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1.发明授权2-(4-oxo-4H-quinazolin-3-yl)acetamides and their use as vasopressin V3 antagonists 有权2-（4-氧代-4H-喹唑啉-3-基）乙酰胺及其作为血管加压素V3拮抗剂的用途公开(公告)号：US07807686B2
公开(公告)日：2010-10-05
申请号：US11908221
申请日：2006-03-10
申请人： Jeffrey Letourneau , Christopher Riviello , Koc-Kan Hoc , Jui-Hsiang Chan , Michael Ohlmeyer , Patrick Jokiel , Irina Neagu , John Richard Morphy , Susan Elizabeth Napier
发明人： Jeffrey Letourneau , Christopher Riviello , Koc-Kan Hoc , Jui-Hsiang Chan , Michael Ohlmeyer , Patrick Jokiel , Irina Neagu , John Richard Morphy , Susan Elizabeth Napier
IPC分类号： A61K31/517
CPC分类号： C07D409/04 , C07D239/91 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/04
摘要： The present invention relates to 2-(4-oxo4H-quinazolin-3-yl) acetamicle derivatives of formula (I), and to their use as vasopressin V3 antagonists, particularly for the treatment of depression.
摘要翻译： 本发明涉及式（I）的2-（4-氧代-4-喹唑啉-3-基）乙酰胺衍生物及其作为加压素V3拮抗剂的用途，特别是用于治疗抑郁症。
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公开(公告)号：US07906504B2
公开(公告)日：2011-03-15
申请号：US11852737
申请日：2007-09-10
申请人： Jeffrey Letourneau , Jui-Hsiang Chan , Patrick Jokiel , Michael Ohlmeyer , Irina Neagu , Christopher Riviello , John Richard Morphy , Susan Elizabeth Napier , Koc-Kan Ho
发明人： Jeffrey Letourneau , Jui-Hsiang Chan , Patrick Jokiel , Michael Ohlmeyer , Irina Neagu , Christopher Riviello , John Richard Morphy , Susan Elizabeth Napier , Koc-Kan Ho
IPC分类号： C07D217/24 , A61K31/472
CPC分类号： C07D217/24 , C07D401/12
摘要： Disclosed herein are 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivative of formula I, or pharmaceutically acceptable salts or solvates thereof wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivatives according to the present invention and their use in therapy.
摘要翻译： 本文公开了式I的2-（1-氧代-1H-异喹啉-2-基）乙酰胺衍生物或其药学上可接受的盐或溶剂合物，其中每个取代基被给出如说明书和权利要求书中所阐述的定义。 还公开了包含根据本发明的2-（1-氧代-1H-异喹啉-2-基）乙酰胺衍生物及其在治疗中的用途的药物组合物。
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3.发明申请2-(4-Oxo-4H-Quinazolin-3-Yl) Acetamides and Their Use as Vasopressin V3 Antagonists 有权2-（4-氧代-4H-喹唑啉-3-基）乙酰胺及其作为加压素V3拮抗剂的用途公开(公告)号：US20080214553A1
公开(公告)日：2008-09-04
申请号：US11908221
申请日：2006-03-10
申请人： Jeffrey Letourneau , Christopher Riviello , Koc-Kan Ho , Jui-Hsiang Chan , Michael Ohlmeyer , Patrick Jokiel , Irina Neagu , John Richard Morphy , Susan Elizabeth Napier
发明人： Jeffrey Letourneau , Christopher Riviello , Koc-Kan Ho , Jui-Hsiang Chan , Michael Ohlmeyer , Patrick Jokiel , Irina Neagu , John Richard Morphy , Susan Elizabeth Napier
IPC分类号： A61K31/517 , C07D403/02
CPC分类号： C07D409/04 , C07D239/91 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/04
摘要： The present invention relates to 2-(4-oxo4H-quinazolin-3-yl)acetamicle derivatives of formula (I), and to their use as vasopressin V3 antagonists, particularly for the treatment of depression.
摘要翻译： 本发明涉及式（I）的2-（4-氧代-4-喹唑啉-3-基）乙酰胺衍生物及其作为加压素V3拮抗剂的用途，特别是用于治疗抑郁症。
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公开(公告)号：US20080064678A1
公开(公告)日：2008-03-13
申请号：US11852737
申请日：2007-09-10
申请人： Jeffrey Letourneau , Jui-Hsiang Chan , Patrick Jokiel , Michael Ohlmeyer , Irina Neagu , Christopher Riviello , John Morphy , Susan Napier , Koc-Kan Ho
发明人： Jeffrey Letourneau , Jui-Hsiang Chan , Patrick Jokiel , Michael Ohlmeyer , Irina Neagu , Christopher Riviello , John Morphy , Susan Napier , Koc-Kan Ho
IPC分类号： C07D217/24 , A61K31/397 , A61K31/472 , A61P25/00
CPC分类号： C07D217/24 , C07D401/12
摘要： Disclosed herein are 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivative of formula I, or pharmaceutically acceptable salts or solvates thereof wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising 2-(1-oxo-1H-isoquinolin-2-yl)acetamide derivatives according to the present invention and their use in therapy.
摘要翻译： 本文公开了式I的2-（1-氧代-1H-异喹啉-2-基）乙酰胺衍生物或其药学上可接受的盐或溶剂合物，其中每个取代基被给出如说明书和权利要求中所阐述的定义。 还公开了包含根据本发明的2-（1-氧代-1H-异喹啉-2-基）乙酰胺衍生物及其在治疗中的用途的药物组合物。
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公开(公告)号：US07820649B2
公开(公告)日：2010-10-26
申请号：US11852762
申请日：2007-09-10
申请人： Jeffrey Letourneau , Patrick Jokiel , Susan Elizabeth Napier , Koc-Kan Ho , Michael Ohlmeyer , Duncan Robert McArthur , Fiona Jeremiah , Paul David Ratcliffe , Jurgen Schulz
发明人： Jeffrey Letourneau , Patrick Jokiel , Susan Elizabeth Napier , Koc-Kan Ho , Michael Ohlmeyer , Duncan Robert McArthur , Fiona Jeremiah , Paul David Ratcliffe , Jurgen Schulz
IPC分类号： C07D239/88
CPC分类号： C07D403/04 , C07D217/24 , C07D239/91 , C07D401/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/08 , C07D487/04
摘要： Disclosed herein are quinazolinone or isoquinolinone derivatives of formula I, or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising quinazolinone or isoquinolinone according to the present invention and its use in therapy.
摘要翻译： 本文公开的式I的喹唑啉酮或异喹啉酮衍生物或其药学上可接受的盐或溶剂化物，其中每个取代基都给出如说明书和权利要求书中所阐述的定义。 还公开了包含根据本发明的喹唑啉酮或异喹啉酮及其在治疗中的用途的药物组合物。
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6.发明申请公开(公告)号：US20070037822A1
公开(公告)日：2007-02-15
申请号：US11422710
申请日：2006-06-07
IPC分类号： A61K31/513 , A61K31/4965 , A61K31/4412 , C07D213/63 , C07D239/02
CPC分类号： C07D213/82 , C07D239/26 , C07D239/36 , C07D241/24 , C07D295/088 , C07D403/04 , C07D403/12 , C07D413/04
摘要： Substituted pyridines, pyrimidines, pyrazines, pyridinones, pyrimidinones, pyrazinones and phenylacetamides useful in treating depression, stress and other disorders are disclosed. The compounds are of the formualae: Other embodiments are also disclosed.
摘要翻译： 公开了用于治疗抑郁症，压力和其它疾病的取代的吡啶，嘧啶，吡嗪，吡啶酮，嘧啶酮，吡嗪酮和苯乙酰胺。 化合物是形式：其他实施方案也被公开。
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公开(公告)号：US20080090802A1
公开(公告)日：2008-04-17
申请号：US11852762
申请日：2007-09-10
申请人： Jeffrey Letourneau , Patrick Jokiel , Susan Napier , Koc-Kan Ho , Michael Ohlmeyer , Duncan McArthur , Fiona Jeremiah , Paul Ratcliffe , Jurgen Schulz
发明人： Jeffrey Letourneau , Patrick Jokiel , Susan Napier , Koc-Kan Ho , Michael Ohlmeyer , Duncan McArthur , Fiona Jeremiah , Paul Ratcliffe , Jurgen Schulz
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/551 , A61P25/00 , C07D401/02 , C07D403/02 , C07D413/14
CPC分类号： C07D403/04 , C07D217/24 , C07D239/91 , C07D401/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/08 , C07D487/04
摘要： Disclosed herein are quinazolinone derivatives of formula I, or pharmaceutically acceptable salts or solvates thereof, wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions comprising quinazolinone or isoquinolinone according to the present invention and its use in therapy.
摘要翻译： 本文公开的式I的喹唑啉酮衍生物或其药学上可接受的盐或溶剂化物，其中每个取代基都给出如说明书和权利要求书中所阐述的定义。 还公开了包含根据本发明的喹唑啉酮或异喹啉酮及其在治疗中的用途的药物组合物。
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8.发明授权公开(公告)号：US08350043B2
公开(公告)日：2013-01-08
申请号：US11422710
申请日：2006-06-07
申请人： Jeffrey John Letourneau , Koc-Kan Ho , Michael J. Ohlmeyer , Patrick Jokiel , Christopher Mark Riviello
发明人： Jeffrey John Letourneau , Koc-Kan Ho , Michael J. Ohlmeyer , Patrick Jokiel , Christopher Mark Riviello
IPC分类号： C07D213/02 , C07D213/24 , C07D213/63 , A61K31/44 , A61K31/4412 , A61P25/22 , A61P25/24
CPC分类号： C07D213/82 , C07D239/26 , C07D239/36 , C07D241/24 , C07D295/088 , C07D403/04 , C07D403/12 , C07D413/04
摘要： Substituted pyridines, pyrimidines, pyrazines, pyridinones, pyrimidinones, pyrazinones and phenylacetamides useful in treating depression, stress and other disorders are disclosed. The compounds are of the formualae: Other embodiments are also disclosed.
摘要翻译： 公开了用于治疗抑郁症，压力和其它疾病的取代的吡啶，嘧啶，吡嗪，吡啶酮，嘧啶酮，吡嗪酮和苯乙酰胺。 化合物是形式：其他实施方案也被公开。
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