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公开(公告)号：US08940544B2
公开(公告)日：2015-01-27
申请号：US13022494
申请日：2011-02-07
CPC分类号： G01N21/6428 , G01N21/6408 , G01N21/77 , G01N2021/6432 , G01N2021/6484 , G01N2021/773 , G01N2021/7786
摘要： Analyte sensors having antioxidant protection are disclosed. By combining antioxidant and/or scavenger agents into polymer matrices that contain sensor moieties, the sensor moieties are protected from reactive oxygen species. Also disclosed are methods of making analyte sensors and methods of inhibiting oxidative degradation of sensing components in hydrated, polymerized analyte sensor systems.
摘要翻译： 公开了具有抗氧化保护作用的分析物传感器。 通过将抗氧化剂和/或清除剂结合到含有传感器部分的聚合物基质中，传感器部分被保护免受活性氧。 还公开了制备分析物传感器的方法和在水合的聚合分析物传感器系统中抑制感测组分的氧化降解的方法。
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公开(公告)号：US08178676B2
公开(公告)日：2012-05-15
申请号：US13069150
申请日：2011-03-22
申请人： Soya Gamsey , Ritchie A. Wessling
发明人： Soya Gamsey , Ritchie A. Wessling
CPC分类号： G01N33/523 , C07F5/025 , G01N2400/00
摘要： Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.
摘要翻译： 公开了用硼酸官能化的新型吡啶鎓盐及其制备方法。 当与荧光染料组合时，该化合物可用于检测多羟基取代的有机分子。
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公开(公告)号：US08658795B2
公开(公告)日：2014-02-25
申请号：US13456059
申请日：2012-04-25
申请人： Soya Gamsey , Ritchie A. Wessling
发明人： Soya Gamsey , Ritchie A. Wessling
CPC分类号： G01N33/523 , C07F5/025 , G01N2400/00
摘要： Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.
摘要翻译： 公开了用硼酸官能化的新型吡啶鎓盐及其制备方法。 当与荧光染料组合时，该化合物可用于检测多羟基取代的有机分子。
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公开(公告)号：US07939664B2
公开(公告)日：2011-05-10
申请号：US12113876
申请日：2008-05-01
申请人： Soya Gamsey , Ritchie A. Wessling
发明人： Soya Gamsey , Ritchie A. Wessling
CPC分类号： G01N33/523 , C07F5/025 , G01N2400/00
摘要： Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.
摘要翻译： 公开了用硼酸官能化的新型吡啶鎓盐及其制备方法。 当与荧光染料组合时，该化合物可用于检测多羟基取代的有机分子。
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公开(公告)号：US07829341B2
公开(公告)日：2010-11-09
申请号：US12172059
申请日：2008-07-11
申请人： Soya Gamsey , Ritchie A. Wessling
发明人： Soya Gamsey , Ritchie A. Wessling
IPC分类号： G01N33/52 , G01N33/66 , G01N21/64 , C07D213/22 , C07F5/02
CPC分类号： C07F5/025 , C08G73/0627 , C09K9/02 , C09K2211/1029 , Y10T436/143333 , Y10T436/144444
摘要： The invention relates to a class of glucose-responsive, polyviologen boronic acid quenchers that may be used in combination with fluophores to achieve real-time measurement of glucose levels in vivo.
摘要翻译： 本发明涉及可与荧光团组合使用的一类葡萄糖反应型聚io烯硼酸猝灭剂，以实现体内葡萄糖水平的实时测量。
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6.发明申请POLYVIOLOGEN BORONIC ACID QUENCHERS FOR USE IN ANALYTE SENSORS 有权用于分析仪传感器的POLYVIOLOGEN BORONIC ACID QUENCHERS公开(公告)号：US20090081803A1
公开(公告)日：2009-03-26
申请号：US12172059
申请日：2008-07-11
申请人： Soya Gamsey , Ritchie A. Wessling
发明人： Soya Gamsey , Ritchie A. Wessling
CPC分类号： C07F5/025 , C08G73/0627 , C09K9/02 , C09K2211/1029 , Y10T436/143333 , Y10T436/144444
摘要： The invention relates to a class of glucose-responsive, polyviologen boronic acid quenchers that may be used in combination with fluophores to achieve real-time measurement of glucose levels in vivo.
摘要翻译： 本发明涉及可与荧光团组合使用的一类葡萄糖反应型聚io烯硼酸猝灭剂，以实现体内葡萄糖水平的实时测量。
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公开(公告)号：US20080305009A1
公开(公告)日：2008-12-11
申请号：US12113876
申请日：2008-05-01
申请人： Soya Gamsey , Ritchie A. Wessling
发明人： Soya Gamsey , Ritchie A. Wessling
IPC分类号： G01N21/64 , C07F5/02 , C08F126/08 , C08F128/02 , C08F120/06
CPC分类号： G01N33/523 , C07F5/025 , G01N2400/00
摘要： Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.
摘要翻译： 公开了用硼酸官能化的新型吡啶鎓盐及其制备方法。 当与荧光染料组合时，该化合物可用于检测多羟基取代的有机分子。
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公开(公告)号：US20100274110A1
公开(公告)日：2010-10-28
申请号：US12830231
申请日：2010-07-02
IPC分类号： A61B5/1459 , G01N33/52 , G01N21/64
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14539 , A61B5/1459 , G01N33/66 , G01N33/84 , G01N2400/00
摘要： Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.
摘要翻译： 本发明的实施例涉及一种能够与单个指示器系统同时测量两种分析物的光学传感器。 在优选的实施方案中，传感器包括具有促进比例pH感测的酸和碱形式的荧光染料，其中染料进一步与葡萄糖结合部分相关联并且被配置为产生随葡萄糖浓度而变化的信号。
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公开(公告)号：US20080188722A1
公开(公告)日：2008-08-07
申请号：US11671880
申请日：2007-02-06
IPC分类号： A61B5/1455 , G01N21/64
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14539 , A61B5/1459 , G01N33/66 , G01N33/84 , G01N2400/00
摘要： Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.
摘要翻译： 本发明的实施例涉及一种能够与单个指示器系统同时测量两种分析物的光学传感器。 在优选的实施方案中，传感器包括具有促进比例pH感测的酸和碱形式的荧光染料，其中染料进一步与葡萄糖结合部分相关联并且被配置为产生随葡萄糖浓度而变化的信号。
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公开(公告)号：US07751863B2
公开(公告)日：2010-07-06
申请号：US11671880
申请日：2007-02-06
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14539 , A61B5/1459 , G01N33/66 , G01N33/84 , G01N2400/00
摘要： Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.
摘要翻译： 本发明的实施例涉及一种能够与单个指示器系统同时测量两种分析物的光学传感器。 在优选的实施方案中，传感器包括具有促进比例pH感测的酸和碱形式的荧光染料，其中染料进一步与葡萄糖结合部分相关联并且被配置为产生随葡萄糖浓度而变化的信号。
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