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1.发明授权公开(公告)号：US09095581B2
公开(公告)日：2015-08-04
申请号：US12956177
申请日：2010-11-30
申请人： Jeffrey N. Miner , Mark S. Chapman , Barry Quart , Alex Adjei , Chunrong Yu
发明人： Jeffrey N. Miner , Mark S. Chapman , Barry Quart , Alex Adjei , Chunrong Yu
IPC分类号： A61K31/4439 , A61K31/18 , A61K31/4412 , A61K45/06
CPC分类号： A61K31/4412 , A61K31/18 , A61K31/44 , A61K31/4439 , A61K31/702 , A61K45/06 , A61N5/10 , A61K2300/00
摘要： This invention concerns combinations of inhibitors of MEK, Raf protein kinases, and other kinases including VEGFR1-3 and PDGFR-β. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer and other hyperproliferative disorders.
摘要翻译： 本发明涉及MEK，Raf蛋白激酶和其它激酶（包括VEGFR1-3和PDGFR-＆bgr）的抑制剂的组合。 本发明还涉及包含本文所述化合物和本文所述化合物和组合物的使用方法的药物组合物，包括用于治疗和/或预防癌症和其它过度增殖性疾病。
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2.发明授权Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same 有权包括作为MEK抑制剂的多晶型物的N-（芳基氨基）磺酰胺的衍生物以及组合物，使用方法及其制备方法公开(公告)号：US08648116B2
公开(公告)日：2014-02-11
申请号：US12671287
申请日：2008-07-28
申请人： Jean-Michel Vernier , Colin Edward Rowlings , Jean-Luc Girardet , Stuart Dimock , Barry Quart , Jeffrey N. Miner
发明人： Jean-Michel Vernier , Colin Edward Rowlings , Jean-Luc Girardet , Stuart Dimock , Barry Quart , Jeffrey N. Miner
IPC分类号： A61K31/185 , C07C311/00
CPC分类号： A61K45/06 , A61K31/352 , A61K2300/00
摘要： This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer, hyperproliferative diseases and inflammatory conditions. The invention also concerns methods of making the compounds and compositions described herein.
摘要翻译： 本发明涉及作为MEK的抑制剂的N-（2-芳基氨基）芳基磺酰胺化合物，其包括具有特定的粉末X射线衍射图和/或特异性差示扫描量热分析图的结晶多晶型。 本发明还涉及包含本文所述化合物和本文所述化合物和组合物的使用方法的药物组合物，包括用于治疗和/或预防癌症，过度增殖性疾病和炎性病症。 本发明还涉及制备本文所述的化合物和组合物的方法。
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3.发明申请DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES INCLUDING POLYMORPHS AS INHIBITORS OF MEK AS WELL AS COMPOSITIONS, METHODS OF USE AND METHODS FOR PREPARING THE SAME 有权包括作为组合物的MEK的抑制剂的聚（对甲苯胺）磺酰胺的衍生物，使用方法和制备它们的方法公开(公告)号：US20110060049A1
公开(公告)日：2011-03-10
申请号：US12671287
申请日：2008-07-28
申请人： Jean-Michel Vernier , Colin Edward Rowlings , Jean-Luc Girardet , Stuart Dimock , Barry Quart , Jeffrey N. Miner
发明人： Jean-Michel Vernier , Colin Edward Rowlings , Jean-Luc Girardet , Stuart Dimock , Barry Quart , Jeffrey N. Miner
CPC分类号： A61K45/06 , A61K31/352 , A61K2300/00
摘要： This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer, hyperproliferative diseases and inflammatory conditions. The invention also concerns methods of making the compounds and compositions described herein.
摘要翻译： 本发明涉及作为MEK的抑制剂的N-（2-芳基氨基）芳基磺酰胺化合物，其包括具有特定的粉末X射线衍射图和/或特异性差示扫描量热分析图的结晶多晶型。 本发明还涉及包含本文所述化合物和本文所述化合物和组合物的使用方法的药物组合物，包括用于治疗和/或预防癌症，过度增殖性疾病和炎性病症。 本发明还涉及制备本文所述的化合物和组合物的方法。
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