公开(公告)号：US20150192590A1

公开(公告)日：2015-07-09

申请号：US14422055

申请日：2013-08-13

Applicant: Japan Science and Technology Agency

Inventor： Mikiko SODEOKA ,  Jun ANDO ,  Miwako ASANUMA ,  Kosuke DODO ,  Katsumasa FUJITA

IPC: G01N33/68 ,  G01N33/58

CPC classification number: G01N33/6845 ,  C12N9/6472 ,  C12Y304/22001 ,  G01N21/65 ,  G01N21/658 ,  G01N27/44726 ,  G01N30/7233 ,  G01N30/74 ,  G01N30/78 ,  G01N33/587 ,  G01N2570/00 ,  H01J49/004 ,  H01J49/0418

Abstract: The present invention provides an apparatus having a sample separation unit, a Raman spectroscopy unit, and a mass spectrometry unit. The present invention further provides a method for specifying a biomolecule and a method for identifying the binding site of the biomolecule and the low-molecular-weight compound, comprising a combination of Raman spectroscopy and mass spectrometry. The present invention further provides a surface-enhanced Raman spectroscopy method with improved sensitivity.

Abstract translation: 本发明提供一种具有样品分离单元，拉曼光谱单元和质谱分析单元的装置。 本发明还提供了用于确定生物分子的方法和用于鉴定生物分子和低分子量化合物的结合位点的方法，其包括拉曼光谱和质谱联用。 本发明还提供了具有改进的灵敏度的表面增强拉曼光谱法。

公开(公告)号：US20180136040A1

公开(公告)日：2018-05-17

申请号：US15547652

申请日：2016-01-29

Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

Inventor： Mikiko SODEOKA ,  Katsumasa FUJITA ,  Jun ANDO

IPC: G01J3/02 ,  G01N21/65 ,  G01N21/64 ,  G01J3/36

Abstract: A multifocal spectrometric device is capable of simultaneously performing a measurement of a plurality of sample with high sensitivity, with no restriction on the magnification. A multifocal spectrometric device is a device in which beams of signal light emitted from a plurality of predetermined observation areas on samples placed in a sample placement section are introduced into a spectrograph and thereby dispersed into spectra, the device including: a plurality of objective lenses (objective light-condensing sections) individually located at positions which respectively and optically face the plurality of observation areas; and spectrograph input sections provided in such a manner that each of the plurality of objective lenses has one corresponding spectrograph input section, for introducing signal light passing through the corresponding objective lenses into the spectrograph. Since each objective lens only needs to observe one observation area, both the magnification and the numerical aperture can be simultaneously increased.