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    Arylvinylazacycloalkane compounds and methods of preparation and use thereof
    1.
    发明授权
    Arylvinylazacycloalkane compounds and methods of preparation and use thereof 有权
    芳基乙烯基氮杂环烷烃化合物及其制备和使用方法

    公开(公告)号：US08063068B2

    公开(公告)日：2011-11-22

    申请号：US12348605

    申请日：2009-01-05

    申请人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Craig Harrison Miller ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    发明人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Craig Harrison Miller ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    IPC分类号： C07D401/02 ,  A61K31/351

    CPC分类号： A61K31/506 ,  C07D405/14

    摘要： Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction of nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of types of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioral disorders and inflammatory disorders within the gastrointestinal system. The compounds can also serve as analgesics in the treatment of acute, chronic or recurrent pain.

    摘要翻译： 公开了式（I）的新型乙烯基氮杂环烷化合物。 这些化合物是各种nAChR的配体。 化合物及其药学上可接受的盐可用于制备旨在预防或治疗与nAChR功能障碍相关的疾病，特别是在中枢神经系统或胃肠系统内的药物组合物和/或药物。 可以治疗的疾病类型的实例包括神经变性疾病，包括中枢神经系统疾病如阿尔茨海默病，认知障碍，运动障碍如帕金森病，药物成瘾，行为障碍和胃肠系统内的炎性疾病。 化合物也可用作治疗急性，慢性或复发性疼痛的镇痛药。

    Arylvinylazacycloalkane compounds and methods of preparation and use thereof
    3.
    发明授权
    Arylvinylazacycloalkane compounds and methods of preparation and use thereof 有权
    芳基乙烯基氮杂环烷烃化合物及其制备和使用方法

    公开(公告)号：US08633222B2

    公开(公告)日：2014-01-21

    申请号：US13033719

    申请日：2011-02-24

    申请人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve ,  Craig Harrison Miller

    发明人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve ,  Craig Harrison Miller

    IPC分类号： A61K31/351 ,  C07D401/02

    CPC分类号： A61K31/506 ,  C07D405/14

    摘要： Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction of nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of types of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioral disorders and inflammatory disorders within the gastrointestinal system. The compounds can also serve as analgesics in the treatment of acute, chronic or recurrent pain.

    摘要翻译： 公开了式（I）的新型乙烯基氮杂环烷化合物。 这些化合物是各种nAChR的配体。 化合物及其药学上可接受的盐可用于制备旨在预防或治疗与nAChR功能障碍相关的疾病，特别是在中枢神经系统或胃肠系统内的药物组合物和/或药物。 可以治疗的疾病类型的实例包括神经变性疾病，包括中枢神经系统疾病如阿尔茨海默病，认知障碍，运动障碍如帕金森病，药物成瘾，行为障碍和胃肠系统内的炎性疾病。 化合物也可用作治疗急性，慢性或复发性疼痛的镇痛药。

    Arylvinylazacycloalkane compounds and methods of preparation and use thereof
    5.
    发明授权
    Arylvinylazacycloalkane compounds and methods of preparation and use thereof 有权
    芳基乙烯基氮杂环烷烃化合物及其制备和使用方法

    公开(公告)号：US07098331B2

    公开(公告)日：2006-08-29

    申请号：US10379868

    申请日：2003-03-05

    申请人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    发明人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    IPC分类号： C07D405/12 ,  C07D239/26

    CPC分类号： A61K31/506 ,  C07D405/14

    摘要： Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction of nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of types of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioral disorders and inflammatory disorders within the gastrointestinal system. The compounds can also serve as analgesics in the treatment of acute, chronic or recurrent pain.

    摘要翻译： 公开了式（I）的新型乙烯基氮杂环烷化合物。 这些化合物是各种nAChR的配体。 化合物及其药学上可接受的盐可用于制备旨在预防或治疗与nAChR功能障碍相关的疾病，特别是在中枢神经系统或胃肠系统内的药物组合物和/或药物。 可以治疗的疾病类型的实例包括神经变性疾病，包括中枢神经系统疾病如阿尔茨海默病，认知障碍，运动障碍如帕金森病，药物成瘾，行为障碍和胃肠系统内的炎性疾病。 化合物也可用作治疗急性，慢性或复发性疼痛的镇痛药。

    Arylvinylazacycloalkane compounds and methods of preparation and use thereof
    6.
    发明授权
    Arylvinylazacycloalkane compounds and methods of preparation and use thereof 有权
    芳基乙烯基氮杂环烷烃化合物及其制备和使用方法

    公开(公告)号：US07714001B2

    公开(公告)日：2010-05-11

    申请号：US12187584

    申请日：2008-08-07

    申请人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    发明人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    IPC分类号： C07D401/02 ,  A61K31/351

    CPC分类号： A61K31/506 ,  C07D405/14

    摘要： Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction of nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of types of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioral disorders and inflammatory disorders within the gastrointestinal system. The compounds can also serve as analgesics in the treatment of acute, chronic or recurrent pain.

    摘要翻译： 公开了式（I）的新型乙烯基氮杂环烷化合物。 这些化合物是各种nAChR的配体。 化合物及其药学上可接受的盐可用于制备旨在预防或治疗与nAChR功能障碍相关的疾病，特别是在中枢神经系统或胃肠系统内的药物组合物和/或药物。 可以治疗的疾病类型的实例包括神经变性疾病，包括中枢神经系统疾病如阿尔茨海默病，认知障碍，运动障碍如帕金森病，药物成瘾，行为障碍和胃肠系统内的炎性疾病。 化合物也可用作治疗急性，慢性或复发性疼痛的镇痛药。

    Arylvinylazacycloalkane Compounds and Methods of Preparation and Use Thereof
    7.
    发明申请
    Arylvinylazacycloalkane Compounds and Methods of Preparation and Use Thereof 有权
    芳基乙烯基氮杂环烷烃化合物及其制备和使用方法

    公开(公告)号：US20080293778A1

    公开(公告)日：2008-11-27

    申请号：US12187584

    申请日：2008-08-07

    申请人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    发明人： Jeffrey Daniel Schmitt ,  Gary Maurice Dull ,  Arielle Genevois-Borella ,  Marc Capet ,  Michel Cheve

    IPC分类号： A61K31/4439 ,  C07D401/14 ,  A61P25/00

    CPC分类号： A61K31/506 ,  C07D405/14

    摘要： Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction of nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of types of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioral disorders and inflammatory disorders within the gastrointestinal system. The compounds can also serve as analgesics in the treatment of acute, chronic or recurrent pain.

    摘要翻译： 公开了式（I）的新型乙烯基氮杂环烷化合物。 这些化合物是各种nAChR的配体。 化合物及其药学上可接受的盐可用于制备旨在预防或治疗与nAChR功能障碍相关的疾病，特别是在中枢神经系统或胃肠系统内的药物组合物和/或药物。 可以治疗的疾病类型的实例包括神经变性疾病，包括中枢神经系统疾病如阿尔茨海默病，认知障碍，运动障碍如帕金森病，药物成瘾，行为障碍和胃肠系统内的炎性疾病。 化合物也可用作治疗急性，慢性或复发性疼痛的镇痛药。