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11 条记录 (耗时 0.037 秒)

    Cyclobutenedione compounds
    4.
    发明授权
    Cyclobutenedione compounds 失效
    环丁二酮化合物

    公开(公告)号：US06696469B2

    公开(公告)日：2004-02-24

    申请号：US09976572

    申请日：2001-10-12

    申请人： Jean-Louis Peglion ,  Jean-Paul Vilaine ,  Nicole Villeneuve ,  Catherine Thollon ,  Marie-Pierre Bourguignon ,  Christophe Poitevin

    发明人： Jean-Louis Peglion ,  Jean-Paul Vilaine ,  Nicole Villeneuve ,  Catherine Thollon ,  Marie-Pierre Bourguignon ,  Christophe Poitevin

    IPC分类号： A61K31445

    CPC分类号： C07D401/12 ,  C07D211/22 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D471/04 ,  C07D491/04

    摘要： Compounds of formula (I): wherein: X represents a heterocycle bonded to the remainder of the molecule by a nitrogen atom of the heterocycle, or an —NR2R3 group wherein R2 represents hydrogen or alkyl, and R3 represents aryl, 1,3 dihydro-2H-benzimidazolyl-2-one or alkyl substituted by a heterocycle, n represents zero or 1, R1 represents hydrogen or alkyl, Ra represents a single bond or an alkylene chain, A represents nitrogen or CH, E represents nitrogen or CRe, wherein Re is as defined in the description, Rb represents a single bond or an alkylene chain as defined in the description, W represents aryl or heteroaryl, Their optical isomers, and addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same which are useful for treatment of diseases or pathological conditions in which endothelial dysfunction is known.

    摘要翻译： 式（I）的化合物：其中：X表示通过杂环的氮原子与分子的其余部分键合的杂环，或其中R 2表示氢或烷基且R 3表示芳基的-NR 2 R 3基团， 2H-苯并咪唑基-2-酮或被杂环取代的烷基，n表示0或1，R1表示氢或烷基，Ra表示单键或亚烷基链，A表示氮或CH，E表示氮或CRe，其中Re 如说明书中所定义，R b表示如说明书中定义的单键或亚烷基链，W表示芳基或杂芳基，它们的光学异构体及其与药学上可接受的酸的加成盐，以及含有该酸的药物和含有它们的药物 用于治疗已知内皮功能障碍的疾病或病理状况。

    Piperidine-4 sulphonamide compounds
    5.
    发明授权
    Piperidine-4 sulphonamide compounds 失效
    哌啶-4-磺酰胺化合物

    公开(公告)号：US06323217B2

    公开(公告)日：2001-11-27

    申请号：US09772569

    申请日：2001-01-30

    申请人： Jean-Louis Peglion ,  Aimée Dessinges ,  Christophe Poitevin ,  Jean-Paul Vilaine ,  Nicole Villeneuve ,  Catherine Thollon ,  Marie-Pierre Bourguignon

    发明人： Jean-Louis Peglion ,  Aimée Dessinges ,  Christophe Poitevin ,  Jean-Paul Vilaine ,  Nicole Villeneuve ,  Catherine Thollon ,  Marie-Pierre Bourguignon

    IPC分类号： A61K314725

    CPC分类号： C07D401/12 ,  C07D405/06 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04

    摘要： A compound of formula (I): wherein: R1 represents hydrogen or alkyl, R2a and R2b represent a group selected from hydrogen, halogen, alkyl, hydroxy, alkoxy, trihaloalkyl, cyano, nitro, amino, alkylamino and dialkylamino, R3 represents hydrogen or hydroxy, X represents oxygen or methylene, V represents an alkylene chain that is optionally unsaturated and optionally substituted, U represents a bond or an alkylene chain, W represents a group selected from aryl and heteroaryl, each of those groups being optionally substituted by one or more identical or different groups, its isomers, its hydrates, its solvates and addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in the treatment of diseases or pathological conditions in which endothelial dysfunction is known.

    摘要翻译： 式（I）化合物：其中：R 1表示氢或烷基，R 2a和R 2b表示选自氢，卤素，烷基，羟基，烷氧基，三卤代烷基，氰基，硝基，氨基，烷基氨基和二烷基氨基的基团，R 3表示氢或 羟基，X表示氧或亚甲基，V表示任选不饱和且任选取代的亚烷基链，U表示键或亚烷基链，W表示选自芳基和杂芳基的基团，这些基团中的每一个可任选地被一个或多个 更多相同或不同的基团，其异构体，其水合物，其溶剂合物及其与药学上可接受的酸的加成盐。 含有该药物的药物可用于治疗已知内皮功能障碍的疾病或病理状况。

    1,2,4,5-tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them
    7.
    发明授权
    1,2,4,5-tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them 有权
    1,2,4,5-四氢-3H-苯并氮杂化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US08076325B2

    公开(公告)日：2011-12-13

    申请号：US12283110

    申请日：2008-09-09

    申请人： Jean-Louis Peglion ,  Bertrand Goument ,  Aimee Dessinges ,  Pascal Caignard ,  Jean-Paul Vilaine ,  Catherine Thollon ,  Nicole Villeneuve ,  Stefano Chimenti

    发明人： Jean-Louis Peglion ,  Bertrand Goument ,  Aimee Dessinges ,  Pascal Caignard ,  Jean-Paul Vilaine ,  Catherine Thollon ,  Nicole Villeneuve ,  Stefano Chimenti

    IPC分类号： A01N43/00 ,  A61K31/55 ,  C07D223/16

    CPC分类号： C07D223/16

    摘要： Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group selected from cycloalkyl, benzyl and optionally substituted alkyl, R2, R3, R4 and R5 each represent a hydrogen atom or a hydroxy, methyl, —OSO2R10, —OCOR10 or optionally substituted alkoxy group, or R2 and R3, or R3 and R4, or R4 and R5 together form a group —O—(CH2)q—O—, —O—CH═CH—O— or —O—CH═CH—, R6, R7, R8 and R9 each represent a hydrogen atom or an alkoxy group, or R6 and R7, or R7 and R8, or R8 and R9 together form a group —O—(CH2)q—O—, R10 represents a group selected from linear or branched C1-C6alkoxy, NR11R′11 and optionally substituted alkyl, R11 and R′11 each represent a hydrogen atom or an alkyl group, or R11 and R′11 together with the nitrogen atom carrying them form an optionally substituted, monocyclic or bicyclic, nitrogen-containing heterocycle, X represents O, NH or CH2, m and p each represent 0 or 1, n and q each represent 1 or 2, in racemic form or in the form of optical isomers, and also addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating various pathologies.

    摘要翻译： 式（I）化合物：其中：R 1表示氢原子或选自环烷基，苄基和任选取代的烷基的基团，R 2，R 3，R 4和R 5各自表示氢原子或羟基，甲基，-OSO 2 R 10，-OCOR 10 或任选取代的烷氧基，或R 2和R 3，或R 3和R 4，或R 4和R 5一起形成基团-O-（CH 2）q -O-，-O-CH = CH-O-或-O-CH = CH-，R6，R7，R8和R9各自表示氢原子或烷氧基，或R6和R7，或R7和R8，或R8和R9一起形成-O-（CH 2）q -O-，R 10基团 表示选自直链或支链C 1 -C 6烷氧基，NR 11 R 11和任选取代的烷基的基团，R 11和R 11各自表示氢原子或烷基，或者R 11和R 11与携带它们的氮原子一起形成 任选取代的单环或双环含氮杂环，X表示O，NH或CH 2，m和p各自表示0或1，n和q各自表示1或2，以外消旋形式或i n是光学异构体的形式，以及其与药学上可接受的酸的加成盐。 含有该药物的药物可用于治疗各种病症。

    1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them
    8.
    发明申请
    1,2,4,5-Tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them 有权
    1,2,4,5-四氢-3H-苯并氮杂化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US20090069296A1

    公开(公告)日：2009-03-12

    申请号：US12283110

    申请日：2008-09-09

    申请人： Jean-Louis Peglion ,  Bertrand Goument ,  Aimee Dessinges ,  Pascal Caignard ,  Jean-Paul Vilaine ,  Catherine Thollon ,  Nicole Villeneuve ,  Stefano Chimenti

    发明人： Jean-Louis Peglion ,  Bertrand Goument ,  Aimee Dessinges ,  Pascal Caignard ,  Jean-Paul Vilaine ,  Catherine Thollon ,  Nicole Villeneuve ,  Stefano Chimenti

    IPC分类号： C07D223/16 ,  A61K31/55

    CPC分类号： C07D223/16

    摘要： Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group selected from cycloalkyl, benzyl and optionally substituted alkyl, R2, R3, R4 and R5 each represent a hydrogen atom or a hydroxy, methyl, —OSO2R10, —OCOR10 or optionally substituted alkoxy group, or R2 and R3, or R3 and R4, or R4 and R5 together form a group —O—(CH2)q—O—, —O—CH═CH—O— or —O—CH═CH—, R6, R7, R8 and R9 each represent a hydrogen atom or an alkoxy group, or R6 and R7, or R7 and R8, or R8 and R9 together form a group —O—(CH2)q—O—-, R10 represents a group selected from linear or branched C1-C6alkoxy, NR11R′11 and optionally substituted alkyl, R11 and R′11 each represent a hydrogen atom or an alkyl group, or R11 and R′1 together with the nitrogen atom carrying them form an optionally substituted, monocyclic or bicyclic, nitrogen-containing heterocycle, X represents O, NH or CH2, m and p each represent 0 or 1, n and q each represent 1 or 2, in racemic form or in the form of optical isomers,and also addition salts thereof with a pharmaceutically acceptable acid. Medicinal products containing the same which are useful in treating various pathologies.

    摘要翻译： 式（I）化合物：其中：R 1表示氢原子或选自环烷基，苄基和任选取代的烷基的基团，R 2，R 3，R 4和R 5各自表示氢原子或羟基，甲基，-OSO 2 R 10，-OCOR 10 或任选取代的烷氧基，或R 2和R 3，或R 3和R 4或R 4和R 5一起形成基团-O-（CH 2）q O - ， - O-CH-CH-O-或-O-CH-CH- ，R6，R7，R8和R9各自表示氢原子或烷氧基，或R6和R7，或R7和R8，或R8和R9一起形成-O-（CH2）qO-基，R10表示基团 选自直链或支链C 1 -C 6烷氧基，NR 11 R 11和任选取代的烷基，R 11和R 11各自表示氢原子或烷基，或者R 11和R 11与携带它们的氮原子一起形成任选取代的， 单环或双环，含氮杂环，X表示O，NH或CH 2，m和p各自表示0或1，n和q各自表示1或2，以外消旋形式或以旋光异构体的形式， 其离子盐与药学上可接受的酸。 含有该药物的药物可用于治疗各种病症。