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公开(公告)号：US20100274110A1
公开(公告)日：2010-10-28
申请号：US12830231
申请日：2010-07-02
IPC分类号： A61B5/1459 , G01N33/52 , G01N21/64
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14539 , A61B5/1459 , G01N33/66 , G01N33/84 , G01N2400/00
摘要： Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.
摘要翻译： 本发明的实施例涉及一种能够与单个指示器系统同时测量两种分析物的光学传感器。 在优选的实施方案中，传感器包括具有促进比例pH感测的酸和碱形式的荧光染料，其中染料进一步与葡萄糖结合部分相关联并且被配置为产生随葡萄糖浓度而变化的信号。
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公开(公告)号：US20080188722A1
公开(公告)日：2008-08-07
申请号：US11671880
申请日：2007-02-06
IPC分类号： A61B5/1455 , G01N21/64
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14539 , A61B5/1459 , G01N33/66 , G01N33/84 , G01N2400/00
摘要： Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.
摘要翻译： 本发明的实施例涉及一种能够与单个指示器系统同时测量两种分析物的光学传感器。 在优选的实施方案中，传感器包括具有促进比例pH感测的酸和碱形式的荧光染料，其中染料进一步与葡萄糖结合部分相关联并且被配置为产生随葡萄糖浓度而变化的信号。
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公开(公告)号：US07751863B2
公开(公告)日：2010-07-06
申请号：US11671880
申请日：2007-02-06
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14539 , A61B5/1459 , G01N33/66 , G01N33/84 , G01N2400/00
摘要： Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.
摘要翻译： 本发明的实施例涉及一种能够与单个指示器系统同时测量两种分析物的光学传感器。 在优选的实施方案中，传感器包括具有促进比例pH感测的酸和碱形式的荧光染料，其中染料进一步与葡萄糖结合部分相关联并且被配置为产生随葡萄糖浓度而变化的信号。
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4.发明授权Method for polymerizing a monomer solution within a cavity to generate a smooth polymer surface 有权在空腔内聚合单体溶液以产生光滑聚合物表面的方法公开(公告)号：US08110251B2
公开(公告)日：2012-02-07
申请号：US12026396
申请日：2008-02-05
IPC分类号： B05D3/10
CPC分类号： G01N21/7703 , G01N2021/6434 , G01N2021/773 , G01N2021/7786
摘要： In preferred embodiments, the present invention relates to methods for polymerizing a monomer solution within a cavity covered by a porous membrane to generate a smooth polymer surface. More specifically, the method can be used to provide a medical device or sensor with a smooth polymer surface.
摘要翻译： 在优选的实施方案中，本发明涉及在由多孔膜覆盖的空腔内聚合单体溶液以产生光滑聚合物表面的方法。 更具体地，该方法可用于提供具有光滑聚合物表面的医疗装置或传感器。
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5.发明申请METHOD FOR POLYMERIZING A MONOMER SOLUTION WITHIN A CAVITY TO GENERATE A SMOOTH POLYMER SURFACE 有权用于在孔中聚合单体溶液以生成平滑聚合物表面的方法公开(公告)号：US20080187655A1
公开(公告)日：2008-08-07
申请号：US12026396
申请日：2008-02-05
CPC分类号： G01N21/7703 , G01N2021/6434 , G01N2021/773 , G01N2021/7786
摘要： In preferred embodiments, the present invention relates to methods for polymerizing a monomer solution within a cavity covered by a porous membrane to generate a smooth polymer surface. More specifically, the method can be used to provide a medical device or sensor with a smooth polymer surface.
摘要翻译： 在优选的实施方案中，本发明涉及在由多孔膜覆盖的空腔内聚合单体溶液以产生光滑聚合物表面的方法。 更具体地，该方法可用于提供具有光滑聚合物表面的医疗装置或传感器。
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6.发明申请METHOD FOR POLYMERIZING A MONOMER SOLUTION WITHIN A CAVITY TO GENERATE A SMOOTH POLYMER SURFACE 审中-公开用于在孔中聚合单体溶液以生成平滑聚合物表面的方法公开(公告)号：US20120282412A1
公开(公告)日：2012-11-08
申请号：US13343584
申请日：2012-01-04
CPC分类号： G01N21/7703 , G01N2021/6434 , G01N2021/773 , G01N2021/7786
摘要： In preferred embodiments, the present invention relates to methods for polymerizing a monomer solution within a cavity covered by a porous membrane to generate a smooth polymer surface. More specifically, the method can be used to provide a medical device or sensor with a smooth polymer surface.
摘要翻译： 在优选的实施方案中，本发明涉及在由多孔膜覆盖的空腔内聚合单体溶液以产生光滑聚合物表面的方法。 更具体地，该方法可用于提供具有光滑聚合物表面的医疗装置或传感器。
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7.发明授权Optical systems and methods for ratiometric measurement of blood glucose concentration 有权用于血糖浓度比例测量的光学系统和方法公开(公告)号：US08838195B2
公开(公告)日：2014-09-16
申请号：US12027158
申请日：2008-02-06
IPC分类号： A61B5/1455 , G01N21/64 , A61B5/1459 , A61B5/145
CPC分类号： A61B5/14532 , A61B5/0071 , A61B5/14552 , A61B5/1459 , A61B5/7203 , G01N21/6428 , G01N21/645
摘要： Novel optical devices, methods and systems relating to the detection of glucose, and more particularly to real-time glucose monitoring, are disclosed herein. More particularly, various hardware and methodological means are disclosed for ratiometric correction of optical glucose measurements for artifacts of optical systems.
摘要翻译： 本文公开了与葡萄糖检测有关的新型光学器件，方法和系统，更具体地涉及实时葡萄糖监测。 更具体地，公开了用于光学系统的伪像的光学葡萄糖测量的比例校正的各种硬件和方法手段。
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公开(公告)号：US08972196B2
公开(公告)日：2015-03-03
申请号：US12794466
申请日：2010-06-04
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1455 , G01N21/6428 , G01N21/6486 , G01N31/22 , G01N33/52 , G01N33/582 , G01N2021/6432 , G01N2201/062 , G01N2201/127
摘要： Disclosed are embodiments that relate to algorithms and methods for calibrating an analyte sensor, and more particularly, to algorithms for calibrating an optical glucose sensor comprising an equilibrium fluorescent chemical indicator system. In particular, a method of detecting an analyte concentration is disclosed where a modified Michaelis-Menten equation comprising Michaelis-Menten parameters is used to characterize the signal generated by the analyte sensor.
摘要翻译： 公开了涉及用于校准分析物传感器的算法和方法的实施例，更具体地，涉及用于校准包括平衡荧光化学指示器系统的光学葡萄糖传感器的算法。 特别地，公开了一种检测分析物浓度的方法，其中使用包含Michaelis-Menten参数的修改的Michaelis-Menten方程表征由分析物传感器产生的信号。
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公开(公告)号：US20110077477A1
公开(公告)日：2011-03-31
申请号：US12895394
申请日：2010-09-30
申请人： Matthew A. Romey , Soya Gamsey , David R. Markle
发明人： Matthew A. Romey , Soya Gamsey , David R. Markle
IPC分类号： A61B5/1473 , A61L33/00 , G01N21/00
CPC分类号： A61B5/14532 , A61B5/14539 , A61B5/14542 , A61B5/1459 , G01N21/7703 , G01N21/80 , G01N2021/773 , G01N2021/7786
摘要： Embodiments of the present invention relate to analyte sensors comprising a heparin benzalkonium antithrombogenic coating, and methods of coating analyte sensors.
摘要翻译： 本发明的实施方案涉及包含肝素苯扎氯铵抗凝血酶涂层的分析物传感器以及涂覆分析物传感器的方法。
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10.发明申请公开(公告)号：US20110152658A1
公开(公告)日：2011-06-23
申请号：US12972385
申请日：2010-12-17
IPC分类号： A61B5/145
CPC分类号： A61B5/1473 , A61B5/01 , A61B5/14532 , A61B5/1495 , A61B5/7239 , A61B2560/0252 , A61B2562/0271
摘要： Disclosed herein are methods and systems for generating an estimate of an in vivo analyte concentration and identifying whether the estimate is aberrant. In some embodiments, the system includes a sensor comprising an analyte sensor and a temperature sensing element, and a control unit programmed to identify changes in temperature that may indicate a non-physiologic condition (and result in an aberrant glucose measurement). In some embodiments, the methods include generating an estimate of analyte concentration at a particular time using the analyte sensor, and generating first and second signals indicative of temperature using the temperature sensing element. In some embodiments the methods include identifying the estimate of analyte concentration as aberrant if the magnitude of the difference between the first and second signals indicative of temperature exceeds a threshold value.
摘要翻译： 本文公开了用于产生体内分析物浓度的估计并识别估计是否异常的方法和系统。 在一些实施例中，系统包括传感器，其包括分析物传感器和温度感测元件，以及控制单元，被编程为识别可能指示非生理状况（并导致异常葡萄糖测量）的温度变化。 在一些实施方案中，所述方法包括使用分析物传感器在特定时间产生分析物浓度的估计，以及使用温度感测元件产生指示温度的第一和第二信号。 在一些实施方案中，如果指示温度的第一和第二信号之间的差值的大小超过阈值，则所述方法包括将分析物浓度的估计识别为异常。
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