公开(公告)号：US5814305A

公开(公告)日：1998-09-29

申请号：US381583

申请日：1995-01-30

申请人： Jean-Pierre Laugier ,  Marie-France Rude ,  Philippe Touzan ,  Fran.cedilla.ois Rigenbach

发明人： Jean-Pierre Laugier ,  Marie-France Rude ,  Philippe Touzan ,  Fran.cedilla.ois Rigenbach

IPC分类号： A61K9/08 ,  A61K8/33 ,  A61K8/41 ,  A61K31/045 ,  A61K31/135 ,  A61K31/137 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22 ,  A61K47/34 ,  A61P17/00 ,  A61P31/10 ,  A61Q3/00 ,  A61K7/04 ,  A61K7/043

CPC分类号： A61Q3/00 ,  A61K31/135 ,  A61K31/137 ,  A61K47/10 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22 ,  A61K8/33 ,  A61K8/41 ,  A61K9/0014 ,  Y10S514/858 ,  Y10S514/947

摘要： The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at least one antifungal agent chosen, in particular, from among those of the allylamine family, such as terbinafine-HCl and naftifine-HCl; at least one hydrophilic penetration agent chosen, in particular, from among the glycols, glycol monoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, ethyl lactate, the polyoxyethylenated C.sub.8 -C.sub.10 glycerides, polyethylene glycol 20 glyceryl laurate and dimethylacetamide; and a water-alcohol solvent medium which dissolves the said antifungal agent(s) and in which the said penetration agent(s) is (or are) at least partially miscible.