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    Anhydrous crystalline vinflunine salts, method of preparation and use thereof as a drug and means of vinflunine purification
    1.
    发明授权
    Anhydrous crystalline vinflunine salts, method of preparation and use thereof as a drug and means of vinflunine purification 有权
    无水结晶维生素盐，其制备方法及其作为药物的使用和维生素的纯化方法

    公开(公告)号：US08343991B2

    公开(公告)日：2013-01-01

    申请号：US12524898

    申请日：2008-02-13

    申请人： Jean-Louis Maurel ,  Richard Pena ,  Jean-Paul Ribet

    发明人： Jean-Louis Maurel ,  Richard Pena ,  Jean-Paul Ribet

    IPC分类号： A61K31/439 ,  C07D487/18

    CPC分类号： C07D519/04

    摘要： The present invention relates to anhydrous crystalline vinflunine salts obtained with 1 or 2 equivalents of a pharmaceutically acceptable mineral or organic acid [Acid] 1 or 2 in which [Acid] represents hydrobromic, sulfuric, lactic and fumaric acids for the group of water-soluble crystalline salts, and para-toluene sulfonic, benzoic, mandelic and para-hydroxy benzoic acids for the group of relatively insoluble crystalline salts.

    摘要翻译： 本发明涉及由1或2当量的药学上可接受的矿物或有机酸[酸] 1或2得到的无水结晶维生素盐，其中[酸]代表氢溴酸，硫酸，乳酸和富马酸，用于水溶性 结晶盐和对甲苯磺酸，苯甲酸，扁桃酸和对羟基苯甲酸用于一组相对不溶的结晶盐。

    ANHYDROUS CRYSTALLINE VINFLUNINE SALTS, METHOD OF PREPARATION AND USE THEREOF AS A DRUG AND MEANS OF VINFLUNINE PURIFICATION
    2.
    发明申请
    ANHYDROUS CRYSTALLINE VINFLUNINE SALTS, METHOD OF PREPARATION AND USE THEREOF AS A DRUG AND MEANS OF VINFLUNINE PURIFICATION 有权
    无水晶体葡萄球菌盐，其制备方法及其作为药物的使用方法和维生素纯化方法

    公开(公告)号：US20100029703A1

    公开(公告)日：2010-02-04

    申请号：US12524898

    申请日：2008-02-13

    申请人： Jean-Louis Maurel ,  Richard Pena ,  Jean-Paul Ribet

    发明人： Jean-Louis Maurel ,  Richard Pena ,  Jean-Paul Ribet

    IPC分类号： A61K31/437 ,  C07D487/16 ,  A61P35/00

    CPC分类号： C07D519/04

    摘要： The present invention relates to anhydrous crystalline vinflunine salts obtained with 1 or 2 equivalents of a pharmaceutically acceptable mineral or organic acid [Acid] 1 or 2 in which [Acid] represents hydrobromic, sulfuric, lactic and fumaric acids for the group of water-soluble crystalline salts, and para-toluene sulfonic, benzoic, mandelic and para-hydroxy benzoic acids for the group of relatively insoluble crystalline salts.

    摘要翻译： 本发明涉及由1或2当量的药学上可接受的矿物或有机酸[酸] 1或2得到的无水结晶维生素盐，其中[酸]代表氢溴酸，硫酸，乳酸和富马酸，用于水溶性 结晶盐和对甲苯磺酸，苯甲酸，扁桃酸和对羟基苯甲酸用于一组相对不溶的结晶盐。