虑和相关疾病。
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