公开(公告)号：US09683997B2

公开(公告)日：2017-06-20

申请号：US14973240

申请日：2015-12-17

申请人： Japan Health Sciences Foundation

发明人： Seiichiro Mori ,  Tadahito Kanda

IPC分类号： C12Q1/70 ,  G01N33/68 ,  C07K16/08 ,  G01N33/574 ,  A61K47/48 ,  G01N33/569 ,  A61K39/00

CPC分类号： G01N33/6854 ,  A61K47/6901 ,  A61K2039/505 ,  C07K16/084 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q1/70 ,  G01N33/56983 ,  G01N33/57411 ,  G01N2333/025 ,  G01N2800/26 ,  G01N2800/52

摘要： The present invention relates to the development of a monoclonal antibody which has binding activity to many high-risk types of HPV, etc. The present invention also provides a simple and high-throughput method for measuring cross-neutralizing antibody titers, which is used for assay of cross-neutralizing antibody against HPV in serum samples from subjects, etc. The method of the present invention for measuring cross-neutralizing antibody titers comprises the steps of: preparing a monoclonal antibody against a peptide having a specific amino acid sequence common to high-risk types of HPV; and assaying cross-neutralizing antibody using this monoclonal antibody.