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公开(公告)号：US08506958B2
公开(公告)日：2013-08-13
申请号：US12417755
申请日：2009-04-03
IPC分类号： A61K39/395 , C07K16/22 , C07K16/46
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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公开(公告)号：US20120015024A1
公开(公告)日：2012-01-19
申请号：US13179096
申请日：2011-07-08
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
摘要翻译： 本发明提供了治疗TWEAK相关病症的方法和试剂，包括心脏，肝脏，肾脏，肺，脂肪，骨骼，肌肉，神经元，骨骼和软骨条件。 本发明还提供用于鉴定用于治疗TWEAK相关病症的TWEAK激动剂或拮抗剂的方法。 另外，本发明提供表达编码TWEAK多肽或其片段，类似物或突变蛋白的外源DNA的转基因动物，以及使用这些动物鉴定TWEAK激动剂或拮抗剂的方法。 本发明还提供了基于TWEAK表达来诊断疾病的方法。 本发明还提供了使用TWEAK多肽，激动剂或拮抗剂来影响祖细胞的细胞分化的方法。
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公开(公告)号：US20130216496A1
公开(公告)日：2013-08-22
申请号：US13860983
申请日：2013-04-11
IPC分类号： C07K16/24 , C07K16/22 , C07K14/525
CPC分类号： C07K16/241 , A01K2217/05 , A61K38/00 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K14/70575 , C07K16/22 , C07K16/2875 , C07K2319/00 , C07K2319/30
摘要： The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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公开(公告)号：US20090124993A1
公开(公告)日：2009-05-14
申请号：US11816502
申请日：2006-02-17
申请人： Linda C. Burkly , Kyungmin Hahm , Timothy Zheng , Steve Perrin , John Lincecum
发明人： Linda C. Burkly , Kyungmin Hahm , Timothy Zheng , Steve Perrin , John Lincecum
CPC分类号： A61K39/3955 , A61K38/1793 , G01N33/6896 , G01N2800/2814 , G01N2800/2835
摘要： Methods of treating neuronal disorders, such as mechanical neuronal traumas and neurodegenerative disorders, with TWEAK or TWEAK-R blocking agents are presented.
摘要翻译： 提出用TWEAK或TWEAK-R阻断剂治疗神经元疾病如机械神经元创伤和神经退行性疾病的方法。
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公开(公告)号：US20120183542A1
公开(公告)日：2012-07-19
申请号：US13222097
申请日：2011-08-31
申请人： Linda C. Burkly , Kyungmin Hahm , Timothy Zheng , Steve Perrin , John Lincecum
发明人： Linda C. Burkly , Kyungmin Hahm , Timothy Zheng , Steve Perrin , John Lincecum
IPC分类号： A61K39/395 , A61P25/00 , A61P29/00 , C07K16/24 , C07K16/28
CPC分类号： A61K39/3955 , A61K38/1793 , G01N33/6896 , G01N2800/2814 , G01N2800/2835
摘要： Methods of treating neuronal disorders, such as mechanical neuronal traumas and neurodegenerative disorders, with TWEAK or a TWEAK receptor blocking agents are presented.
摘要翻译： 提出用TWEAK或TWEAK受体阻断剂治疗神经元疾病如机械神经元创伤和神经变性疾病的方法。
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公开(公告)号：US20090068102A1
公开(公告)日：2009-03-12
申请号：US11816500
申请日：2006-02-15
申请人： Linda C. Burkly , Kyungmin Hahm , Marcus Schwaninger , Ionta Inta
发明人： Linda C. Burkly , Kyungmin Hahm , Marcus Schwaninger , Ionta Inta
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/76 , C07K2319/30
摘要： Methods of treating stroke with blocking agents of TWEAK or TWEAK receptor are presented.
摘要翻译： 提出了用TWEAK或TWEAK受体阻断剂治疗中风的方法。
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公开(公告)号：US08728475B2
公开(公告)日：2014-05-20
申请号：US13246197
申请日：2011-09-27
申请人： Linda C. Burkly , Timothy Zheng
发明人： Linda C. Burkly , Timothy Zheng
IPC分类号： A61K39/395 , A61K38/16 , A61K38/17
CPC分类号： A61K45/06 , A61K38/177 , A61K38/1793 , A61K39/39541 , A61K2039/505 , C07K16/2875 , C07K2317/56 , G01N2800/102 , A61K2300/00
摘要： Methods of treating inflammatory disorders, such as rheumatoid arthritis, by modulating TWEAK and TNF-α are disclosed, as are other methods.
摘要翻译： 公开了通过调节TWEAK和TNF-α来治疗炎症性疾病如类风湿性关节炎的方法，以及其它方法。
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公开(公告)号：US20120014953A1
公开(公告)日：2012-01-19
申请号：US13246197
申请日：2011-09-27
申请人： Linda C. Burkly , Timothy Zheng
发明人： Linda C. Burkly , Timothy Zheng
IPC分类号： A61K39/395 , A61P19/02 , A61P29/00 , A61K38/16
CPC分类号： A61K45/06 , A61K38/177 , A61K38/1793 , A61K39/39541 , A61K2039/505 , C07K16/2875 , C07K2317/56 , G01N2800/102 , A61K2300/00
摘要： Methods of treating inflammatory disorders, such as rheumatoid arthritis, by modulating TWEAK and TNF-α are disclosed, as are other methods.
摘要翻译： 公开了通过调节TWEAK和TNF-α来治疗炎症性疾病如类风湿性关节炎的方法，以及其它方法。
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公开(公告)号：US20080187544A1
公开(公告)日：2008-08-07
申请号：US11937687
申请日：2007-11-09
申请人： Linda C. Burkly , Timothy Zheng
发明人： Linda C. Burkly , Timothy Zheng
IPC分类号： A61K39/395 , A61K39/44 , C12Q1/02 , A61K31/519 , A61K33/24 , A61K31/44 , A61K31/47 , A61P19/02 , A61P29/00
CPC分类号： A61K45/06 , A61K38/177 , A61K38/1793 , A61K39/39541 , A61K2039/505 , C07K16/2875 , C07K2317/56 , G01N2800/102 , A61K2300/00
摘要： Methods of treating inflammatory disorders, such as rheumatoid arthritis, by modulating TWEAK and TNF-α are disclosed, as are other methods.
摘要翻译： 公开了通过调节TWEAK和TNF-α来治疗炎症性疾病如类风湿性关节炎的方法，以及其它方法。
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10.发明授权Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind CD154 and uses thereof 有权结合蛋白质，包括特异性结合CD154的抗体，抗体衍生物和抗体片段及其用途公开(公告)号：US08293237B2
公开(公告)日：2012-10-23
申请号：US12532517
申请日：2008-03-21
申请人： Linda C. Burkly , Janine L. Ferrant-Orgettas , Ellen A. Garber , Yen-Ming Hsu , Lihe Su , Frederick R. Taylor , Ralph Adams , Derek Thomas Brown , Andrew George Popplewell , Martyn Kim Robinson , Anthony Shock , Kerry Louise Tyson
发明人： Linda C. Burkly , Janine L. Ferrant-Orgettas , Ellen A. Garber , Yen-Ming Hsu , Lihe Su , Frederick R. Taylor , Ralph Adams , Derek Thomas Brown , Andrew George Popplewell , Martyn Kim Robinson , Anthony Shock , Kerry Louise Tyson
IPC分类号： A61K39/395 , C07K16/00 , C12N15/63 , C12N5/10 , C12P21/02
CPC分类号： C07K16/2875 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/52 , C07K2317/55 , C07K2317/71 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
摘要翻译： 本发明提供特异性结合CD154（CD40L）蛋白的结合蛋白，包括抗体，抗体衍生物和抗体片段。 本发明还提供了嵌合，人源化或完全人抗体，抗体衍生物或抗体片段，其特异性结合包含根据SEQ ID NO：1的可变重链序列的人源化Fab片段的表位，并包含可变轻链序列 根据SEQ ID NO：2特异性结合。 本发明的CD154结合蛋白可以引起相对于第二抗-CD154抗体降低的效应子功能。 本发明的CD154结合蛋白可用于诊断和治疗方法，例如治疗和预防包括由CD154-CD40相互作用介导的不期望的免疫应答的疾病。
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