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    Use of fatty acid esters as bioadhesive substances
    1.
    发明授权
    Use of fatty acid esters as bioadhesive substances 失效
    使用脂肪酸酯作为生物粘附物质

    公开(公告)号：US5955502A

    公开(公告)日：1999-09-21

    申请号：US829496

    申请日：1997-03-27

    申请人： Jens Hansen ,  Lise Sylvest Nielsen ,  Tomas Norling

    发明人： Jens Hansen ,  Lise Sylvest Nielsen ,  Tomas Norling

    IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K9/50 ,  A61K47/14 ,  B82B1/00 ,  A61K38/00 ,  A61K39/395

    CPC分类号： A61K9/0014 ,  A61K47/14 ,  A61K9/1274 ,  A61K9/5015 ,  A61K9/5078

    摘要： Use of fatty acid esters as bioadhesive substances. The fatty acid esters have molecular weights below about 1000 dalton and the fatty acid component of the fatty acid ester is a saturated or unsaturated fatty acid having a total number of carbon atoms of from C.sub.8 to C.sub.22. Particularly suitable fatty acid esters for use according to the invention are fatty acid esters which are selected from the group consisting of fatty acid esters of polyhydric alcohols, fatty acid esters of hydroxycarboxylic acids, fatty acid esters of monosaccharides, fatty acid esters of glycerylphosphate derivatives, fatty acid esters of glycerylsulfate derivative, and mixtures thereof. Excellent bioadhesive properties have been observed for fatty acid esters are glyceryl monooleate, glyceryl monolinoleate or glyceryl monolinolenate.Methods are described for administering an active or protective substance to undamaged or damaged skin or mucosa of an animal such as a human by combining the active or protective substance with a bioadhesive fatty acid ester. The mucosa may be the oral, aural, nasal, lung, gastrointestinal, vaginal, or rectal mucosa. The administration may also be to body cavities such as the oral cavity, e.g. via buccal administration.

    摘要翻译： 使用脂肪酸酯作为生物粘附物质。 脂肪酸酯的分子量低于约1000道尔顿，脂肪酸酯的脂肪酸组分是碳原子数为C8〜C22的饱和或不饱和脂肪酸。 根据本发明使用的特别合适的脂肪酸酯是选自多元醇的脂肪酸酯，羟基羧酸的脂肪酸酯，单糖的脂肪酸酯，磷酸甘油酯衍生物的脂肪酸酯， 甘油硫酸酯衍生物的脂肪酸酯及其混合物。 已经观察到对于脂肪酸酯具有优异的生物粘合性质，是单油酸甘油酯，单烯醇甘油酯或甘油单苯三酸盐。 描述了通过将活性或保护性物质与生物粘附性脂肪酸酯组合来将活性或保护性物质施用于动物如人的未损伤或损伤的皮肤或粘膜的方法。 粘膜可以是口服，听觉，鼻，肺，胃肠道，阴道或直肠粘膜。 给药也可以是体腔，例如口腔，例如。 通过口腔管理。

    Use of fatty acid esters as bioadhesive substances
    2.
    发明授权
    Use of fatty acid esters as bioadhesive substances 失效
    使用脂肪酸酯作为生物粘附物质

    公开(公告)号：US06228383B1

    公开(公告)日：2001-05-08

    申请号：US08462222

    申请日：1995-06-05

    申请人： Jens Hansen ,  Lise Sylvest Nielsen ,  Tomas Norling

    发明人： Jens Hansen ,  Lise Sylvest Nielsen ,  Tomas Norling

    IPC分类号： A61K3120

    CPC分类号： A61K9/5078 ,  A61K9/1274 ,  A61K9/5015 ,  A61K47/14

    摘要： Use of fatty acid esters as bioadhesive substances. The fatty acid esters have molecular weights below about 1000 dalton and the fatty acid component of the fatty acid ester is a saturated or unsaturated fatty acid having a total number of carbon atoms of from C8 to C22. Particularly suitable fatty acid esters for use according to the invention are fatty acid esters which are selected from the group consisting of fatty acid esters of polyhydric alcohols, fatty acid esters of hydroxycarboxylic acids, fatty acid esters of monosaccharides, fatty acid esters of glycerylphosphate derivatives, fatty acid esters of glycerylsulfate derivative, and mixtures thereof. Excellent bioadhesive properties have been observed for fatty acid esters are glyceryl monooleate, glyceryl monolinoleate or glyceryl monolinolenate. Methods are described for administering an active or protective substance to undamaged or damaged skin or mucosa of an animal such as a human by combining the active or protective substance with a bioadhesive fatty acid ester. The mucosa may be the oral, aural, nasal, lung, gastrointestinal, vaginal, or rectal mucosa. The administration may also be to body cavities such as the oral cavity, e.g. via buccal administration.

    摘要翻译： 使用脂肪酸酯作为生物粘附物质。 脂肪酸酯的分子量低于约1000道尔顿，脂肪酸酯的脂肪酸组分是碳原子数为C8〜C22的饱和或不饱和脂肪酸。 根据本发明使用的特别合适的脂肪酸酯是选自多元醇的脂肪酸酯，羟基羧酸的脂肪酸酯，单糖的脂肪酸酯，磷酸甘油酯衍生物的脂肪酸酯， 甘油硫酸酯衍生物的脂肪酸酯及其混合物。 已经观察到对于脂肪酸酯具有优异的生物粘合性质，是单油酸甘油酯，单烯醇甘油酯或甘油单苯三酸盐。 描述了通过将活性或保护性物质与生物粘附性脂肪酸酯组合来将活性或保护性物质施用于动物如人的未损伤或损伤的皮肤或粘膜的方法。 粘膜可以是口服，听觉，鼻，肺，胃肠道，阴道或直肠粘膜。 给药也可以是体腔，例如口腔，例如。 通过口腔管理。

    Method and Arrangement for the Sensitive Detection of Audio Events and Use Thereof
    4.
    发明申请
    Method and Arrangement for the Sensitive Detection of Audio Events and Use Thereof 审中-公开
    用于敏感检测音频事件及其使用的方法和布置

    公开(公告)号：US20080159569A1

    公开(公告)日：2008-07-03

    申请号：US11817704

    申请日：2006-03-03

    申请人： Jens Hansen

    发明人： Jens Hansen

    IPC分类号： H04R25/00

    CPC分类号： A61F11/045 ,  G09B21/003 ,  G09B21/009

    摘要： The invention relates to a method, to a device and to uses thereof for the sensitive detection of audio events in order to obtain sensations and feelings of the living skin. The audio event is broken down in to several spectral ranges, and from the signals which represent said range, control voltages are determined for a defined selection of predetermined transmitters which act upon and/or in the living skin. The selection and allocation of the control voltages is dependant on a signal analysis which uses signals which represent the spectral range. The invention relates both to the rendering of deaf people sensitive to music and to the transmission of signals to deaf people.

    摘要翻译： 本发明涉及一种方法，一种装置及其用于敏感检测音频事件的方法，以便获得活体皮肤的感觉和感觉。 音频事件被分解成多个光谱范围，并且从表示所述范围的信号中，对于作用于和/或在活体皮肤中的预定发射器的确定选择来确定控制电压。 控制电压的选择和分配取决于使用表示光谱范围的信号的信号分析。 本发明涉及对音乐敏感的聋人的呈现以及向聋人传送信号。

    FM receiver which detects and responds to receiving and interference states
    6.
    发明授权
    FM receiver which detects and responds to receiving and interference states 失效
    FM接收机，用于检测和响应接收和干扰状态

    公开(公告)号：US5251332A

    公开(公告)日：1993-10-05

    申请号：US603765

    申请日：1990-10-31

    申请人： Jens Hansen

    发明人： Jens Hansen

    IPC分类号： H03D20060101 ,  H03D3/00 ,  H04B1/16 ,  H04B1/18 ,  H04B1/10

    CPC分类号： H03D3/005 ,  H04B1/1669

    摘要： An FM receiver includes an IF unit followed by an LF unit, the IF unit having an IF filter arrangement. The center frequency of the IF filter arrangement, which is relatively narrowbanded with respect to the channel bandwidth, is controlled as a function of the receiving conditions. The receiver has circuitry for changing the signal transmission characteristic of the IF and/or LF unit, including a detector module with detector circuits for detecting values characteristic of receiving or interference states, with the inputs of these circuits each being connected with a circuit point of the IF or LF unit carrying the signal to be processed and with the outputs of these circuits providing signals characterizing receiving or interference states. The circuitry for changing the signal transmission characteristic also includes an evaluation circuit for processing the signals characteristic of receiving or interference states, the evaluation circuit having an input portion with at least one amplitude and/or time threshold circuit connected with the detector module and having a logic unit which is connected to the input portion and which provides processed signals characteristic of receiving and interference states as control signals for influencing individual stages of the IF or LF unit.

    摘要翻译： FM接收机包括IF单元，后跟LF单元，IF单元具有IF滤波器布置。 作为接收条件的函数，控制相对于信道带宽相对窄带化的IF滤波器装置的中心频率。 接收器具有用于改变IF和/或LF单元的信号传输特性的电路，包括具有用于检测接收或干扰状态特性​​值的检测器电路的检测器模块，其中每个电路的输入端与 IF或LF单元承载要处理的信号，并且这些电路的输出提供表征接收或干扰状态的信号。 用于改变信号传输特性的电路还包括用于处理接收或干扰状态特征信号的评估电路，评估电路具有输入部分，其具有与检测器模块连接的至少一个幅度和/或时间阈值电路，并具有 逻辑单元，其连接到输入部分，并且将处理后的信号特征为接收和干扰状态，作为影响IF或LF单元的各个级的控制信号。

    Hydrocarbon conversion process and catalyst
    7.
    发明申请
    Hydrocarbon conversion process and catalyst 有权
    烃转化过程和催化剂

    公开(公告)号：US20060175231A1

    公开(公告)日：2006-08-10

    申请号：US10562571

    申请日：2004-06-14

    申请人： Jens Hansen ,  Niels Blom ,  Birgitte Byberg ,  John Ward

    发明人： Jens Hansen ,  Niels Blom ,  Birgitte Byberg ,  John Ward

    IPC分类号： C10G11/04

    CPC分类号： C10G47/16 ,  C10G47/20

    摘要： A process for hydrocracking a hydrocarbonaceous feedstock into a middle distillate utilising a hydrocarbon conversion catalyst comprising a modified beta zeolite and a modified Y zeolite, an amorphous inorganic oxide and a hydrogenation component, wherein the said middle distillate is characterised by having a low aromatics content and/or a low pour point.

    摘要翻译： 使用包含改性β沸石和改性Y沸石，无定形无机氧化物和氢化组分的烃转化催化剂将含烃原料加氢裂解成中间馏分的方法，其中所述中间馏分的特征在于具有低芳烃含量和 /或低倾点。

    Oligomeric compounds for the modulation of Bcl-2
    8.
    发明申请
    Oligomeric compounds for the modulation of Bcl-2 失效
    用于调节Bcl-2的低聚物

    公开(公告)号：US20050203042A1

    公开(公告)日：2005-09-15

    申请号：US11021729

    申请日：2004-12-23

    申请人： Miriam Frieden ,  Jens Hansen ,  Henrik Orum ,  Majken Westergaard ,  Charlotte Thrue

    发明人： Miriam Frieden ,  Jens Hansen ,  Henrik Orum ,  Majken Westergaard ,  Charlotte Thrue

    IPC分类号： A61K48/00 ,  C07H21/02 ,  C12N15/113

    CPC分类号： C12N15/1135 ,  A61K48/00 ,  C07H21/00 ,  C12N2310/315 ,  C12N2310/3231

    摘要： The present invention provides improved oligomeric compound, in particular oligonucleotide compounds, and methods for modulating the expression of the Bcl-2 gene in humans. In particular, this invention relates to oligomeric compounds of 10-30 nucleobases in length which comprise a target binding domain that is specifically hybridizable to a region ranging from base position No. 1459 (5′) to No. 1476 (3′) of the human Bcl-2 mRNA, said target binding domain having the formula: 5′-[(DNA/RNA)0-1-(LNA/LNA*)2-7-(DNA/RNA/LNA*)4-14-(LNA/LNA*)2-7-(DNA/RNA)0-1]-3 and said target binding domain comprising at least two LNA nucleotides or LNA analogue nucleotides linked by a phosphorothioate group (—O—P(O,S)—O—). In particular the oligo is predominantly or fully thiolated. The invention also provides the use of such oligomers or conjugates or chimera for the treatment of various diseases associated with the expression of the Bcl-2 gene, such as cancer.

    摘要翻译： 本发明提供了改进的低聚化合物，特别是寡核苷酸化合物，以及调节人类Bcl-2基因表达的方法。 特别地，本发明涉及长度为10-30个核碱基的寡聚化合物，其包含与从第1459（5'）至第1476（3'）的基础位置区别特异性杂交的靶结合结构域 所述目标结合结构域具有下式：5' - [（DNA / RNA）0-1 - （LNA / LNA *）2-7 - （DNA / RNA / LNA *）4-14 - （LNA / LNA *）2-7 - （DNA / RNA）

    Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof
    9.
    发明授权
    Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof 失效
    用于药物递送的组合物，其包含尼古丁或其衍生物和淀粉微球体及其制备方法

    公开(公告)号：US5939100A

    公开(公告)日：1999-08-17

    申请号：US640873

    申请日：1996-08-26

    申请人： Sten Albrechtsen ,  Lene Orup-Jacobsen ,  Jens Hansen ,  Birgitte Mollgaard

    发明人： Sten Albrechtsen ,  Lene Orup-Jacobsen ,  Jens Hansen ,  Birgitte Mollgaard

    IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K31/465 ,  A61K47/36 ,  A61P21/00

    CPC分类号： A61K9/1652 ,  A61K31/465

    摘要： A powdery pharmaceutical composition comprising nicotine or a derivative thereof and starch microspheres. The starch microspheres are preferably degradable epichlorhydrin cross-linked starch microspheres. The average diameter of the microspheres is from around 1 .mu.m to around 200 .mu.m, preferably around 45 .mu.m. The invention also encompasses a method for manufacturing a powdery pharmaceutical composition comprising nicotine and starch microspheres. The invention further comprises a method of diminishing the desire of a subject to use tobacco which comprises the step of administering to the subject the above powdery pharmaceutical composition.

    摘要翻译： PCT No.PCT / SE94 / 00917 Sec。 371日期：1996年8月26日 102（e）日期1996年8月26日PCT 1994年10月3日PCT PCT。 WO95 / 12399 PCT出版物 日期1995年5月11日包含尼古丁或其衍生物和淀粉微球的粉末药物组合物。 淀粉微球优选是可降解的表氯醇交联淀粉微球。 微球的平均直径为约1μm至约200μm，优选为约45μm。 本发明还包括制备包含尼古丁和淀粉微球的粉末状药物组合物的方法。 本发明还包括减少受试者使用烟草的欲望的方法，其包括向受试者施用上述粉末状药物组合物的步骤。

    FM receiver which detects and responds to receiving and interference states
    10.
    发明授权
    FM receiver which detects and responds to receiving and interference states 失效
    FM接收机，用于检测和响应接收和干扰状态

    公开(公告)号：US5369470A

    公开(公告)日：1994-11-29

    申请号：US601743

    申请日：1990-10-31

    申请人： Jens Hansen

    发明人： Jens Hansen

    IPC分类号： H03D3/00 ,  H04B1/16 ,  H04B1/18

    CPC分类号： H04B1/1669 ,  H03D3/005

    摘要： An FM receiver includes an IF unit followed by an LF unit, the IF unit having an IF filter arrangement. The center frequency of the IF filter arrangement, which is relatively narrow-banded with respect to the channel bandwidth, is controlled in dependence on the receiving conditions. The receiver has circuitry for changing the signal transmission characteristic of the IF and/or LF units, including a detector module with detector circuits for detecting values characteristic of receiving or interference states, with the inputs of said circuits each being connected with a circuit point of the IF or LF unit carrying the signal to be processed, and with the outputs of these circuits providing signals characterizing receiving and interference states. The circuitry for changing the signal transmission characteristic also includes an evaluation circuit for processing the signals characteristic of receiving or interference states, the evaluation circuit having an input portion with at least one amplitude and/or time threshold circuit connected with the detector module and having a logic unit which is connected to the input portion and which provides processed signals characteristic of receiving and interference states as control signals to influence the individual stages of the IF or LF unit.

    摘要翻译： PCT No.PCT / DE89 / 00359 Sec。 371 1990年10月31日第 102（e）1990年10月31日PCT PCT 1989年5月30日PCT公布。 出版物WO89 / 12355 日期为1989年12月14日。一个FM接收机包括一个IF单元，随后是LF单元，IF单元具有IF滤波器布置。 依赖于接收条件来控制相对于信道带宽相对窄带化的IF滤波器装置的中心频率。 接收器具有用于改变IF和/或LF单元的信号传输特性的电路，包括具有用于检测接收或干扰状态特性​​的检测器电路的检测器模块，其中所述电路的输入端与 IF或LF单元承载要处理的信号，并且这些电路的输出提供表征接收和干扰状态的信号。 用于改变信号传输特性的电路还包括用于处理接收或干扰状态特征信号的评估电路，评估电路具有输入部分，其具有与检测器模块连接的至少一个幅度和/或时间阈值电路，并具有 逻辑单元，其连接到输入部分，并且将处理后的信号特征为接收和干扰状态作为控制信号，以影响IF或LF单元的各个级。