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    NEUROPSYCHIATRIC TEST REPORTS
    1.
    发明申请
    NEUROPSYCHIATRIC TEST REPORTS 有权
    神经病学测试报告

    公开(公告)号：US20130132114A1

    公开(公告)日：2013-05-23

    申请号：US13739970

    申请日：2013-01-11

    申请人： Jay L. LOMBARD

    发明人： Jay L. LOMBARD

    IPC分类号： G06F19/00 ,  G06Q50/22

    CPC分类号： G06Q50/22 ,  G06F19/00 ,  G06F19/18 ,  G06Q10/10 ,  G06Q50/24 ,  G16H15/00

    摘要： Methods and reports for presenting genetic information that is patient-specific and relevant to treatment of neuropsychiatric disorders, including treatment resistant psychiatric disorders, to aid in patient treatment in a phenotype, genotype or biomarker-specific manner. The methods and reports examine biomarkers for dysfunction of three axes relevant to treating neuropsychiatric disorders and provide interpretive comments to aid in treatment. Combining biomarker information from each of the three axes (the autonomic arousal axis, the emotional valence, attention, reward and executive brain function axis, and the long-term potentiation and long-term depression (LTP-LTD) function axis) provides an unexpectedly comprehensive and effective means for directing treatment of neuropsychiatric disorders, including particularly treatment resistant disorders (TRD).

    摘要翻译： 用于呈现遗传信息的方法和报告，所述遗传信息是患者特异性的并且与治疗神经精神障碍有关，包括治疗抗性精神障碍，以帮助患者治疗表型，基因型或生物标志物特异性方式。 方法和报告检查与治疗神经精神障碍相关的三个轴功能障碍的生物标志物，并提供解释性意见以帮助治疗。 结合三轴（自主唤醒轴，情感价值，注意力，奖励和执行大脑功能轴）以及长期增强和长期抑郁（LTP-LTD）功能轴）的生物标志物信息提供了意想不到的 指导治疗神经精神障碍，包括特别是治疗耐药障碍（TRD）的全面和有效的手段。

    METHODS FOR ASSESSMENT AND TREATMENT OF MOOD DISORDERS VIA SINGLE NUCLEOTIDE POLYMORPHISMS ANALYSIS
    2.
    发明申请
    METHODS FOR ASSESSMENT AND TREATMENT OF MOOD DISORDERS VIA SINGLE NUCLEOTIDE POLYMORPHISMS ANALYSIS 审中-公开
    通过单核苷酸多态性分析评估和治疗遗传病的方法

    公开(公告)号：US20140323424A1

    公开(公告)日：2014-10-30

    申请号：US14324524

    申请日：2014-07-07

    申请人： Jay L. LOMBARD

    发明人： Jay L. LOMBARD

    IPC分类号： A61K31/7076 ,  C12Q1/68 ,  A61K31/4015 ,  A61K31/554 ,  A61K31/41

    CPC分类号： A61K31/7076 ,  A61K31/4015 ,  A61K31/41 ,  A61K31/554 ,  C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

    摘要： Described herein are assays, kits and methods for treating mood disorders by testing for one or more polymorphisms in a specific group of genes and for analyzing the results of polymorphism testing; the genes included may converge in one or more signaling pathways, and may be epigenetic. The genes are included based on the relationships of the proteins encoded by the genes in the context of particular signaling pathways and provide a diagnostically relevant nexus. Also described herein are methods of presenting the data collected by the screen, including methods of delivering interpretive comments and/or treatment guidance based on the results of the genetic screening either individually or based on the genetic composition of particular clusters of genes which may be related to each other. Importantly, drugs which modulate these genetic disturbances are described for targeted therapeutic use based upon companion diagnostic method.

    摘要翻译： 本文描述的是通过测试特定基因组中的一个或多个多态性并分析多态性测试的结果来治疗情绪障碍的测定法，试剂盒和方法; 所包含的基因可能会聚合在一个或多个信号通路中，并且可能是表观遗传学。 基于在特定信号传导途径的上下文中由基因编码的蛋白质的关系包括基因并提供诊断上相关的联系。 本文还描述了呈现由屏幕收集的数据的方法，包括基于遗传筛选的结果单独地或基于可能相关的特定基因簇的遗传组成递送解释性评论和/或治疗指导的方法 对彼此。 重要的是，基于伴随诊断方法描述了调节这些遗传紊乱的药物用于靶向治疗用途。