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1.发明申请ASSAYS AND PEPTIDE SUBSTRATE FOR DETERMINING AGGRECAN DEGRADING METALLO PROTEASE ACTIVITY 审中-公开用于测定AGGRECAN降解金属蛋白酶活性的测定和基质底物公开(公告)号：US20070238136A1
公开(公告)日：2007-10-11
申请号：US11733232
申请日：2007-04-10
申请人： Jeffrey Miller , Elizabeth Arner , Robert Copeland , Gary Davis , Ruiqin Liu , Michael Pratta , Micky Tortorella
发明人： Jeffrey Miller , Elizabeth Arner , Robert Copeland , Gary Davis , Ruiqin Liu , Michael Pratta , Micky Tortorella
CPC分类号： C12N9/6489 , A61K38/00 , C07K16/40 , C12Q1/37 , G01N33/6887 , G01N2333/96486 , G01N2500/00 , G01N2800/102
摘要： This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use as inhibitors of ADMP activity.
摘要翻译： 本发明涉及确定存在或不存在表现出聚集蛋白聚糖蛋白聚糖酶或ADMP活性的蛋白质的测定法。 本发明还涉及作为ADMP底物的肽，其用于各种测定以确定ADMP活性的存在或不存在，以及它们作为ADMP活性抑制剂的用途。
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公开(公告)号：US09371305B2
公开(公告)日：2016-06-21
申请号：US14401600
申请日：2012-08-10
申请人： Yanmei Zhang , John Jeffrey Talley , Mark G. Obukowicz , Zhengchao Tu , Micky Tortorella , Yican Wang , Jianqi Liu , Yan Chen , Xiaorong Liu , Xin Lu
发明人： Yanmei Zhang , John Jeffrey Talley , Mark G. Obukowicz , Zhengchao Tu , Micky Tortorella , Yican Wang , Jianqi Liu , Yan Chen , Xiaorong Liu , Xin Lu
IPC分类号： C07D311/58
CPC分类号： A61K31/353 , A61K31/382 , A61K31/47 , C07D311/58
摘要： The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
摘要翻译： 本发明公开了具有式（I）所示结构特征的氘代苯并吡喃化合物或其药学上可接受的盐或立体异构体或其前药分子。 具有优异的抗炎和镇痛作用和抑制肿瘤细胞生长的能力，这些化合物是新型的COX-2选择性抑制剂。 本申请公开的化合物及其药学上可接受的盐可用于制备用于治疗或预防肿瘤的抗炎和镇痛药物和药物。
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公开(公告)号：US20150133538A1
公开(公告)日：2015-05-14
申请号：US14401600
申请日：2012-08-10
申请人： Yanmei Zhang , John Jeffrey Talley , Mark G. Obukowicz , Zhengchao Tu , Micky Tortorella , Yican Wang , Jianqi Liu , Yan Chen , Xiaorong Liu , Xin Lu
发明人： Yanmei Zhang , John Jeffrey Talley , Mark G. Obukowicz , Zhengchao Tu , Micky Tortorella , Yican Wang , Jianqi Liu , Yan Chen , Xiaorong Liu , Xin Lu
IPC分类号： C07D311/58
CPC分类号： A61K31/353 , A61K31/382 , A61K31/47 , C07D311/58
摘要： The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.
摘要翻译： 本发明公开了具有式（I）所示结构特征的氘代苯并吡喃化合物或其药学上可接受的盐或立体异构体或其前药分子。 具有优异的抗炎和镇痛作用和抑制肿瘤细胞生长的能力，这些化合物是新型的COX-2选择性抑制剂。 本申请公开的化合物及其药学上可接受的盐可用于制备用于治疗或预防肿瘤的抗炎和镇痛药物和药物。
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公开(公告)号：US20050090466A1
公开(公告)日：2005-04-28
申请号：US10942581
申请日：2004-09-16
CPC分类号： A61K38/02 , A61K38/07 , A61K38/1709 , A61K38/55
摘要： Disclosed are methods and compositions for the treatment of arthritis using inhibitors of PACE4.
摘要翻译： 公开了使用PACE4抑制剂治疗关节炎的方法和组合物。
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