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公开(公告)号:US20140235469A1
公开(公告)日:2014-08-21
申请号:US14064709
申请日:2013-10-28
申请人: Jeffrey SHELTON , Kevin KELNAR , Stephanie VOLZ , Alex ADAI , David BROWN
发明人: Jeffrey SHELTON , Kevin KELNAR , Stephanie VOLZ , Alex ADAI , David BROWN
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6886 , C12Q2600/112 , C12Q2600/16 , C12Q2600/178
摘要: This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing prostate disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as prostate cancer.
摘要翻译: 该应用描述了可用作血清或血浆生物标志物的miRNA,用于表征患者中的前列腺疾病。 这些miRNA生物标志物可以单独使用或与其它标志物组合使用,用于诊断,预后或监测前列腺癌等疾病。
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公开(公告)号:US20120276627A1
公开(公告)日:2012-11-01
申请号:US13365646
申请日:2012-02-03
申请人: Kevin KELNAR , David Brown
发明人: Kevin KELNAR , David Brown
CPC分类号: C12N15/113 , A61K31/713 , A61K45/06 , C12N2310/141 , C12N2310/317 , C12N2310/321 , C12N2310/3521
摘要: Embodiments concern methods and compositions involving miR-124 mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-124 sequence and a complementary passenger strand.
摘要翻译: 实施方案涉及涉及miR-124模拟物的方法和组合物。 在一些实施方案中,存在具有经修饰的核苷酸的双链RNA分子,其具有miR-124序列和补体乘客链的活性链。
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