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1.发明授权公开(公告)号：US07122524B2
公开(公告)日：2006-10-17
申请号：US10635805
申请日：2003-08-05
CPC分类号： A61K38/06
摘要： The invention relates to the use of specific tripeptides for the treatment of postlesional diseases of ischemic, traumatic or toxic origin. The tripeptide derivatives satisfy the following formula (I): (see formula I as in paper form) wherein X represents OH, (C1-5) alkoxy, NH2, NH—C1-5-alkyl, N(C1-5 alkyl)2; R1 is a residue derived from one of the amino acids Phe, Tyr, Trp, Pro, which each may be optionally substituted with one or more (C1-5) alkoxy groups, (C1-5) alkyl groups or halogen atoms, as well as Ala, Val, Leu or Ile; R2 is a residue derived from one of the amino acids Gly, Ala, Ile, Val, Ser, Thr, and Pro; Y1 and Y2 independently from each other represent H or (C1-5) alkyl; R3 and R4 independently from each other represent H, OH, (C1-5) alkyl or (C1-5) alkoxy, provided that R3 and R4 are not both OH or (C1-5) alkoxy; and R5 represents H, OH, (C1-5) alkyl or (C1-5) alkoxy; or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及特异性三肽用于治疗缺血性，创伤性或毒性起源性的postsional疾病的用途。 三肽衍生物满足下列通式（I）：（参见纸上形式的式I）其中X表示OH，（C 1-5 - ）烷氧基，NH 2， NH-C 1-5 - 烷基，N（C 1-5烷基）亚烷基。 R 1是衍生自氨基酸Phe，Tyr，Trp，Pro之一的残基，其各自可以任选地被一个或多个（C 1-5 - （C 1-5）烷基或卤素原子，以及Ala，Val，Leu或Ile; R 2是来源于氨基酸Gly，Ala，Ile，Val，Ser，Thr和Pro之一的残基; Y 1和Y 2彼此独立地表示H或（C 1-5烷基）烷基; R 3和R 4彼此独立地表示H，OH，（C 1-5烷基）烷基或（C 1〜 5 S）烷氧基，条件是R 3和R 4不同时为OH或（C 1-5）烷氧基; 和R 5表示H，OH，（C 1-5烷基）烷基或（C 1-5 H 5）烷氧基; 或其药学上可接受的盐。
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2.发明授权公开(公告)号：US07163922B2
公开(公告)日：2007-01-16
申请号：US10635808
申请日：2003-08-05
IPC分类号： A61K38/00
CPC分类号： A61K38/06
摘要： The invention relates to the use of specific tripeptides for the treatment of postlesional diseases of ischemic, traumatic or toxic origin. The tripeptide derivatives satisfy formula (I), wherein X represents OH, (C1-5)alkoxy, NH2, NH—C1-5-alkyl, N(C1-5 alkyl)2; R1 is a residue derived from any of the amino acids Phe, Tyr, Trp, Pro, each of which may optionally be substituted by a (C1-5) alkoxy group, a (C1-5) alkyl group or a halogen atom, and Ala, Val, Leu, or Ile; R2 is a residue which is derived from any of the amino acids Gly, Ala, Ile, Val, Ser, Thr, His, Arg, Lys, Pro, Glu, Gln, pGlu, Asp, Leu and Asn; R3 and R4 independently represent H, OH, (C1 –C5) alkyl, or (C1-5)alkoxy, provided that R3 and R4 are not both OH or (C1-5)alkoxy; R5 represents H, OH, (C1-5)alkyl or (C1-5)alkoxy; and wherein R0 preferably represents a cinnamoyl residue; or pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及特异性三肽用于治疗缺血性，创伤性或毒性起源性的postsional疾病的用途。 三肽衍生物满足式（I），其中X表示OH，（C 1-5 - ）烷氧基，NH 2，NH-C 1-5 - 亚烷基，N（C 1-5烷基）亚烷基; R 1是来自任何氨基酸Phe，Tyr，Trp，Pro的残基，其各自可任选地被（C 1-5 - ）烷氧基 （C 1-5）烷基或卤素原子，Ala，Val，Leu或Ile; R 2是衍生自任何氨基酸Gly，Ala，Ile，Val，Ser，Thr，His，Arg，Lys，Pro，Glu，Gln，pGlu，Asp，Leu的残基 和Asn; R 3和R 4独立地表示H，OH，（C 1 -C 5）烷基或（C 1-5 - ）烷氧基，条件是 R 3和R 4不同时为OH或（C 1-5 - ）烷氧基; R 5表示H，OH，（C 1-5 - ）烷基或（C 1-5 - ）烷氧基; 并且其中R 0优选表示肉桂酰残基; 或其药学上可接受的盐。
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3.发明授权Tripeptides and tripeptide derivatives for the treatment of neurodegenerative diseases 失效用于治疗神经变性疾病的三肽和三肽衍生物公开(公告)号：US07129213B2
公开(公告)日：2006-10-31
申请号：US10635797
申请日：2003-08-05
CPC分类号： C07K5/0823 , A61K38/00 , C07K5/08 , C07K5/0802
摘要： The invention relates to the use of specific tripeptides for the treatment of neurodegenerative diseases, and to pharmaceutical compositions comprising the tripeptides. The tripeptide derivatives satisfy the following formula (I): wherein X represents OH, (C1-5) alkoxy, NH2, NH—C1-5-alkyl, N(C1-5 alkyl)2; R1 is a residue derived from one of the amino acids Phe, Tyr, Trp, Pro, which each may be optionally substituted with one or more (C1-5)alkoxy groups, (C1-5)alkyl groups or halogen atoms, as well as Ala, Val, Leu or Ile; R2 is a residue derived from one of the amino acids Gly, Ala, Ile, Val, Ser, Thr, Leu and Pro; Y1 and Y2 independently from each other represent H or (C1-5)alkyl; R3 and R4 independently from each other represent H, OH, (C1-5)alkyl or (C1-5)alkoxy, provided that R3 and R4 are not both OH or (C1-5)alkoxy; and R5 represents H, OH, (C1-5)alkyl or (C1-5)alkoxy; or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及特异性三肽用于治疗神经变性疾病的用途，以及包含三肽的药物组合物。 三肽衍生物满足下式（I）：其中X表示OH，（C 1-5 - ）烷氧基，NH 2，NH-C 1-5 N（C 1-5烷基）亚烷基，N（C 1-5烷基） R 1是衍生自氨基酸Phe，Tyr，Trp，Pro之一的残基，其各自可以任选地被一个或多个（C 1-5 - （C 1-5）烷基或卤素原子，以及Ala，Val，Leu或Ile; R 2是衍生自氨基酸Gly，Ala，Ile，Val，Ser，Thr，Leu和Pro之一的残基; Y 1和Y 2彼此独立地表示H或（C 1-5烷基）烷基; R 3和R 4彼此独立地表示H，OH，（C 1-5烷基）烷基或（C 1〜 5 S）烷氧基，条件是R 3和R 4不同时为OH或（C 1-5）烷氧基; 和R 5表示H，OH，（C 1-5烷基）烷基或（C 1-5 H 5）烷氧基; 或其药学上可接受的盐。
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4.发明申请公开(公告)号：US20050080016A1
公开(公告)日：2005-04-14
申请号：US10635805
申请日：2003-08-05
申请人： Jean Rapin , Hans Witzmann , Jean-Marie Grumel , Jacques Gonella
发明人： Jean Rapin , Hans Witzmann , Jean-Marie Grumel , Jacques Gonella
IPC分类号： A61K38/00 , A61K38/06 , A61P9/10 , A61P17/02 , A61P25/00 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/097 , A61K38/08
CPC分类号： A61K38/06
摘要： The invention relates to the use of specific tripeptides for the treatment of postlesional diseases of ischemic, traumatic or toxic origin. The tripeptide derivatives satisfy the following formula (I): (see formula I as in paper form) wherein X represents OH, (C1-5) alkoxy, NH2, NH—C1-5-alkyl, N(C1-5 alkyl)2; R1 is a residue derived from one of the amino acids Phe, Tyr, Trp, Pro, which each may be optionally substituted with one or more (C1-5) alkoxy groups, (C1-5) alkyl groups or halogen atoms, as well as Ala, Val, Leu or Ile; R2 is a residue derived from one of the amino acids Gly, Ala, Ile, Val, Ser, Thr, and Pro; Y1 and Y2 independently from each other represent H or (C1-5) alkyl; R3 and R4 independently from each other represent H, OH, (C1-5) alkyl or (C1-5) alkoxy, provided that R3 and R4 are not both OH or (C1-5) alkoxy; and R5 represents H, OH, (C1-5) alkyl or (C1-5) alkoxy; or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及特异性三肽用于治疗缺血性，创伤性或毒性起源性的postsional疾病的用途。 三肽衍生物满足下式（I）：（参见式I），其中X表示OH，（C 1-5）烷氧基，NH 2，NH-C 1-5 - 烷基，N（C 1-5烷基）2 ; R1是衍生自氨基酸Phe，Tyr，Trp，Pro之一的残基，其各自可以任选地被一个或多个（C 1-5）烷氧基，（C 1-5）烷基或卤素原子取代 如Ala，Val，Leu或Ile; R2是衍生自氨基酸Gly，Ala，Ile，Val，Ser，Thr和Pro之一的残基; Y 1和Y 2彼此独立地表示H或（C 1-5）烷基; R 3和R 4彼此独立地表示H，OH，（C 1-5）烷基或（C 1-5）烷氧基，条件是R 3和R 4不同时为OH或（C 1-5）烷氧基; 并且R 5表示H，OH，（C 1-5）烷基或（C 1-5）烷氧基; 或其药学上可接受的盐。
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5.发明申请公开(公告)号：US20050192228A1
公开(公告)日：2005-09-01
申请号：US10635696
申请日：2003-08-05
申请人： Jean Rapin , Hans Witzmann , Jean-Marie Grumel , Jacques Gonella
发明人： Jean Rapin , Hans Witzmann , Jean-Marie Grumel , Jacques Gonella
CPC分类号： A61K38/06
摘要： The invention relates to the use of specific tripeptides for the treatment of neurodegenerative diseases. The tripeptide derivatives satisfy the following formula (I): wherein X represents OH, (C1-5)alkoxy, NH2, NH—C1-5-alkyl, N(C1-5alkyl)2; R1 is a residue derived from any of the amino acids Phe, Tyr, Trp, Pro, each of which may optionally be substituted by a (C1-5)alkoxy group, a (C1-5)alkyl group or a halogen atom, and Ala, Val, Leu, or Ile; R2 is a residue which is derived from any of the amino acids Gly, Ala, Ile, Val, Ser, Thr, His, Arg, Lys, Pro, Glu, Gln, pGlu, Asp, Leu and Asn; R3 and R4 independently represent H, OH, (C1-5)alkyl, or (C1-5)alkoxy, provided that R3 and R4 are not both OH or (C1-5)alkoxy; R5 represents H, OH, (C1-5)alkyl or (C1-5)alkoxy; and wherein R0 preferably represents a cinnamoyl residue; or pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及特异性三肽用于治疗神经变性疾病的用途。 三肽衍生物满足下式（I）：其中X表示OH，（C 1-5 - ）烷氧基，NH 2，NH-C 1-5 N（C 1-5烷基）亚烷基，N（C 1-5烷基） R 1是来自任何氨基酸Phe，Tyr，Trp，Pro的残基，其各自可任选地被（C 1-5 - ）烷氧基 （C 1-5）烷基或卤素原子，Ala，Val，Leu或Ile; R 2是衍生自任何氨基酸Gly，Ala，Ile，Val，Ser，Thr，His，Arg，Lys，Pro，Glu，Gln，pGlu，Asp，Leu的残基 和Asn; R 3和R 4独立地表示H，OH，（C 1-5 - ）烷基，或（C 1-5） 其中R 3和R 4不都是OH或（C 1-5 - ）烷氧基， R 5表示H，OH，（C 1-5 - ）烷基或（C 1-5 - ）烷氧基; 并且其中R 0优选表示肉桂酰残基; 或其药学上可接受的盐。
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6.发明申请公开(公告)号：US20050101539A1
公开(公告)日：2005-05-12
申请号：US10635808
申请日：2003-08-05
申请人： Jean Rapin , Hans Witzmann , Jean-Marie Grumel , Jacques Gonella
发明人： Jean Rapin , Hans Witzmann , Jean-Marie Grumel , Jacques Gonella
CPC分类号： A61K38/06
摘要： The invention relates to the use of specific tripeptides for the treatment of postlesional diseases of ischemic, traumatic or toxic origin. The tripeptide derivatives satisfy formula (I), wherein X represents OH, (C1-5)alkoxy, NH2, NH—C1-5-alkyl, N(C1-5 alkyl)2; R1 is a residue derived from any of the amino acids Phe, Tyr, Trp, Pro, each of which may optionally be substituted by a (C1-5) alkoxy group, a (C1-5) alkyl group or a halogen atom, and Ala, Val, Leu, or Ile; R2 is a residue which is derived from any of the amino acids Gly, Ala, Ile, Val, Ser, Thr, His, Arg, Lys, Pro, Glu, Gln, pGlu, Asp, Leu and Asn; R3 and R4 independently represent H, OH, (C1-C5) alkyl, or (C1-5)alkoxy, provided that R3 and R4 are not both OH or (C1-5)alkoxy; R5 represents H, OH, (C1-5)alkyl or (C1-5)alkoxy; and wherein R0 preferably represents a cinnamoyl residue; or pharmaceutically acceptable salts thereof.
摘要翻译： 本发明涉及特异性三肽用于治疗缺血性，创伤性或毒性起源性的postsional疾病的用途。 三肽衍生物满足式（I），其中X表示OH，（C 1-5 - ）烷氧基，NH 2，NH-C 1-5 - 亚烷基，N（C 1-5烷基）亚烷基; R 1是来自任何氨基酸Phe，Tyr，Trp，Pro的残基，其各自可任选地被（C 1-5 - ）烷氧基 （C 1-5）烷基或卤素原子，Ala，Val，Leu或Ile; R 2是衍生自任何氨基酸Gly，Ala，Ile，Val，Ser，Thr，His，Arg，Lys，Pro，Glu，Gln，pGlu，Asp，Leu的残基 和Asn; R 3和R 4独立地表示H，OH，（C 1 -C 5）烷基或（C 1-5 - ）烷氧基， 条件是R 3和R 4不同时为OH或（C 1-5 - ）烷氧基; R 5表示H，OH，（C 1-5 - ）烷基或（C 1-5 - ）烷氧基; 并且其中R 0优选表示肉桂酰残基; 或其药学上可接受的盐。
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7.发明申请Tripeptides and tripeptide derivatives for the treatment of neurodegenerative diseases 失效用于治疗神经变性疾病的三肽和三肽衍生物公开(公告)号：US20050101538A1
公开(公告)日：2005-05-12
申请号：US10635797
申请日：2003-08-05
申请人： Jean Rapin , Hans Witzmann , Jean-Marie Grumel , Jacques Gonella
发明人： Jean Rapin , Hans Witzmann , Jean-Marie Grumel , Jacques Gonella
CPC分类号： C07K5/0823 , A61K38/00 , C07K5/08 , C07K5/0802
摘要： The invention relates to the use of specific tripeptides for the treatment of neurodegenerative diseases, and to pharmaceutical compositions comprising the tripeptides. The tripeptide derivatives satisfy the following formula (I): wherein X represents OH, (C1-5) alkoxy, NH2, NH—C1-5-alkyl, N(C1-5 alkyl)2; R1 is a residue derived from one of the amino acids Phe, Tyr, Trp, Pro, which each may be optionally substituted with one or more (C1-5)alkoxy groups, (C1-5)alkyl groups or halogen atoms, as well as Ala, Val, Leu or Ile; R2 is a residue derived from one of the amino acids Gly, Ala, Ile, Val, Ser, Thr, Leu and Pro; Y1 and Y2 independently from each other represent H or (C1-5)alkyl; R3 and R4 independently from each other represent H, OH, (C1-5)alkyl or (C1-5)alkoxy, provided that R3 and R4 are not both OH or (C1-5)alkoxy; and R5 represents H, OH, (C1-5)alkyl or (C1-5)alkoxy; or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及特异性三肽用于治疗神经变性疾病的用途，以及包含三肽的药物组合物。 三肽衍生物满足下式（I）：其中X表示OH，（C 1-5 - ）烷氧基，NH 2，NH-C 1-5 N（C 1-5烷基）亚烷基，N（C 1-5烷基） R 1是衍生自氨基酸Phe，Tyr，Trp，Pro之一的残基，其各自可以任选地被一个或多个（C 1-5 - （C 1-5）烷基或卤素原子，以及Ala，Val，Leu或Ile; R 2是衍生自氨基酸Gly，Ala，Ile，Val，Ser，Thr，Leu和Pro之一的残基; Y 1和Y 2彼此独立地表示H或（C 1-5烷基）烷基; R 3和R 4彼此独立地表示H，OH，（C 1-5烷基）烷基或（C 1〜 5 S）烷氧基，条件是R 3和R 4不同时为OH或（C 1-5）烷氧基; 和R 5表示H，OH，（C 1-5烷基）烷基或（C 1-5 H 5）烷氧基; 或其药学上可接受的盐。
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