利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

15 条记录 (耗时 0.045 秒)

    Cyclosporins for the treatment of immune disorders
    8.
    发明授权
    Cyclosporins for the treatment of immune disorders 失效
    环孢菌素治疗免疫障碍

    公开(公告)号：US07012065B2

    公开(公告)日：2006-03-14

    申请号：US10360894

    申请日：2003-02-07

    申请人： Yat Sun Or ,  Tsvetelina Lazarova ,  Jason Shih-Hao Chen

    发明人： Yat Sun Or ,  Tsvetelina Lazarova ,  Jason Shih-Hao Chen

    IPC分类号： A61K38/13 ,  C07K7/64

    CPC分类号： C07K7/645 ,  A61K38/00 ,  Y02P20/55

    摘要： The present invention relates to novel semi-synthetic cyclosporin analogs for the prevention of organ transplantation rejection and the treatment of immune disorders and inflammation, their use as pharmaceuticals and pharmaceutical composition comprising them, as well as the processes for the their production. The present invention provides a cyclosporin compound of the following Formula (1) or its pharmaceutically acceptable salt, ester or prodrug thereof. In the compound of Formula (1), moiety “A” is Wherein “X” and “Y” are defined herein.

    摘要翻译： 本发明涉及用于预防器官移植排斥和治疗免疫疾病和炎症的新型半合成环孢菌素类似物，其用作药物和包含它们的药物组合物，以及其制备方法。 本发明提供下式（1）的环孢菌素化合物或其药学上可接受的盐，酯或前药。 在式（1）的化合物中，部分“A”是其中“X”和“Y”在本文中定义的。

    Cyclosporins for the treatment of immune disorders
    9.
    发明授权
    Cyclosporins for the treatment of immune disorders 失效
    环孢菌素治疗免疫障碍

    公开(公告)号：US06979671B2

    公开(公告)日：2005-12-27

    申请号：US10349877

    申请日：2003-01-23

    申请人： Yat Sun Or ,  Tsvetelina Lazarova ,  Jens Werner Eckstein

    发明人： Yat Sun Or ,  Tsvetelina Lazarova ,  Jens Werner Eckstein

    IPC分类号： A61K38/00 ,  C07K7/64

    CPC分类号： C07K7/645 ,  A61K38/00

    摘要： The present invention relates to a cyclosporin analog of the following formula (I) or its pro-drug or pharmaceutically acceptable salt: In formula I, the formula for residue A is: where X and Y are defined according to the claimed invention the present invention also relates to pharmaceutical compositions comprising pro-drugs or pharmaceutically acceptable salts of the compounds of the present invention and the use thereof for treating an inflammatory or immune disorder in a subject need of such treatment.

    摘要翻译： 本发明涉及下式（I）的环孢菌素类似物或其前药或药学上可接受的盐：在式I中，残基A的化学式为：其中X和Y根据要求保护的发明定义，本发明 还涉及包含本发明化合物的前药或药学上可接受的盐的药物组合物及其用于治疗受试者需要这种治疗的炎症或免疫疾病的用途。