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1.发明公开公开(公告)号：US20240310356A1
公开(公告)日：2024-09-19
申请号：US18672910
申请日：2024-05-23
发明人： Ping Xie
IPC分类号： G01N33/487 , B01L3/00 , C12Q1/6869 , G01N27/414 , G01N27/416 , G01N27/447
CPC分类号： G01N33/48721 , B01L3/502715 , B01L3/50273 , C12Q1/6869 , G01N27/4145 , G01N27/4146 , G01N27/4163 , G01N27/44726 , G01N27/4473 , G01N27/44791 , B01L2300/0645 , B01L2300/0867 , B01L2300/0896 , B01L2300/12 , B01L2400/0421
摘要： A nanopore sensor includes a nanopore disposed in a support structure with a nanopore diameter and having a nanopore fluidic resistance, RPore. A fluidic passage, is disposed in fluidic connection between a first fluidic reservoir of ionic concentration solution and the nanopore, and includes a passage length having a fluidic passage width, along at least a portion of a fluidic passage length, that is greater than the diameter of the nanopore and less than the fluidic passage length. The fluidic passage has a fluidic passage fluidic resistance, RFP, of at least about 10% of the nanopore fluidic resistance, RPore, and no more than about 10 times the nanopore fluidic resistance, RPore. The nanopore is disposed in fluidic connection between the fluidic passage and a second fluidic reservoir of ionic concentration solution. At least one transistor is operatively connected electrically to sense electrical potential local to the fluidic passage.
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2.发明授权公开(公告)号：US12031913B2
公开(公告)日：2024-07-09
申请号：US15036181
申请日：2013-12-25
申请人： Hitachi, Ltd.
发明人： Takashi Anazawa , Takahide Yokoi , Yuichi Uchiho
IPC分类号： G01N21/64 , B01L3/00 , G01N21/03 , G01N21/05 , G01N27/447
CPC分类号： G01N21/6454 , B01L3/5027 , G01N21/6402 , G01N21/6452 , G01N27/447 , G01N27/44721 , G01N27/44726 , G01N27/44791 , B01L2300/0858 , B01L2300/0864 , G01N2021/0346 , G01N21/05 , G01N2201/06113
摘要： Efficient simultaneous laser-irradiation-fluorescence detection is performed for a plurality of channels of a microchip and simple and highly sensitive parallel analysis of a plurality of samples is enabled. In a microchip 1 made of an optically transparent solid material m1 with a refractive index n1, a plurality of channels 2 filled with a material m2 with a refractive index n2 and a plurality of channels 3 filled with a material m3 with a refractive index n3 are alternately arranged in parallel on the same plane. Here, m1, m2 and m3 are selected such that a relation of n2
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3.发明公开公开(公告)号：US20240183820A1
公开(公告)日：2024-06-06
申请号：US18345798
申请日：2023-06-30
申请人： ProteinSimple
发明人： David J. ROACH , Tom Weisan YANG , Hui XU
IPC分类号： G01N27/447 , G01N21/05 , G01N30/74
CPC分类号： G01N27/44791 , G01N27/447 , G01N27/44704 , G01N27/44743 , G01N27/44747 , G01N21/05 , G01N27/44721 , G01N27/44726 , G01N27/44795 , G01N30/74
摘要： A system includes a housing, a cartridge retainer disposed within the housing, a detection assembly disposed within the housing, and a reagent tray holder movably disposed in the housing. The cartridge retainer configured to receive a capillary cartridge having a capillary. The detection assembly includes at least one emitter, a first detector, and a second detector. The detection assembly is configured to transition between a first configuration, in which the first detector detects a first output of the at least one emitter, and a second configuration, in which the second detector detects a second output of the at least one emitter. The reagent tray holder is configured to move relative to the cartridge retainer to place the capillary of the capillary cartridge in fluid communication with a reagent volume.
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公开(公告)号：US11940413B2
公开(公告)日：2024-03-26
申请号：US17194850
申请日：2021-03-08
发明人： Steven Gordon , Thomas Hagerott , Edmund Golaski , Jerzy Olejnik
IPC分类号： C12Q1/68 , B01L3/00 , C12Q1/6869 , G01N27/447
CPC分类号： G01N27/44791 , B01L3/502761 , C12Q1/6869 , G01N27/44726 , B01L3/502715 , B01L2200/0668 , B01L2300/0877 , B01L2400/0487
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively small area to be imaged, in order to provide greater flexibility and efficiency.
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公开(公告)号：US11782024B2
公开(公告)日：2023-10-10
申请号：US18146834
申请日：2022-12-27
发明人： Jicun Ren , Xiangyi Huang , Meilisha Xu
IPC分类号： G01N27/453 , G01N21/76 , G01N27/447
CPC分类号： G01N27/44756 , G01N21/76 , G01N27/44726
摘要： A capillary array electrophoresis (CAE)-chemiluminescence (CL) detection coupled system includes a high-voltage power supply, a capillary array, an array channel CL reaction tank, a CAE sample tank, a CAE detection tank, a chemiluminescent reagent delivery unit, a multi-channel detection unit, and a data acquisition and processing unit. An inlet end of the capillary array is connected to the CAE sample tank. An outlet end of the capillary array is connected to the array channel CL reaction tank, and is further connected to the CAE detection tank.
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公开(公告)号：US20180169660A1
公开(公告)日：2018-06-21
申请号：US15894630
申请日：2018-02-12
申请人： ANDE CORPORATION
发明人： Eugene Tan , Heung Chuan Lam , Valery Leonidovich Bogdanov , Gregory John Kellogg , John A. Wright , Ulrich Hans Thomann , Richard F. Selden
IPC分类号： B01L7/00 , G01N21/64 , G01N27/447 , B01L3/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L2200/0684 , B01L2200/10 , B01L2200/147 , B01L2300/0627 , B01L2300/0654 , B01L2300/069 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0887 , B01L2300/16 , B01L2300/1822 , B01L2300/1844 , B01L2300/1894 , B01L2400/0421 , C12Q1/686 , C12Q1/6869 , G01N21/6402 , G01N21/6428 , G01N21/6452 , G01N21/6486 , G01N27/44726 , G01N27/44743 , G01N27/44782 , G01N27/44791 , G01N2021/6441 , G01N2201/06113 , Y10T436/2575
摘要： The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.
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公开(公告)号：US09885687B2
公开(公告)日：2018-02-06
申请号：US14856852
申请日：2015-09-17
发明人： Ulrich Rant , Wolfgang Kaiser , Paul Andreas Hampel , Jens Niemax , Andreas Langer , Jelena Knezevic
IPC分类号： G01N27/447 , C12Q1/68 , G01N21/64 , G01N33/543 , G01N27/327
CPC分类号： G01N27/44726 , C12Q1/6823 , C12Q1/6825 , G01N21/6408 , G01N21/6458 , G01N27/327 , G01N27/44756 , G01N33/5438 , G01N2021/6432 , C12Q2537/165 , C12Q2561/12 , C12Q2563/116
摘要： Arrangements are described for evaluating characteristics of target molecules. A biochip is received which includes a substrate to which charged probe molecules are attached. The probe molecules have a marker to allow generating signals indicative of the distance of a portion of the probe molecule from the substrate. The signals are detected and means for an external electric field is generated to which the probe molecules are exposed. A control means acts to: (A) apply an external electric field causing the portion of the probe molecule to approach the substrate, and (B) apply an external electric field causing the portion of the probe molecule to move away from the substrate. The signal is recorded as a function of time during step (A) and/or step (B). Steps (A) and (B) are repeated for a predetermined number of times and the recorded signals are combined.
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公开(公告)号：US20180017525A1
公开(公告)日：2018-01-18
申请号：US15656307
申请日：2017-07-21
发明人： Steven Gordon , Thomas Hagerott , Edmund Golaski , Jerzy Olejnik
IPC分类号： G01N27/447 , C12Q1/68 , B01L3/00
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2400/0487 , C12Q1/6869 , G01N27/44726
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively small area to be imaged, in order to provide greater flexibility and efficiency.
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公开(公告)号：US09823222B2
公开(公告)日：2017-11-21
申请号：US15471699
申请日：2017-03-28
发明人： Ho-ming Pang , Wei Wei
IPC分类号： G01N27/447 , G01N21/64
CPC分类号： G01N27/44791 , G01N21/6428 , G01N27/44721 , G01N27/44726
摘要： A multiple capillary florescent detection system employing optical fiber bundles that each fiber bundle has more than one fiber illuminating each sample vessel.
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10.发明申请公开(公告)号：US20170315088A1
公开(公告)日：2017-11-02
申请号：US15520726
申请日：2014-10-23
申请人： Analogic Corporation
发明人： Ching-Ming LAI
IPC分类号： G01N27/447 , G06F19/18 , G01N15/14 , B01L3/00 , G06F19/26
CPC分类号： G01N27/44726 , B01L3/502761 , B01L2300/0654 , B01L2400/0421 , G01N15/14 , G01N27/44782 , G01N27/44791 , G01N2015/1493 , G16B20/00 , G16B40/00 , G16B45/00 , G16B99/00
摘要： A sample processing apparatus (102) includes a plurality of processing stations (108) configured to process a sample that includes a DNA sample and an ILS substance carried by a sample carrier. One of the plurality of processing stations includes an electrophoresis processing station. The sample processing apparatus further includes an optical reader (110) that generates a plurality of DNA sample color group signals and an ILS signal based on a result of the electrophoresis processing station. One of the DNA sample color group signals includes at least the locus amelogenin X-peak. The sample processing apparatus further includes an ILS signal validator (112) that validates peaks of the ILS signal as true peaks of the ILS signal only if the amelogenin X-peak of the one of the DNA sample color group signals is found between two peaks of the ILS signal.
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