公开(公告)号：US08119984B2

公开(公告)日：2012-02-21

申请号：US12473570

申请日：2009-05-28

申请人： Jeffrey Shabanowitz ,  Philip D. Compton ,  Lee Earley ,  George C. Stafford, Jr. ,  Donald F. Hunt ,  Christopher Mullen

发明人： Jeffrey Shabanowitz ,  Philip D. Compton ,  Lee Earley ,  George C. Stafford, Jr. ,  Donald F. Hunt ,  Christopher Mullen

IPC分类号： H01J49/10

CPC分类号： H01J49/12 ,  H01J49/0072

摘要： A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).

摘要翻译： 公开了用于质谱仪的前端试剂离子源。 将试剂蒸气供给到位于质谱仪室内的试剂电离体并保持在低真空压力下。 试剂离子通过试剂蒸气分子与离子化体积内的放电（例如，辉光放电）的相互作用而形成，并进入质谱仪的室。 沿着分析物离子路径定位的至少一个离子光学元件将试剂离子输送到质谱仪的连续室。 试剂离子可与分析物离子组合以进行离子离子研究，例如电子转移离解（ETD）。

公开(公告)号：US20090294649A1

公开(公告)日：2009-12-03

申请号：US12473570

申请日：2009-05-28

申请人： Jeffrey Shabanowitz ,  Philip D. Compton ,  Lee Earley ,  George C. Stafford, JR. ,  Donald F. Hunt ,  Christopher Mullen

发明人： Jeffrey Shabanowitz ,  Philip D. Compton ,  Lee Earley ,  George C. Stafford, JR. ,  Donald F. Hunt ,  Christopher Mullen

IPC分类号： B01D59/44 ,  H01J49/00 ,  H01J27/00

CPC分类号： H01J49/12 ,  H01J49/0072

摘要： A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).

摘要翻译： 公开了用于质谱仪的前端试剂离子源。 将试剂蒸气供给到位于质谱仪室内的试剂电离体并保持在低真空压力下。 试剂离子通过试剂蒸气分子与离子化体积内的放电（例如，辉光放电）的相互作用而形成，并进入质谱仪的室。 沿着分析物离子路径定位的至少一个离子光学元件将试剂离子输送到质谱仪的连续室。 试剂离子可与分析物离子组合以进行离子离子研究，例如电子转移离解（ETD）。

公开(公告)号：US07675031B2

公开(公告)日：2010-03-09

申请号：US12129608

申请日：2008-05-29

申请人： Michael Konicek ,  Adrian Land ,  Gershon Perelman ,  Lee Earley ,  Mark Hardman

发明人： Michael Konicek ,  Adrian Land ,  Gershon Perelman ,  Lee Earley ,  Mark Hardman

IPC分类号： H01J49/42 ,  H05H9/02

CPC分类号： H01J49/063 ,  H01J49/4225

摘要： Auxiliary electrodes for creating drag fields may be provided as arrays of finger electrodes on thin substrates such as printed circuit board material for insertion between main RF electrodes of a multipole. A progressive range of voltages can be applied along lengths of the auxiliary electrodes by implementing a voltage divider that utilizes static resisters interconnecting individual finger electrodes of the arrays. Dynamic voltage variations may be applied to individual finger electrodes or to groups of the finger electrodes.

摘要翻译： 用于产生拖曳场的辅助电极可以被提供为诸如印刷电路板材料的薄基板上的指状电极阵列，用于插入多极的主RF电极之间。 可以通过实施使用互连阵列的各个指状电极的静电阻的分压器来沿辅助电极的长度施加逐渐的电压范围。 动态电压变化可以施加到各个指状电极或指状电极的组。

公开(公告)号：US20080245963A1

公开(公告)日：2008-10-09

申请号：US11962009

申请日：2007-12-20

申请人： Adrian Land ,  Lee Earley ,  George C. Stafford

发明人： Adrian Land ,  Lee Earley ,  George C. Stafford

IPC分类号： H01J49/14

CPC分类号： H01J49/0072

摘要： A front-end ion source for a mass spectrometer generates both analyte and reagent ions. The reagent source may include a heater for vaporizing a condensed-phase reagent substance and an electron source for ionizing reagent molecules. The interior of the reagent ionization chamber is purged with a purge gas to avoid or minimize reaction of the reagent ions with oxygen or other reactive species, thereby enabling operation of the reagent ionization chamber at or near atmospheric pressure. The reagent and analyte ions are directed into a reduced-pressure chamber through separate passageways. An ion transport optic selectively transmits one of the analyte ions or the reagent ions from the reduced-pressure chamber to downstream regions of the mass spectrometer.

摘要翻译： 用于质谱仪的前端离子源产生分析物和试剂离子。 试剂源可以包括用于蒸发冷凝相试剂物质的加热器和用于电离试剂分子的电子源。 试剂电离室的内部用净化气体吹扫，以避免或最小化试剂离子与氧或其它反应物质的反应，从而使试剂电离室在大气压力或接近大气压力下操作。 试剂和分析物离子通过单独的通道导入减压室。 离子传输光学选择性地将分析物离子或试剂离子中的一种从减压室传输到质谱仪的下游区域。

公开(公告)号：US20060016976A1

公开(公告)日：2006-01-26

申请号：US11077105

申请日：2005-03-09

申请人： Adrian Land ,  Lee Earley ,  Mark Hardman ,  Rexford Heller ,  Michael Senko

发明人： Adrian Land ,  Lee Earley ,  Mark Hardman ,  Rexford Heller ,  Michael Senko

IPC分类号： B01D59/44

CPC分类号： H01J49/4265 ,  H01J49/40

摘要： A method of controlling the population of ions in a mass spectrometer in which a first sample of ions is provided in the mass spectrometer, a measure of abundance of a species of interest in the first sample of ions is determined, the measure of abundance comprising an intensity value, and a second sample of ions is introduced into the mass spectrometer. The second sample of ions is introduced in an amount determined at least in part on the measure of abundance of the species of interest in the first sample of ions.

摘要翻译： 一种控制质谱仪中离子质量的方法，其中在质谱仪中提供第一离子样品，确定第一离子样品中感兴趣的物种的丰度的量度，其含量为 强度值和第二离子样品引入质谱仪。 第二离子样品的引入量至少部分取决于第一离子样品中感兴趣物种丰度的量度。

公开(公告)号：US07109475B1

公开(公告)日：2006-09-19

申请号：US11116707

申请日：2005-04-28

申请人： Mark E. Hardman ,  Lee Earley ,  Adrian Land

发明人： Mark E. Hardman ,  Lee Earley ,  Adrian Land

IPC分类号： H01J49/40 ,  B01D59/44

CPC分类号： H01J49/0036 ,  H01J49/025 ,  H01J49/40

摘要： Disclosed are a time-of-flight mass spectrometer and signal processing electronics. The signal processing electronics include a plurality of time-to-digital converters configured to receive signal pulses from the same detector anode within the time-of-flight mass spectrometer. The signal processing electronics are further configured to differentiate, and compensate for, those signal pulses caused by the detection of more than one ion. Differentiation and compensation are achieved by using the time-to-digital converters to detect the leading and trailing edges of a signal pulse. The time difference between the detection of the leading edge and detection of the trailing edge is indicative of whether or not the signal pulse was generated by the detection of more than one ion.

摘要翻译： 披露了飞行时间质谱仪和信号处理电子学。 信号处理电子器件包括多个时间 - 数字转换器，其被配置为在飞行时间质谱仪内接收来自相同检测器阳极的信号脉冲。 信号处理电子器件还被配置为区分并补偿由多于一个离子的检测引起的那些信号脉冲。 通过使用时间 - 数字转换器来检测信号脉冲的前沿和后沿来实现差分和补偿。 前沿检测与后沿检测之间的时间差表示通过检测多于一个离子是否产生了信号脉冲。

公开(公告)号：US20060043283A1

公开(公告)日：2006-03-02

申请号：US10931809

申请日：2004-08-31

申请人： Stephen Davis ,  Lee Earley ,  Mark Hardman ,  Adrian Land ,  Gershon Perelman

发明人： Stephen Davis ,  Lee Earley ,  Mark Hardman ,  Adrian Land ,  Gershon Perelman

IPC分类号： H01J49/00

CPC分类号： H01J49/40

摘要： An apparatus that comprises material which have different thermal expansion coefficients, combined in such a way that the length of the drift region is variant, and self adjusting with temperature. The adjustment is such as to compensate for the length changes resulting from thermal expansion or contraction in other ion optical elements, such that ions of substantially equivalent mass to charge ratios maintain a constant flight time though the system. This allows for use of standard construction methods for the ion optical elements.

摘要翻译： 一种包括具有不同热膨胀系数的材料的装置，其组合使得漂移区域的长度是不同的，并且随着温度自调节。 该调整是为了补偿由其它离子光学元件的热膨胀或收缩导致的长度变化，使得基本相当的质荷比的离子通过系统保持恒定的飞行时间。 这允许使用用于离子光学元件的标准施工方法。

公开(公告)号：US20090294641A1

公开(公告)日：2009-12-03

申请号：US12129608

申请日：2008-05-29

申请人： Michael Konicek ,  Adrian Land ,  Gershon Perleman ,  Lee Earley ,  Mark Hardman

发明人： Michael Konicek ,  Adrian Land ,  Gershon Perleman ,  Lee Earley ,  Mark Hardman

IPC分类号： B01D59/44

CPC分类号： H01J49/063 ,  H01J49/4225

摘要： Auxiliary electrodes for creating drag fields may be provided as arrays of finger electrodes on thin substrates such as printed circuit board material for insertion between main RF electrodes of a multipole. A progressive range of voltages can be applied along lengths of the auxiliary electrodes by implementing a voltage divider that utilizes static resisters interconnecting individual finger electrodes of the arrays. Dynamic voltage variations may be applied to individual finger electrodes or to groups of the finger electrodes.

摘要翻译： 用于产生拖曳场的辅助电极可以被提供为诸如印刷电路板材料的薄基板上的指状电极阵列，用于插入多极的主RF电极之间。 可以通过实施使用互连阵列的各个指状电极的静电阻的分压器来沿辅助电极的长度施加逐渐的电压范围。 动态电压变化可以施加到各个指状电极或指状电极的组。

公开(公告)号：US07312441B2

公开(公告)日：2007-12-25

申请号：US11077105

申请日：2005-03-09

申请人： Adrian Land ,  Lee Earley ,  Mark Hardman ,  Rexford T. Heller ,  Michael W. Senko

发明人： Adrian Land ,  Lee Earley ,  Mark Hardman ,  Rexford T. Heller ,  Michael W. Senko

IPC分类号： B01D59/44

CPC分类号： H01J49/4265 ,  H01J49/40

摘要： A method of controlling the population of ions in a mass spectrometer in which a first sample of ions is provided in the mass spectrometer, a measure of abundance of a species of interest in the first sample of ions is determined, the measure of abundance comprising an intensity value, and a second sample of ions is introduced into the mass spectrometer. The second sample of ions is introduced in an amount determined at least in part on the measure of abundance of the species of interest in the first sample of ions.

摘要翻译： 一种控制质谱仪中离子质量的方法，其中在质谱仪中提供第一离子样品，确定第一离子样品中感兴趣的物种的丰度的量度，其含量为 强度值和第二离子样品引入质谱仪。 第二离子样品的引入量至少部分取决于第一离子样品中感兴趣物种丰度的量度。

公开(公告)号：US06998607B1

公开(公告)日：2006-02-14

申请号：US10931809

申请日：2004-08-31

申请人： Stephen C. Davis ,  Lee Earley ,  Mark Hardman ,  Adrian Land ,  Gershon Perelman

发明人： Stephen C. Davis ,  Lee Earley ,  Mark Hardman ,  Adrian Land ,  Gershon Perelman

IPC分类号： H01J49/40

CPC分类号： H01J49/40

摘要： An apparatus that comprises material which have different thermal expansion coefficients, combined in such a way that the length of the drift region is variant, and self adjusting with temperature. The adjustment is such as to compensate for the length changes resulting from thermal expansion or contraction in other ion optical elements, such that ions of substantially equivalent mass to charge ratios maintain a constant flight time though the system. This allows for use of standard construction methods for the ion optical elements.

摘要翻译： 一种包括具有不同热膨胀系数的材料的装置，其组合使得漂移区域的长度是不同的，并且随着温度自调节。 该调整是为了补偿由其它离子光学元件的热膨胀或收缩导致的长度变化，使得基本相当的质荷比的离子通过系统保持恒定的飞行时间。 这允许使用用于离子光学元件的标准施工方法。