公开(公告)号：US20090294649A1

公开(公告)日：2009-12-03

申请号：US12473570

申请日：2009-05-28

申请人： Jeffrey Shabanowitz ,  Philip D. Compton ,  Lee Earley ,  George C. Stafford, JR. ,  Donald F. Hunt ,  Christopher Mullen

发明人： Jeffrey Shabanowitz ,  Philip D. Compton ,  Lee Earley ,  George C. Stafford, JR. ,  Donald F. Hunt ,  Christopher Mullen

IPC分类号： B01D59/44 ,  H01J49/00 ,  H01J27/00

CPC分类号： H01J49/12 ,  H01J49/0072

摘要： A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).

摘要翻译： 公开了用于质谱仪的前端试剂离子源。 将试剂蒸气供给到位于质谱仪室内的试剂电离体并保持在低真空压力下。 试剂离子通过试剂蒸气分子与离子化体积内的放电（例如，辉光放电）的相互作用而形成，并进入质谱仪的室。 沿着分析物离子路径定位的至少一个离子光学元件将试剂离子输送到质谱仪的连续室。 试剂离子可与分析物离子组合以进行离子离子研究，例如电子转移离解（ETD）。