利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.031 秒)

    3-Aryl 2-oxazolidinones, their process of preparation and their therapeutical application
    10.
    发明授权
    3-Aryl 2-oxazolidinones, their process of preparation and their therapeutical application 失效
    3-芳基2-恶唑烷酮，其制备方法及其治疗应用

    公开(公告)号：US4150029A

    公开(公告)日：1979-04-17

    申请号：US771814

    申请日：1977-02-23

    申请人： Philippe L. Dostert ,  Colette A. Douzon ,  Guy R. Bourgery ,  Claude J. Gouret ,  Gisele C. Mocquet ,  Jean A. Coston

    发明人： Philippe L. Dostert ,  Colette A. Douzon ,  Guy R. Bourgery ,  Claude J. Gouret ,  Gisele C. Mocquet ,  Jean A. Coston

    IPC分类号： A61K31/42 ,  A61K31/421 ,  A61P25/24 ,  A61P25/26 ,  C07D263/24

    CPC分类号： C07D263/24

    摘要： Compounds having the formula ##STR1## wherein R.sub.1 is hydrogen or CONHR.sub.7 and R.sub.7 is methyl or isopropyl,And whereinWhen R.sub.1 is hydrogen: R is p-nitro, p-cyano; p-aldehydo; p-acetyl; m-ethyl; m-nitro; m-bromo; 3,4-dimethyl; m-NH.sub.2 ; p-methylamino; p-dimethylamino; p-diethylamino; p-methylbenzylamino; p-pyrrolidino; p-piperidino; SR.sub.4 in para position in which R.sub.4 is alkyl having 1 to 4 carbon atoms or cyclohexyl; OR.sub.5 is para position in which R.sub.5 is alkyl having 2 to 7 carbon atoms, cyclohexyl, cyclohexylmethyl, acetylmethyl; cyanomethyl, alkene-2 yl having 3 to 5 carbon atoms, butene-3 yl, cyclohexene-1 methyl, propargyl, butyne-2 yl, ##STR2## in which n is one or 2 and when n is one, R.sub.6 is hydrogen, o-fluoro, o-methyl, m-chloro, m-fluoro, m-methyl, m-trifluoromethyl, p-chloro, p-bromo-, p-fluoro, p-cyano, p-nitro or p-dimethylamino and when n is 2, R.sub.6 is hydrogen; and 3-methyl-4-benzyloxy:When R.sub.1 is CONHR.sub.7 and R.sub.7 is methyl: R is m-trifluoromethyl; m-bromo; p-chloro; p-fluoro; 3,4-dichloro; p-thiomethyl; p-acetyl; OR.sub.8 in para position wherein R.sub.8 is alkyl having 2 to 5 carbon atoms, cyanomethyl, acetylmethyl, propargyl or ##STR3## in which R.sub.9 is hydrogen, m-chloro, m-bromo, m-fluoro, p-fluoro, p-chloro or p-nitro;And when R.sub.1 is CONHR.sub.7 and R.sub.7 is isopropyl; R is m-trifluoromethyl or p-benzyloxy.The compounds are prepared by cyclizing 1-phenylamino-2,3-propandiol derivatives to form 5-hydroxymethyl-3 phenyl-2-oxozolidinone derivatives. The 5-hydroxymethyl group can be transformed to --CH.sub.2 OCONHR.sub.7 by reaction with methyl isocyanate or isopropyl isocyanate. The compounds possess psychotropic, particularly antidepressant, activity.

    摘要翻译： 具有式“IMAGE”的化合物，其中R1是氢或CONHR7，R7是甲基或异丙基，当R1是氢时，R是对硝基，对氰基; 对醛 对乙酰基; 甲基; 间硝基 溴代 3,4-二甲基 m-NH2; 对甲基氨基; 对二甲基氨基; 对二乙基氨基; 对甲基苄基氨基; 对 - 吡咯烷子; 对哌啶子 其中R4是具有1-4个碳原子的烷基的对位的SR4或环己基; OR5是R5是具有2至7个碳原子的烷基的对位，环己基，环己基甲基，乙酰基甲基; 氰基甲基，具有3至5个碳原子的烯-2，丁烯-3，环己烯-1甲基，炔丙基，丁炔-2基，其中n为1或2，当n为1时，R6为氢， 邻 - 甲基，间 - 氯，间氟，间甲基，间三氟甲基，对氯，对溴 - ，对氟，对氰基，对硝基或对二甲基氨基，当 n为2，R6为氢; 和3-甲基-4-苄氧基：