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公开(公告)号：US07408025B2
公开(公告)日：2008-08-05
申请号：US09737908
申请日：2000-12-15
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xiang Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xiang Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
IPC分类号： C07K7/50
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
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公开(公告)号：US20090011977A1
公开(公告)日：2009-01-08
申请号：US12163225
申请日：2008-06-27
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xiang Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xiang Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
摘要翻译： 本发明涉及新型脂肽化合物。 本发明还涉及这些化合物的药物组合物和使用这些化合物作为抗菌化合物的方法。 本发明还涉及生产这些新型脂肽化合物的方法和用于生产这些化合物的中间体。
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公开(公告)号：US20080287347A1
公开(公告)日：2008-11-20
申请号：US12163299
申请日：2008-06-27
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xiang Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xiang Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
摘要翻译： 本发明涉及新型脂肽化合物。 本发明还涉及这些化合物的药物组合物和使用这些化合物作为抗菌化合物的方法。 本发明还涉及生产这些新型脂肽化合物的方法和用于生产这些化合物的中间体。
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公开(公告)号：US07335725B2
公开(公告)日：2008-02-26
申请号：US11121851
申请日：2005-05-04
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
IPC分类号： C07K7/50
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
摘要翻译： 本发明涉及新型脂肽化合物。 本发明还涉及这些化合物的药物组合物和使用这些化合物作为抗菌化合物的方法。 本发明还涉及生产这些新型脂肽化合物的方法和用于生产这些化合物的中间体。
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公开(公告)号：US06911525B2
公开(公告)日：2005-06-28
申请号：US09738742
申请日：2000-12-15
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
摘要翻译： 本发明涉及新型脂肽化合物。 本发明还涉及这些化合物的药物组合物和使用这些化合物作为抗菌化合物的方法。 本发明还涉及生产这些新型脂肽化合物的方法和用于生产这些化合物的中间体。
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公开(公告)号：US06794490B2
公开(公告)日：2004-09-21
申请号：US09739535
申请日：2000-12-15
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
IPC分类号： A61K3812
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
摘要翻译： 本发明涉及新型脂肽化合物。 本发明还涉及这些化合物的药物组合物和使用这些化合物作为抗菌化合物的方法。 本发明还涉及生产这些新型脂肽化合物的方法和用于生产这些化合物的中间体。
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公开(公告)号：US20050203006A1
公开(公告)日：2005-09-15
申请号：US11121851
申请日：2005-05-04
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan Watson , Yan Zhang
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
摘要翻译： 本发明涉及新型脂肽化合物。 本发明还涉及这些化合物的药物组合物和使用这些化合物作为抗菌化合物的方法。 本发明还涉及生产这些新型脂肽化合物的方法和用于生产这些化合物的中间体。
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公开(公告)号：US6153645A
公开(公告)日：2000-11-28
申请号：US393505
申请日：1999-09-10
申请人： John Finn , Xiang Yang Yu , Zhongguo Wang , Jason Hill , Dennis Keith , Paul Gallant , Philip Wendler
发明人： John Finn , Xiang Yang Yu , Zhongguo Wang , Jason Hill , Dennis Keith , Paul Gallant , Philip Wendler
IPC分类号： C07D491/048 , C07D491/10 , C07D493/10 , A61K31/34 , A61K31/40 , C07D493/04
CPC分类号： C07D491/10 , C07D493/10
摘要： Methods for treating infection and related compositions, compounds of formula I as defined in the application and methods for preparing same, are provided. In general, the compounds inhibit transfer ribonucleic acid (tRNA) synthetase and are useful as antimicrobial agents.
摘要翻译： 提供了治疗感染和相关组合物的方法，应用中定义的式I化合物及其制备方法。 通常，这些化合物抑制转移核糖核酸（tRNA）合成酶，并且可用作抗微生物剂。
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公开(公告)号：US06545015B2
公开(公告)日：2003-04-08
申请号：US09934743
申请日：2001-08-22
申请人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Jason Hill , Dennis Keith
发明人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Jason Hill , Dennis Keith
IPC分类号： C07D21500
CPC分类号： C07D233/64 , C07D215/14 , C07D231/12 , C07D233/56 , C07D235/12 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12
摘要： Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.
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公开(公告)号：US06348482B1
公开(公告)日：2002-02-19
申请号：US09566275
申请日：2000-05-05
申请人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Jason Hill , Dennis Keith
发明人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Jason Hill , Dennis Keith
IPC分类号： A01N4378
CPC分类号： C07D233/64 , C07D215/14 , C07D231/12 , C07D233/56 , C07D235/12 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12
摘要： Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.
摘要翻译： 化合物，药用盐及其组合物，其通式如下：其中Ar为芳基和杂芳基; R 1，R 2，R 3和R 4是氢，烷基，氰基，杂芳基，羟基，氨基，酰氨基，卤素，烷氧基，芳氧基，羧酰氨基，烯基，环烷基，杂环基，酰基，酰氧基，烷氧羰基，羧基， 和磺氧基，R5，R6，R7和R8是氢和低级烷基; Het是含氮杂环。
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