-
1.发明授权1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof 有权1,2,3,4-四氢 - 嘧啶并（1,2-a）嘧啶-6-酮衍生物及其药物用途公开(公告)号：US08846670B2
公开(公告)日：2014-09-30
申请号：US13381790
申请日：2010-07-01
申请人： Eric Bacque , Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
发明人： Eric Bacque , Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
IPC分类号： A61K31/5377 , A61K31/519 , C07D413/14 , C07D487/04 , C07D239/06 , C07D239/42
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , C07D239/06 , C07D239/42 , C07D413/14
摘要： The invention relates to compounds of the formula: or their racemic, enantiomeric or diastereoisomeric isomers, or pharmaceutically acceptable salts of the compounds of formula I or the racemic, enantiomeric or diasteroisomeric isomers.
摘要翻译： 本发明涉及下式的化合物或其外消旋，对映异构体或非对映异构体异构体或式I化合物的药学上可接受的盐或外消旋，对映异构体或非对映体异构体。
-
2.发明授权2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof 有权2,3-二氢-1H-咪唑并（1,2-a）嘧啶-5-酮衍生物及其药物用途公开(公告)号：US08828997B2
公开(公告)日：2014-09-09
申请号：US13381571
申请日：2010-07-01
申请人： Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
发明人： Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
IPC分类号： A61K31/5377 , A61K31/519 , C07D413/14 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , C07D413/14 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415
摘要： The invention relates to a product of formula (I) where R1, R2, R3, and R4 are as defined herein, the therapeutic use of the product, a process to make the product, and a pharmaceutical composition comprising the product.
摘要翻译： 本发明涉及式（I）的产物，其中R 1，R 2，R 3和R 4如本文所定义，产物的治疗用途，制备该产品的方法以及包含该产品的药物组合物。
-
公开(公告)号：USD678213S1
公开(公告)日：2013-03-19
申请号：US29378436
申请日：2010-11-04
申请人： Andreas Karlsson
设计人： Andreas Karlsson
-
4.发明申请NOVEL 1H-PYRIMIDIN-2-ONE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS INHIBITORS OF AKT (PKB) PHOSPHORYLATION 有权新型1H-吡啶二酮衍生物，其制备方法及作为AKT（PKB）磷酸化酶抑制剂的药物用途公开(公告)号：US20120172360A1
公开(公告)日：2012-07-05
申请号：US13331199
申请日：2011-12-20
IPC分类号： A61K31/5377 , A61P35/00 , A61P35/04 , C07D413/14
CPC分类号： C07D403/06 , C07D413/06
摘要： The invention relates to the novel products of formula (I): in which Z represents —O—, —NH or Nalk; n represents 0 to 4; R1 represents Hal, hydroxyl, alkyl or alkoxy; the alkyl and alkoxy radicals being optionally substituted; R2 and R3 represent H, Hal or alkyl optionally substituted with one or more halogen atoms; R4 represents H; these products being in all the isomer forms and the salts, as medicaments, in particular as inhibitors of AKT(PKB) phosphorylation.
摘要翻译： 本发明涉及式（I）的新产物：其中Z表示-O-，-NH或Nalk; n表示0〜4; R1表示Hal，羟基，烷基或烷氧基; 烷基和烷氧基任选被取代; R2和R3表示H，Hal或任选被一个或多个卤素原子取代的烷基; R4表示H; 这些产品是所有异构体形式和盐，作为药物，特别是作为AKT（PKB）磷酸化抑制剂。
-
5.发明授权Derivatives of 1-OXO-1,2-dihydroisoquinoline-5-carboxamides and of 4-OXO-3,4-dihydroquinazoline-8-carboxamides, preparation thereof and application thereof in therapeutics 失效1-OXO-1,2-二氢异喹啉-5-甲酰胺和4-OXO-3,4-二氢喹唑啉-8-甲酰胺的衍生物，其制备及其在治疗中的应用公开(公告)号：US08030320B2
公开(公告)日：2011-10-04
申请号：US12693598
申请日：2010-01-26
IPC分类号： A61K31/517
CPC分类号： C07D217/24 , C07D239/88
摘要： The present invention relates to compounds of formula I, to the preparation thereof and to the therapeutic use thereof.
摘要翻译： 本发明涉及式I化合物及其制备及其治疗用途。
-
公开(公告)号：USD632656S1
公开(公告)日：2011-02-15
申请号：US29294625
申请日：2008-01-18
申请人： Andreas Karlsson
设计人： Andreas Karlsson
-
公开(公告)号：US20060153435A1
公开(公告)日：2006-07-13
申请号：US10516800
申请日：2003-06-19
IPC分类号： G06E3/00
CPC分类号： G06T7/0012 , G06K9/0014 , G06K9/34 , G06T7/11 , G06T7/187 , G06T7/64 , G06T2207/10056 , G06T2207/30024
摘要： The present invention relates to the segmentation of two-dimensional gel electrophoresis images (2D images). The method according to the invention associates an initial protein seed candidate with an interface circumscribing said seed and thereafter brings said interface to evolve in accordance with a defined speed function F(x, y). The evolution of the interface is halted by a stopping criterion, C. According to the invention, the speed function can depend on a wide variety of parameters such as the pixel intensity, the curvature of the pixel intensity, the distance to the initial seed, the curvature and/or shape and/or normal direction and/or position of the evolving interface. The stopping criterion depends e.g. on the speed function F and/or the time of arrival T(x, y) and/or the departure time Td for said interface. The invention provides criteria for a specific treatment of saturated spots and to mike sure that interfaces never overlap.
摘要翻译： 本发明涉及二维凝胶电泳图像（2D图像）的分割。 根据本发明的方法将初始蛋白质种子候选物与限定所述种子的界面相关联，然后使所述界面根据定义的速度函数F（x，y）进行演化。 接口的演变由停止标准C停止。根据本发明，速度函数可以取决于各种各样的参数，例如像素强度，像素强度的曲率，到初始种子的距离， 演变界面的曲率和/或形状和/或法线方向和/或位置。 停止标准取决于 对于所述接口，速度函数F和/或到达时间T（x，y）和/或出发时间T 。 本发明提供了对饱和斑点的具体处理的标准，并确保界面不重叠。
-
公开(公告)号：US20220289054A1
公开(公告)日：2022-09-15
申请号：US17694272
申请日：2022-03-14
摘要： An electric vehicle charger charging apparatus is configured to suspend from a canopy and connect to an electric vehicle from above the vehicle. The canopy has a purlin frame and supports a photovoltaic module for generating electricity. The electric vehicle charging apparatus suspends from the purlin frame of the canopy by a mounting structure. The mounting structure includes a first vertical brace and a second vertical brace having bottom connection points connectable to mounting points on a vehicle charger and top connection points connectable to a block brace coupled to the purlin frame. The mounting points on the vehicle charger are level to horizontal ground surface and the canopy is sloped with respect to the horizontal ground surface such that the second vertical brace has a greater length between the top and bottom connection points than the first vertical brace.
-
公开(公告)号：US20170102036A1
公开(公告)日：2017-04-13
申请号：US15278082
申请日：2016-09-28
申请人： Yoann Hebrard , Defeng Lang , Andreas Karlsson , Victor Martinez , Frank de Wit
发明人： Yoann Hebrard , Defeng Lang , Andreas Karlsson , Victor Martinez , Frank de Wit
CPC分类号： F16C41/008 , F16C19/386 , F16C19/52 , F16C33/3831 , F16C33/44 , F16C33/4611 , F16C33/4635 , F16C33/56 , F16C41/002 , F16C2202/40 , F16C2233/00 , F16C2300/02 , G01M13/04 , H01Q1/27 , H01Q7/00
摘要： The invention relates to a bearing cage including a bearing cage main body made of a polymer material and having pockets for receiving at least one row of rolling elements of a bearing. The cage is provided with a passive resonant circuit including an antenna coil attached to the cage main body. It is proposed that the antenna coil is formed as a conductive layer directly attached to the cage material of the bearing cage main body and is designed so as to have a breaking point less than or equal to a breaking point of the cage material. Thus, a rupture in the cage main body ruptures the antenna coil, changing the resonance behaviour of the passive resonant circuit.
-
10.发明授权(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives, preparation thereof and pharmaceutical use thereof as AKT(PKB) phosphorylation inhibitors 有权（6-氧代-1,6-二氢嘧啶-2-基）酰胺衍生物，其制备方法及其作为AKT（PKB）磷酸化抑制剂的药物用途公开(公告)号：US08791255B2
公开(公告)日：2014-07-29
申请号：US13338011
申请日：2011-12-27
申请人： Jean-Christophe Carry , Victor Certal , Frank Halley , Karl Andreas Karlsson , Laurent Schio , Fabienne Thompson
发明人： Jean-Christophe Carry , Victor Certal , Frank Halley , Karl Andreas Karlsson , Laurent Schio , Fabienne Thompson
IPC分类号： C07D413/04
CPC分类号： C07D239/22 , C07D239/47 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D471/04
摘要： The invention relates to the novel materials of formula (I), wherein each of the substituents R, R1, R2, R3, R4 and R5 is as defined herein. The materials are useful as inhibitors of AKT(PKB) phosphorylation.
摘要翻译： 本发明涉及式（I）的新型材料，其中取代基R 1，R 2，R 3，R 4和R 5中的每一个如本文所定义。 该物质可用作AKT（PKB）磷酸化抑制剂。
-
-
-
-
-
-
-
-
-
搜索结果
41 条记录 (耗时 0.019 秒)
