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公开(公告)号：US06583119B2
公开(公告)日：2003-06-24
申请号：US10162852
申请日：2002-06-05
IPC分类号： A61K3170
CPC分类号： C07H17/075
摘要： The invention relates to aromatic amides of formula wherein the various substituents are defined as set forth in the specification which have antibiotic activity.
摘要翻译： 本发明涉及各种取代基的芳族酰胺，其定义如说明书中所述，其具有抗生素活性。
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公开(公告)号：US06420538B1
公开(公告)日：2002-07-16
申请号：US09600053
申请日：2000-08-30
IPC分类号： C07H1500
CPC分类号： C07H17/075
摘要： A compound having a formula wherein the substituents are defined as in the specification and its non-toxic, pharmaceutically acceptable acid addition salts which are useful as antibiotics.
摘要翻译： 在说明书中定义具有取代基的取代基的化合物及其无毒的药学上可接受的酸加成盐，其可用作抗生素。
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3.发明授权Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments 失效由核糖取代的芳族衍生物，其制备方法及其作为药物的用途公开(公告)号：US06812331B2
公开(公告)日：2004-11-02
申请号：US09875860
申请日：2001-06-07
申请人： Michel Klich , Patrick Laurin , Branislav Musicki , Laurent Schio
发明人： Michel Klich , Patrick Laurin , Branislav Musicki , Laurent Schio
IPC分类号： C07H1700
CPC分类号： C07H15/04 , C07H17/075
摘要： A subject of the invention is the compounds of formula (I): R1═H, OH, alkyl, alkenyl or alkynyl optionally substituted or alkoxy, R2═H, Hal, R3═H, alkyl, Hal, Rg and Rh: H, alkyl, aryl heterocycle, R5═H or O-alkyl, R6═alkyl or CH2—O-alkyl, R7═H or alkyl. The compounds of formula (I) have antibiotic properties.
摘要翻译： 本发明的主题是式（I）的化合物：R1 = H，OH，烷基，烯基或炔基任选取代或烷氧基，R2 = H，Hal，R3 = H，烷基，Hal，Rg和Rh：H， 烷基，芳基杂环，R5 = H或O-烷基，R6 =烷基或CH2-O-烷基，R7 = H或烷基。式（Ⅰ）化合物具有抗生素特性。
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4.发明授权Aromatic derivatives substituted by a ribose, their method of preparation and application as medicine 失效由核糖取代的芳族衍生物，其制备方法和作为药物的应用公开(公告)号：US06350733B1
公开(公告)日：2002-02-26
申请号：US09202218
申请日：1998-12-21
申请人： Michel Klich , Patrick Laurin , Branislav Musicki , Laurent Schio
发明人： Michel Klich , Patrick Laurin , Branislav Musicki , Laurent Schio
IPC分类号： A61K3170
CPC分类号： C07H15/04 , C07H17/075
摘要： A subject of the invention is the compounds of formula (I): R1=H, OH, alkyl, alkenyl or alkynyl optionally substituted or alkoxy, R2=H, Hal, R3=H, alkyl, Hal, Rg and Rh: H, alkyl, aryl heterocycle, R5=H or O-alkyl, R6=alkyl or CH2—O-alkyl, R7=H or alkyl. The compounds of formula (I) have antibiotic properties.
摘要翻译： 本发明的主题是式（I）的化合物：R1 = H，OH，烷基，烯基或炔基任选取代或烷氧基，R2 = H，Hal，R3 = H，烷基，Hal，Rg和Rh：H， 烷基，芳基杂环，R5 = H或O-烷基，R6 =烷基或CH2-O-烷基，R7 = H或烷基。式（Ⅰ）化合物具有抗生素特性。
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5.发明授权Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors 有权杂环化合物，它们的制备及其作为药物的用途，特别是作为抗菌剂和β-内酰胺酶抑制剂公开(公告)号：US07439253B2
公开(公告)日：2008-10-21
申请号：US10727911
申请日：2003-12-04
IPC分类号： A61P31/00 , A61K31/44 , C07D471/00
CPC分类号： C07D471/08
摘要： The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a method for preparing these compounds, and to their use as medicaments, in particular as antibacterials and β-lactamase inhibitors.
摘要翻译： 本发明涉及通式（I）的新型杂环化合物及其与碱或酸的盐：本发明还涉及一种制备这些化合物的方法及其作为药物的用途，特别是作为抗菌剂和β- 内酰胺酶抑制剂。
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6.发明申请NOVEL HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTIBACTERIALS AND BETA-LACTAMASE INHIBITORS 审中-公开新型杂环化合物，其制备及其作为药物，特别是作为抗菌素和β-谷甾醇酶抑制剂的用途公开(公告)号：US20090018329A1
公开(公告)日：2009-01-15
申请号：US12211509
申请日：2008-09-16
IPC分类号： C07D487/04
CPC分类号： C07D471/08
摘要： The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a method for preparing these compounds, and to their use as medicaments, in particular as antibacterials and β-lactamase inhibitors.
摘要翻译： 本发明涉及通式（I）的新型杂环化合物及其与碱或酸的盐：本发明还涉及一种制备这些化合物的方法及其作为药物的用途，特别是作为抗菌剂和β- 内酰胺酶抑制剂。
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7.发明授权Ribose-substituted aromatic amides, method for the production and use thereof as medicaments 失效核糖取代的芳族酰胺，其生产和使用方法作为药物公开(公告)号：US06579902B1
公开(公告)日：2003-06-17
申请号：US09980728
申请日：2002-01-09
IPC分类号： A61K3135
CPC分类号： C07H17/075
摘要： Compounds of formula (I); wherein R1=alkyl, alkenyl or alkynyl, O-alkyl, O-alkenyl or optionally substituted, optionally interrupted O-alkynyl; R2=hydrogen or halogen; R3=hydrogen, alkyl or halogen; R4=NHR′ or NHOR″, R′ or R″ are identical or different and represent hydrogen, alkyl, alkenyl or alkynyl, aryl; R5=hydrogen or O-alkyl; R6=alkyl or CH2—O-alkyl; R7=hydrogen or alkyl or R6 et R7 form a cycle together with the carbon carrying them in addition to the addition salts thereof with bases. The compounds of formula (I) have antibiotic properties.
摘要翻译： 式（I）化合物; 其中R 1 =烷基，烯基或炔基，O-烷基，O-烯基或任选取代的任选中断的O-炔基; R2 =氢或卤素; R3 =氢，烷基或卤素; R4 = NHR'或NHOR“，R'或R”相同或不同，表示氢，烷基，烯基或炔基，芳基; R5 =氢或O-烷基; R6 =烷基或CH2-O-烷基; R7 =氢或烷基或R6和R7与携带它们的碳以及与碱的加成盐一起形成一个循环。 式（I）化合物具有抗生素特性。
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8.发明授权Heterocyclic compounds, preparation process and intermediates, and use as medicaments, in particular as β-lactamase inhibitors and antibacterials 失效杂环化合物，制备方法和中间体，并用作药物，特别是作为β-内酰胺酶抑制剂和抗菌剂公开(公告)号：US07365071B2
公开(公告)日：2008-04-29
申请号：US10655364
申请日：2003-09-04
申请人： Branislav Musicki
发明人： Branislav Musicki
IPC分类号： A61P31/00 , A61K31/4995 , C07D237/28 , C07D243/02 , C07D487/08 , C07D235/00
CPC分类号： C07D487/08 , C07D237/28 , C07D243/02
摘要： The invention relates to novel heterocyclic compounds of general formula (I) and to their salts with a base or an acid: The invention also relates to processes and to intermediates for the preparation of these compounds, and to their use as medicaments, in particular as antibacterials and β-lactamase inhibitors.
摘要翻译： 本发明涉及通式（I）的新型杂环化合物及其与碱或酸的盐：本发明还涉及制备这些化合物的方法和中间体，以及它们作为药物的用途，特别是作为 抗菌剂和β-内酰胺酶抑制剂。
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9.发明授权公开(公告)号：US07288549B2
公开(公告)日：2007-10-30
申请号：US10480019
申请日：2002-06-04
IPC分类号： A61P31/04 , A61K31/44 , C07D471/08
CPC分类号： C07D215/38 , C07D217/22 , C07D217/26 , C07D471/04 , C07D471/08 , C07D491/04 , C07D495/04 , C07D513/04 , Y02P20/55
摘要： The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds, as well as their use as medicaments, in particular as anti-bacterial agents.
摘要翻译： 本发明涉及新的通式（I）杂环化合物及其与碱或酸的盐：本发明还涉及制备这些化合物的方法，以及它们作为药物的用途，特别是作为抗 细菌剂。
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10.发明申请NOVEL HETEROCYCLIC COMPOUNDS, PREPARATION PROCESS AND INTERMEDIATES, AND USE AS MEDICAMENTS, IN PARTICULAR AS BETA-LACTAMASE INHIBITORS AND ANTIBACTERIALS 审中-公开新型杂环化合物，制备方法和中间体，作为药物，特别是作为β-乳糖酶抑制剂和抗生素的药物公开(公告)号：US20070191312A1
公开(公告)日：2007-08-16
申请号：US11734608
申请日：2007-04-12
申请人： Branislav Musicki
发明人： Branislav Musicki
IPC分类号： A61K31/675
CPC分类号： C07D487/08 , C07D237/28 , C07D243/02
摘要： The invention relates to novel heterocyclic compounds of general formula (I) and to their salts with a base or an acid: The invention also relates to processes and to intermediates for the preparation of these compounds, and to their use as medicaments, in particular as antibacterials and β-lactamase inhibitors.
摘要翻译： 本发明涉及通式（I）的新型杂环化合物及其与碱或酸的盐：本发明还涉及制备这些化合物的方法和中间体，以及它们作为药物的用途，特别是作为 抗菌剂和β-内酰胺酶抑制剂。
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