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公开(公告)号：US20080008714A1
公开(公告)日：2008-01-10
申请号：US11725870
申请日：2007-03-20
IPC分类号： A61K39/395 , A61K38/16 , A61P35/00 , A61P43/00
CPC分类号： C07K16/2878 , A61K38/00 , C07K2317/73
摘要： The present invention relates to methods of modulating angiogenesis and inhibiting tumor progression by using TWEAK receptor (Fn14) agonists. In particular, methods for inhibiting angiogenesis are disclosed.
摘要翻译： 本发明涉及通过使用TWEAK受体（Fn14）激动剂调节血管发生和抑制肿瘤进展的方法。 特别地，公开了抑制血管发生的方法。
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公开(公告)号：US20110002924A1
公开(公告)日：2011-01-06
申请号：US12756078
申请日：2010-04-07
IPC分类号： A61K39/395 , A61P35/00 , A61P9/00
CPC分类号： C07K16/2878 , A61K38/00 , C07K2317/73
摘要： The present invention relates to methods of modulating angiogenesis and inhibiting tumor progression by using TWEAK receptor (Fn14) agonists. In particular, methods for inhibiting angiogenesis are disclosed.
摘要翻译： 本发明涉及通过使用TWEAK受体（Fn14）激动剂调节血管发生和抑制肿瘤进展的方法。 特别地，公开了抑制血管发生的方法。
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公开(公告)号：US07731963B2
公开(公告)日：2010-06-08
申请号：US11725870
申请日：2007-03-20
IPC分类号： A61K39/395
CPC分类号： C07K16/2878 , A61K38/00 , C07K2317/73
摘要： The present invention relates to methods of modulating angiogenesis and inhibiting tumor progression by using TWEAK receptor (Fn14) agonists. In particular, methods for inhibiting angiogenesis are disclosed.
摘要翻译： 本发明涉及通过使用TWEAK受体（Fn14）激动剂调节血管发生和抑制肿瘤进展的方法。 特别地，公开了抑制血管发生的方法。
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公开(公告)号：US07208151B2
公开(公告)日：2007-04-24
申请号：US10380611
申请日：2001-09-12
IPC分类号： A61K39/395
CPC分类号： C07K16/2878 , A61K38/00 , C07K2317/73
摘要： The present invention relates to methods of modulating angiogenesis and inhibiting tumor progression by using TWEAK receptor (Fn14) agonists. In particular, methods for inhibiting angiogenesis are disclosed.
摘要翻译： 本发明涉及通过使用TWEAK受体（Fn14）激动剂调节血管发生和抑制肿瘤进展的方法。 特别地，公开了抑制血管发生的方法。
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公开(公告)号：US20060240004A1
公开(公告)日：2006-10-26
申请号：US10510804
申请日：2003-04-09
申请人： Linda Burkly , Aniela Jakubowski , Timothy Zheng , Kyungmin Hahm
发明人： Linda Burkly , Aniela Jakubowski , Timothy Zheng , Kyungmin Hahm
IPC分类号： A61K49/00 , A61K39/395 , A61K38/17
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
摘要翻译： 本发明提供了治疗TWEAK相关病症的方法和试剂，包括心脏，肝脏，肾脏，肺，脂肪，骨骼，肌肉，神经元，骨骼和软骨条件。 本发明还提供用于鉴定用于治疗TWEAK相关病症的TWEAK激动剂或拮抗剂的方法。 另外，本发明提供表达编码TWEAK多肽或其片段，类似物或突变蛋白的外源DNA的转基因动物，以及使用这些动物鉴定TWEAK激动剂或拮抗剂的方法。 本发明还提供了基于TWEAK表达来诊断疾病的方法。 本发明还提供了使用TWEAK多肽，激动剂或拮抗剂来影响祖细胞的细胞分化的方法。
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公开(公告)号：US20060003932A1
公开(公告)日：2006-01-05
申请号：US11145340
申请日：2005-06-02
申请人： Aniela Jakubowski , Linda Burkly
发明人： Aniela Jakubowski , Linda Burkly
IPC分类号： A61K38/18
CPC分类号： C12N5/069 , A61K38/177 , A61K38/1825 , A61K45/06 , C12N2501/115 , C12N2501/165 , C12N2501/25 , C12N2501/998 , A61K2300/00
摘要： The present invention relates to a method for enhancing angiogenic activity to promote neovascularization comprising administering to a subject a formulation comprising a synergistically effective amount of a TWEAK agonist and an angiogenic factor.
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公开(公告)号：US06943146B2
公开(公告)日：2005-09-13
申请号：US10275997
申请日：2001-05-07
申请人： Aniela Jakubowski , Linda Burkly
发明人： Aniela Jakubowski , Linda Burkly
IPC分类号： A61K38/18 , A61K38/19 , A61K38/22 , A61K45/00 , A61K45/06 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/14 , A61P17/02 , A61P41/00 , A61P43/00 , C12N5/071
CPC分类号： C12N5/069 , A61K38/177 , A61K38/1825 , A61K45/06 , C12N2501/115 , C12N2501/165 , C12N2501/25 , C12N2501/998 , A61K2300/00
摘要： The present invention relates to a method for enhancing angiogenic activity to promote neovascularization comprising administering to a subject a formulation comprising a synergistically effective amount of a TWEAK agonist and an angiogenic factor.
摘要翻译： 本发明涉及一种用于增强血管生成活性以促进新血管形成的方法，包括向受试者施用包含协同有效量的TWEAK激动剂和血管发生因子的制剂。
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公开(公告)号：US20130216496A1
公开(公告)日：2013-08-22
申请号：US13860983
申请日：2013-04-11
IPC分类号： C07K16/24 , C07K16/22 , C07K14/525
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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公开(公告)号：US08506958B2
公开(公告)日：2013-08-13
申请号：US12417755
申请日：2009-04-03
IPC分类号： A61K39/395 , C07K16/22 , C07K16/46
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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公开(公告)号：US20120015024A1
公开(公告)日：2012-01-19
申请号：US13179096
申请日：2011-07-08
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
摘要翻译： 本发明提供了治疗TWEAK相关病症的方法和试剂，包括心脏，肝脏，肾脏，肺，脂肪，骨骼，肌肉，神经元，骨骼和软骨条件。 本发明还提供用于鉴定用于治疗TWEAK相关病症的TWEAK激动剂或拮抗剂的方法。 另外，本发明提供表达编码TWEAK多肽或其片段，类似物或突变蛋白的外源DNA的转基因动物，以及使用这些动物鉴定TWEAK激动剂或拮抗剂的方法。 本发明还提供了基于TWEAK表达来诊断疾病的方法。 本发明还提供了使用TWEAK多肽，激动剂或拮抗剂来影响祖细胞的细胞分化的方法。
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